MX346494B - Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa. - Google Patents

Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa.

Info

Publication number
MX346494B
MX346494B MX2013013566A MX2013013566A MX346494B MX 346494 B MX346494 B MX 346494B MX 2013013566 A MX2013013566 A MX 2013013566A MX 2013013566 A MX2013013566 A MX 2013013566A MX 346494 B MX346494 B MX 346494B
Authority
MX
Mexico
Prior art keywords
dgat
novel compounds
diacylglycerol acyltransferase
obesity
acyltransferase inhibitors
Prior art date
Application number
MX2013013566A
Other languages
English (en)
Other versions
MX2013013566A (es
Inventor
Mui Cheung
Donghui Qin
Sridhar Reddy Bethi
Hemant Joshi
Raghuram Tangirala
Original Assignee
Glaxosmithkline Intellectual Property (No 2) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intellectual Property (No 2) Ltd filed Critical Glaxosmithkline Intellectual Property (No 2) Ltd
Publication of MX2013013566A publication Critical patent/MX2013013566A/es
Publication of MX346494B publication Critical patent/MX346494B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta invención se refiere a compuestos novedosos que son inhibidores de la acil coenzimaA: diacilglicerol aciltransferasa 1 (DGAT-1), a composiciones farmacéuticas que los contienen, a procedimientos para su preparación, y a su uso en terapia para la prevención o tratamiento de enfermedades relacionadas a la disfunción de DGAT-1 o donde la modulación de la actividad de DGAT-1 puede tener un beneficio terapéutico incluyendo pero no limitado a obesidad, trastornos relacionados con la obesidad, hipertrigliceridemia, hiperlipoproteinemia, cilomicronemia, dislipidemia, esteatohepatitis no alcohólica, diabetes, resistancia a insulina, síndrome metabólico, virus de la infección de hepatitis C y acné u otros trastornos de la piel.
MX2013013566A 2011-05-20 2012-05-18 Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa. MX346494B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1452DE2011 2011-05-20
US201161503728P 2011-07-01 2011-07-01
PCT/US2012/038523 WO2012162129A1 (en) 2011-05-20 2012-05-18 Novel compounds as diacylglycerol acyltransferase inhibitors

Publications (2)

Publication Number Publication Date
MX2013013566A MX2013013566A (es) 2014-01-08
MX346494B true MX346494B (es) 2017-03-21

Family

ID=47217645

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013566A MX346494B (es) 2011-05-20 2012-05-18 Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa.

Country Status (34)

Country Link
US (4) US8859536B2 (es)
EP (1) EP2710013B1 (es)
JP (1) JP5844456B2 (es)
KR (1) KR101919080B1 (es)
CN (1) CN103703009B (es)
AU (1) AU2012259044B2 (es)
BR (1) BR112013029935B1 (es)
CA (1) CA2836669C (es)
CO (1) CO6811855A2 (es)
CR (1) CR20130602A (es)
CY (1) CY1118188T1 (es)
DK (1) DK2710013T3 (es)
DO (1) DOP2013000272A (es)
EA (1) EA023030B1 (es)
ES (1) ES2588748T3 (es)
HK (1) HK1194738A1 (es)
HR (1) HRP20161089T1 (es)
HU (1) HUE028870T2 (es)
IL (1) IL229488A (es)
LT (1) LT2710013T (es)
MA (1) MA35185B1 (es)
ME (1) ME02479B (es)
MX (1) MX346494B (es)
MY (1) MY184553A (es)
PE (1) PE20141204A1 (es)
PL (1) PL2710013T3 (es)
PT (1) PT2710013T (es)
RS (1) RS55006B1 (es)
SG (1) SG195044A1 (es)
SI (1) SI2710013T1 (es)
SM (1) SMT201600328B (es)
UA (1) UA111360C2 (es)
WO (1) WO2012162129A1 (es)
ZA (1) ZA201308664B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA023030B1 (ru) 2011-05-20 2016-04-29 Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед Новые соединения в качестве ингибиторов диацилглицеролацилтрансферазы
UA115079C2 (uk) 2012-11-23 2017-09-11 Глаксосмітклайн Ллс Сполуки як інгібітори діацилгліцеринацилтрансферази
WO2014081996A1 (en) * 2012-11-23 2014-05-30 Glaxosmithkline Llc Novel compounds as diacylglycerol acyltransferase inhibitors
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
CN103524431B (zh) * 2013-09-24 2016-01-13 西安交通大学 3-苄基-4-喹唑啉酮类化合物及其合成方法和应用
WO2015049668A1 (en) 2013-10-03 2015-04-09 Glaxosmithkline Intellectual Property (No.2) Limited Novel compound as a diacylglycerol acyltransferase inhibitor
WO2015049667A1 (en) 2013-10-03 2015-04-09 Glaxosmithkline Intellectual Property (No.2) Limited Novel compound as a diacylglycerol acyltransferase inhibitor
CN103880757B (zh) * 2014-04-15 2016-02-24 上海毕得医药科技有限公司 一种5-羟基嘧啶-2-羧酸的合成方法
WO2016181409A1 (en) 2015-05-11 2016-11-17 Cadila Healthcare Limited Saroglitazar magnesium for the treatment of chylomicronemia syndrome -
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
CN105732461A (zh) * 2016-02-03 2016-07-06 常州工程职业技术学院 5-甲氧基-6-卤代吲哚的制备方法
CN106083707B (zh) * 2016-06-01 2018-10-26 温州大学 一种非对称杂芳基硫醚的合成方法
CN107619932B (zh) * 2016-07-15 2020-08-07 中国科学院上海有机化学研究所 一种萃取组合物、萃取体系及其应用
CN107619928B (zh) * 2016-07-15 2020-08-07 中国科学院上海有机化学研究所 一种萃取组合物、萃取体系及其应用
RU2706655C1 (ru) * 2019-01-28 2019-11-19 Акционерное общество "Гознак" (АО "Гознак") Полимерсодержащее композиционное защищенное изделие

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090036425A1 (en) * 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
EP2373163B1 (en) * 2008-12-19 2015-06-10 Genentech, Inc. Heterocyclic compounds and methods of use
WO2010086820A1 (en) 2009-02-02 2010-08-05 Pfizer Inc. 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof
CA2755253A1 (en) * 2009-03-18 2010-09-23 Schering Corporation Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
SG175287A1 (en) * 2009-04-24 2011-11-28 Hoffmann La Roche Inhibitors of bruton's tyrosine kinase
EA023030B1 (ru) 2011-05-20 2016-04-29 Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед Новые соединения в качестве ингибиторов диацилглицеролацилтрансферазы
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors

Also Published As

Publication number Publication date
CY1118188T1 (el) 2017-06-28
EA023030B1 (ru) 2016-04-29
DOP2013000272A (es) 2014-05-15
HRP20161089T1 (hr) 2016-10-21
ME02479B (me) 2017-02-20
ZA201308664B (en) 2015-02-25
US20140378434A1 (en) 2014-12-25
HUE028870T2 (en) 2017-01-30
LT2710013T (lt) 2016-09-12
US9040517B2 (en) 2015-05-26
SI2710013T1 (sl) 2016-10-28
WO2012162129A1 (en) 2012-11-29
BR112013029935B1 (pt) 2020-12-15
CN103703009B (zh) 2016-08-17
CO6811855A2 (es) 2013-12-16
JP2014517839A (ja) 2014-07-24
CR20130602A (es) 2014-08-13
US20140080809A1 (en) 2014-03-20
EP2710013A4 (en) 2014-11-05
US20160200736A1 (en) 2016-07-14
AU2012259044A1 (en) 2013-12-12
MA35185B1 (fr) 2014-06-02
PT2710013T (pt) 2016-09-28
NZ617991A (en) 2015-06-26
CA2836669C (en) 2019-03-19
JP5844456B2 (ja) 2016-01-20
EA201391737A1 (ru) 2014-04-30
IL229488A (en) 2016-04-21
KR101919080B1 (ko) 2018-11-16
IL229488A0 (en) 2014-01-30
CA2836669A1 (en) 2012-11-29
AU2012259044B2 (en) 2015-09-17
US9540400B2 (en) 2017-01-10
DK2710013T3 (en) 2016-09-26
ES2588748T3 (es) 2016-11-04
US20150225425A1 (en) 2015-08-13
BR112013029935A2 (pt) 2016-09-20
UA111360C2 (uk) 2016-04-25
RS55006B1 (sr) 2016-11-30
MY184553A (en) 2021-04-02
EP2710013B1 (en) 2016-06-29
CN103703009A (zh) 2014-04-02
KR20140045415A (ko) 2014-04-16
US8859536B2 (en) 2014-10-14
MX2013013566A (es) 2014-01-08
SG195044A1 (en) 2013-12-30
PE20141204A1 (es) 2014-10-05
SMT201600328B (it) 2016-11-10
US9273069B2 (en) 2016-03-01
EP2710013A1 (en) 2014-03-26
PL2710013T3 (pl) 2017-08-31
HK1194738A1 (zh) 2014-10-24

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