PE20141204A1 - Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa - Google Patents

Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa

Info

Publication number
PE20141204A1
PE20141204A1 PE2013002531A PE2013002531A PE20141204A1 PE 20141204 A1 PE20141204 A1 PE 20141204A1 PE 2013002531 A PE2013002531 A PE 2013002531A PE 2013002531 A PE2013002531 A PE 2013002531A PE 20141204 A1 PE20141204 A1 PE 20141204A1
Authority
PE
Peru
Prior art keywords
oxo
diacilglicerol
aciltransferase
inhibitors
novel compounds
Prior art date
Application number
PE2013002531A
Other languages
English (en)
Inventor
Donghui Qin
Mui Cheung
Hemant Joshi
Raghuram Tangirala
Sridhar Reddy Bethi
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of PE20141204A1 publication Critical patent/PE20141204A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS INHIBIDORES DE DIACILGLICEROL ACILTRANSFERASA DE FORMULA (I) EN DONDE R1 ES UN SISTEMA DE ANILLO BICICLICO QUE CONSTIENE 9 A 11 MIEMBROS DEL ANILLO INCLUYENDO 1 A 4 HETEROATOMOS, ENTRE OTROS; R2 Y R3 ES INDEPENDIENTEMENTE H, ALQUILO C1-C6, HALO, HIDROXILO, ENTRE OTROS; m ES 0-2. SON COMPUESTOS PREFERIDOS EL ACIDO 2-(6-{4-AMINO-5-OXO-5H,6H,7H,8H-PIRIMIDO[5,4-F][1,4]OXAZEPIN-6-IL}-1-OXO-1,2,3,4-TETRAHIDROISOQUINOLIN-2-IL)ACETICO, 2-(6-{4-AMINO-5-OXO-5H,6H,7H,8H-PIRIMIDO[5,4-F][1,4]OXAZEPIN-6-IL}-2-OXO-1,2,3,4- TETRAHIDROISOQUINOLIN-1-IL)ACETATO DE ETILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO DE TRASTORNOS RELACIONADOS CON LA OBESIDAD
PE2013002531A 2011-05-20 2012-05-18 Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa PE20141204A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1452DE2011 2011-05-20
US201161503728P 2011-07-01 2011-07-01

Publications (1)

Publication Number Publication Date
PE20141204A1 true PE20141204A1 (es) 2014-10-05

Family

ID=47217645

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013002531A PE20141204A1 (es) 2011-05-20 2012-05-18 Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa

Country Status (34)

Country Link
US (4) US8859536B2 (es)
EP (1) EP2710013B1 (es)
JP (1) JP5844456B2 (es)
KR (1) KR101919080B1 (es)
CN (1) CN103703009B (es)
AU (1) AU2012259044B2 (es)
BR (1) BR112013029935B1 (es)
CA (1) CA2836669C (es)
CO (1) CO6811855A2 (es)
CR (1) CR20130602A (es)
CY (1) CY1118188T1 (es)
DK (1) DK2710013T3 (es)
DO (1) DOP2013000272A (es)
EA (1) EA023030B1 (es)
ES (1) ES2588748T3 (es)
HK (1) HK1194738A1 (es)
HR (1) HRP20161089T1 (es)
HU (1) HUE028870T2 (es)
IL (1) IL229488A (es)
LT (1) LT2710013T (es)
MA (1) MA35185B1 (es)
ME (1) ME02479B (es)
MX (1) MX346494B (es)
MY (1) MY184553A (es)
PE (1) PE20141204A1 (es)
PL (1) PL2710013T3 (es)
PT (1) PT2710013T (es)
RS (1) RS55006B1 (es)
SG (1) SG195044A1 (es)
SI (1) SI2710013T1 (es)
SM (1) SMT201600328B (es)
UA (1) UA111360C2 (es)
WO (1) WO2012162129A1 (es)
ZA (1) ZA201308664B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA023030B1 (ru) 2011-05-20 2016-04-29 Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед Новые соединения в качестве ингибиторов диацилглицеролацилтрансферазы
UA115079C2 (uk) 2012-11-23 2017-09-11 Глаксосмітклайн Ллс Сполуки як інгібітори діацилгліцеринацилтрансферази
WO2014081996A1 (en) * 2012-11-23 2014-05-30 Glaxosmithkline Llc Novel compounds as diacylglycerol acyltransferase inhibitors
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
CN103524431B (zh) * 2013-09-24 2016-01-13 西安交通大学 3-苄基-4-喹唑啉酮类化合物及其合成方法和应用
WO2015049668A1 (en) 2013-10-03 2015-04-09 Glaxosmithkline Intellectual Property (No.2) Limited Novel compound as a diacylglycerol acyltransferase inhibitor
WO2015049667A1 (en) 2013-10-03 2015-04-09 Glaxosmithkline Intellectual Property (No.2) Limited Novel compound as a diacylglycerol acyltransferase inhibitor
CN103880757B (zh) * 2014-04-15 2016-02-24 上海毕得医药科技有限公司 一种5-羟基嘧啶-2-羧酸的合成方法
WO2016181409A1 (en) 2015-05-11 2016-11-17 Cadila Healthcare Limited Saroglitazar magnesium for the treatment of chylomicronemia syndrome -
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
CN105732461A (zh) * 2016-02-03 2016-07-06 常州工程职业技术学院 5-甲氧基-6-卤代吲哚的制备方法
CN106083707B (zh) * 2016-06-01 2018-10-26 温州大学 一种非对称杂芳基硫醚的合成方法
CN107619932B (zh) * 2016-07-15 2020-08-07 中国科学院上海有机化学研究所 一种萃取组合物、萃取体系及其应用
CN107619928B (zh) * 2016-07-15 2020-08-07 中国科学院上海有机化学研究所 一种萃取组合物、萃取体系及其应用
RU2706655C1 (ru) * 2019-01-28 2019-11-19 Акционерное общество "Гознак" (АО "Гознак") Полимерсодержащее композиционное защищенное изделие

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090036425A1 (en) * 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
EP2373163B1 (en) * 2008-12-19 2015-06-10 Genentech, Inc. Heterocyclic compounds and methods of use
WO2010086820A1 (en) 2009-02-02 2010-08-05 Pfizer Inc. 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof
CA2755253A1 (en) * 2009-03-18 2010-09-23 Schering Corporation Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
SG175287A1 (en) * 2009-04-24 2011-11-28 Hoffmann La Roche Inhibitors of bruton's tyrosine kinase
EA023030B1 (ru) 2011-05-20 2016-04-29 Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед Новые соединения в качестве ингибиторов диацилглицеролацилтрансферазы
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors

Also Published As

Publication number Publication date
CY1118188T1 (el) 2017-06-28
EA023030B1 (ru) 2016-04-29
DOP2013000272A (es) 2014-05-15
HRP20161089T1 (hr) 2016-10-21
MX346494B (es) 2017-03-21
ME02479B (me) 2017-02-20
ZA201308664B (en) 2015-02-25
US20140378434A1 (en) 2014-12-25
HUE028870T2 (en) 2017-01-30
LT2710013T (lt) 2016-09-12
US9040517B2 (en) 2015-05-26
SI2710013T1 (sl) 2016-10-28
WO2012162129A1 (en) 2012-11-29
BR112013029935B1 (pt) 2020-12-15
CN103703009B (zh) 2016-08-17
CO6811855A2 (es) 2013-12-16
JP2014517839A (ja) 2014-07-24
CR20130602A (es) 2014-08-13
US20140080809A1 (en) 2014-03-20
EP2710013A4 (en) 2014-11-05
US20160200736A1 (en) 2016-07-14
AU2012259044A1 (en) 2013-12-12
MA35185B1 (fr) 2014-06-02
PT2710013T (pt) 2016-09-28
NZ617991A (en) 2015-06-26
CA2836669C (en) 2019-03-19
JP5844456B2 (ja) 2016-01-20
EA201391737A1 (ru) 2014-04-30
IL229488A (en) 2016-04-21
KR101919080B1 (ko) 2018-11-16
IL229488A0 (en) 2014-01-30
CA2836669A1 (en) 2012-11-29
AU2012259044B2 (en) 2015-09-17
US9540400B2 (en) 2017-01-10
DK2710013T3 (en) 2016-09-26
ES2588748T3 (es) 2016-11-04
US20150225425A1 (en) 2015-08-13
BR112013029935A2 (pt) 2016-09-20
UA111360C2 (uk) 2016-04-25
RS55006B1 (sr) 2016-11-30
MY184553A (en) 2021-04-02
EP2710013B1 (en) 2016-06-29
CN103703009A (zh) 2014-04-02
KR20140045415A (ko) 2014-04-16
US8859536B2 (en) 2014-10-14
MX2013013566A (es) 2014-01-08
SG195044A1 (en) 2013-12-30
SMT201600328B (it) 2016-11-10
US9273069B2 (en) 2016-03-01
EP2710013A1 (en) 2014-03-26
PL2710013T3 (pl) 2017-08-31
HK1194738A1 (zh) 2014-10-24

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