EA201490754A1 - Производные карбамата/мочевины, содержащие пиперидиновые и пиперазиновые кольца, в качестве ингибиторов н3 рецептора - Google Patents
Производные карбамата/мочевины, содержащие пиперидиновые и пиперазиновые кольца, в качестве ингибиторов н3 рецептораInfo
- Publication number
- EA201490754A1 EA201490754A1 EA201490754A EA201490754A EA201490754A1 EA 201490754 A1 EA201490754 A1 EA 201490754A1 EA 201490754 A EA201490754 A EA 201490754A EA 201490754 A EA201490754 A EA 201490754A EA 201490754 A1 EA201490754 A1 EA 201490754A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbamate
- urine
- derivatives
- receptor inhibitors
- containing piperidine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Изобретение относится к соединению формулы (I) или его соли, где заместители имеют значения, определенные в описании; к его получению и к лекарственным средствам, включающим такое соединение, для лечения заболеваний, связанных с ингибированием Н3 рецепторов.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011080529 | 2011-10-08 | ||
CN2012081326 | 2012-09-13 | ||
PCT/IB2012/055424 WO2013050987A1 (en) | 2011-10-08 | 2012-10-08 | Carbamate/ urea derivatives containing piperidin and piperazin rings as h3 receptor inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201490754A1 true EA201490754A1 (ru) | 2014-07-30 |
Family
ID=47278913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490754A EA201490754A1 (ru) | 2011-10-08 | 2012-10-08 | Производные карбамата/мочевины, содержащие пиперидиновые и пиперазиновые кольца, в качестве ингибиторов н3 рецептора |
Country Status (15)
Country | Link |
---|---|
US (1) | US9216182B2 (ru) |
EP (1) | EP2763978B1 (ru) |
JP (1) | JP6046149B2 (ru) |
KR (1) | KR20140072076A (ru) |
CN (1) | CN103917534B (ru) |
AR (1) | AR088256A1 (ru) |
AU (1) | AU2012320038A1 (ru) |
BR (1) | BR112014007578A2 (ru) |
CA (1) | CA2851405A1 (ru) |
EA (1) | EA201490754A1 (ru) |
ES (1) | ES2624421T3 (ru) |
IN (1) | IN2014DN01629A (ru) |
MX (1) | MX2014004254A (ru) |
TW (1) | TW201321353A (ru) |
WO (1) | WO2013050987A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9034874B2 (en) * | 2012-07-20 | 2015-05-19 | Novartis Ag | Carbamate/urea derivatives |
JP6783663B2 (ja) | 2014-01-06 | 2020-11-11 | ライゼン・ファーマシューティカルズ・エスアー | 新規グルタミナーゼ阻害剤 |
EP3391886A1 (en) | 2017-04-19 | 2018-10-24 | Novartis AG | The use of a h3r inverse agonist for the treatment of shift work disorder |
US20190381056A1 (en) | 2018-06-17 | 2019-12-19 | Axsome Therapeutics, Inc. | Compositions for delivery of reboxetine |
US20200147093A1 (en) | 2018-10-15 | 2020-05-14 | Axsome Therapeutics, Inc. | Use of esreboxetine to treat nervous system disorders such as fibromyalgia |
US11020402B2 (en) | 2018-10-15 | 2021-06-01 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
CN109666020A (zh) * | 2018-12-20 | 2019-04-23 | 苏州麦迪耐斯医药科技有限公司 | 一种新型化合物及其制备方法和应用 |
CN111057045A (zh) * | 2019-12-18 | 2020-04-24 | 安徽红杉生物医药科技有限公司 | Hcv ns3/4a蛋白酶抑制剂中间体及其合成方法、应用 |
EP4251148A1 (en) | 2020-11-27 | 2023-10-04 | Richter Gedeon Nyrt. | Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4513135A (en) * | 1982-03-05 | 1985-04-23 | Eli Lilly And Company | Diaryl-pyrazine derivatives affecting GABA binding |
FR2567518B1 (fr) * | 1984-07-11 | 1987-11-13 | Sanofi Sa | Nouveaux composes a noyau heterocyclique azote, leur preparation et les medicaments qui en contiennent |
US5124457A (en) | 1986-05-21 | 1992-06-23 | Abbott Laboratories | Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies |
TW301607B (ru) * | 1993-03-09 | 1997-04-01 | Takeda Pharm Industry Co Ltd | |
JPH06316522A (ja) * | 1993-03-09 | 1994-11-15 | Takeda Chem Ind Ltd | 細胞接着阻害剤 |
JP4522651B2 (ja) | 2001-03-13 | 2010-08-11 | シェーリング コーポレイション | 新規非イミダゾール化合物 |
JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
DK1615909T3 (da) | 2003-04-23 | 2008-11-17 | Glaxo Group Ltd | Piperazin-derivater og deres anvendelse til behandling af neurologiske og psykiatriske sygdomme |
SE0401971D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidne derivatives |
EP1909797A4 (en) * | 2005-08-02 | 2013-02-27 | Neurogen Corp | DIPIPERAZINYL KETONE AND RELATED ANALOG |
WO2007052124A1 (en) | 2005-11-04 | 2007-05-10 | Pfizer Limited | Tetrahydronaphthyridine derivative |
EP1970373A1 (en) * | 2005-12-02 | 2008-09-17 | Mitsubishi Tanabe Pharma Corporation | Alicyclic heterocyclic compound |
WO2011090062A1 (ja) | 2010-01-22 | 2011-07-28 | 大鵬薬品工業株式会社 | Pgds阻害作用を有するピペラジン化合物 |
US9034874B2 (en) | 2012-07-20 | 2015-05-19 | Novartis Ag | Carbamate/urea derivatives |
-
2012
- 2012-10-05 AR ARP120103727A patent/AR088256A1/es not_active Application Discontinuation
- 2012-10-05 TW TW101137030A patent/TW201321353A/zh unknown
- 2012-10-08 CN CN201280049386.4A patent/CN103917534B/zh active Active
- 2012-10-08 ES ES12795066.5T patent/ES2624421T3/es active Active
- 2012-10-08 EP EP12795066.5A patent/EP2763978B1/en active Active
- 2012-10-08 AU AU2012320038A patent/AU2012320038A1/en not_active Abandoned
- 2012-10-08 IN IN1629DEN2014 patent/IN2014DN01629A/en unknown
- 2012-10-08 US US14/350,159 patent/US9216182B2/en active Active
- 2012-10-08 JP JP2014534037A patent/JP6046149B2/ja active Active
- 2012-10-08 MX MX2014004254A patent/MX2014004254A/es not_active Application Discontinuation
- 2012-10-08 WO PCT/IB2012/055424 patent/WO2013050987A1/en active Application Filing
- 2012-10-08 BR BR112014007578A patent/BR112014007578A2/pt not_active Application Discontinuation
- 2012-10-08 KR KR1020147008869A patent/KR20140072076A/ko not_active Application Discontinuation
- 2012-10-08 EA EA201490754A patent/EA201490754A1/ru unknown
- 2012-10-08 CA CA2851405A patent/CA2851405A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2013050987A9 (en) | 2013-07-25 |
US20140235609A1 (en) | 2014-08-21 |
JP2014530807A (ja) | 2014-11-20 |
MX2014004254A (es) | 2014-10-17 |
WO2013050987A1 (en) | 2013-04-11 |
AU2012320038A1 (en) | 2014-04-24 |
ES2624421T3 (es) | 2017-07-14 |
AR088256A1 (es) | 2014-05-21 |
US9216182B2 (en) | 2015-12-22 |
JP6046149B2 (ja) | 2016-12-14 |
CA2851405A1 (en) | 2013-04-11 |
KR20140072076A (ko) | 2014-06-12 |
IN2014DN01629A (ru) | 2015-05-15 |
EP2763978B1 (en) | 2017-02-01 |
BR112014007578A2 (pt) | 2017-04-11 |
EP2763978A1 (en) | 2014-08-13 |
TW201321353A (zh) | 2013-06-01 |
CN103917534A (zh) | 2014-07-09 |
CN103917534B (zh) | 2016-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201490754A1 (ru) | Производные карбамата/мочевины, содержащие пиперидиновые и пиперазиновые кольца, в качестве ингибиторов н3 рецептора | |
EA201290632A1 (ru) | Производные бетулина | |
CY1117122T1 (el) | Παραγωγα πυραζολοσπειροκετονης για χρηση ως αναστολεις ακετyλ-coa καρβοξυλασης | |
TR201904340T4 (tr) | Yeni bileşikler. | |
EA201101026A1 (ru) | Ингибиторы бета-секретазы | |
CY1118093T1 (el) | Φαρμακοτεχνικες μορφες που περιλαμβανουν παραγωγα 1-(bhta-d-γλυκοπυρανοζυλ)-2-θειενυλμεθυλβενζολιου ως αναστολεις sglt | |
EA201692418A1 (ru) | Замещенные индазольные соединения в качестве irak4 ингибиторов | |
EA201690019A1 (ru) | Производное аминотриазина и содержащая его фармацевтическая композиция | |
EA201190179A1 (ru) | Способы и промежуточные химические соединения для получения фармацевтических средств | |
EA201390969A1 (ru) | Модуляторы глюкагонового рецептора | |
EA201590224A1 (ru) | Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
EA201391029A1 (ru) | Производные оксазина и их применение при лечении неврологических нарушений | |
EA201400412A1 (ru) | ЗАМЕЩЕННЫЕ БЕНЗИЛИНДАЗОЛЫ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Bub1 КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ | |
EA201390908A1 (ru) | Производные бицикло[3.2.1]октиламида и их применение | |
EA201201378A1 (ru) | Определенные аминопиримидины, композиции на их основе и способы их использования | |
EA201200176A1 (ru) | Производные оксазина и их применение для лечения неврологических нарушений | |
EA201201377A1 (ru) | Определенные аминопиридазины, композиции на их основе и способы их использования | |
EA201300250A1 (ru) | Оксадиазольные ингибиторы продуцирования лейкотриена | |
EA201691119A1 (ru) | Производные мочевины или их фармакологически приемлемые соли | |
EA201290416A1 (ru) | Новые спиропиперидиновые соединения | |
EA201790599A1 (ru) | Соединения и композиции в качестве ингибиторов киназ | |
EA201492287A1 (ru) | Дейтерированные производные руксолитиниба | |
EA201590319A1 (ru) | Новые бициклические пиридиноны | |
EA201492023A1 (ru) | Регуляторы пути комплемента и их применение | |
EA201190293A1 (ru) | Пролекарства триптолида |