MX2015005733A - Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad. - Google Patents

Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad.

Info

Publication number
MX2015005733A
MX2015005733A MX2015005733A MX2015005733A MX2015005733A MX 2015005733 A MX2015005733 A MX 2015005733A MX 2015005733 A MX2015005733 A MX 2015005733A MX 2015005733 A MX2015005733 A MX 2015005733A MX 2015005733 A MX2015005733 A MX 2015005733A
Authority
MX
Mexico
Prior art keywords
obesity
tricyclic compounds
treatment
control
compounds
Prior art date
Application number
MX2015005733A
Other languages
English (en)
Inventor
Robert Zahler
Hazel Joan Dyke
Thomas David Pallin
Susan Mary Cramp
Original Assignee
Zafgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zafgen Inc filed Critical Zafgen Inc
Publication of MX2015005733A publication Critical patent/MX2015005733A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La invención proporciona compuestos tricíclicos y su uso en el tratamiento de trastornos médicos, tal como la obesidad; se proporcionan las composiciones farmacéuticas y los métodos para hacer varios compuestos tricíclicos; los compuestos se contemplan para tener actividad contra metionil aminopeptidasa 2.
MX2015005733A 2012-11-05 2013-11-05 Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad. MX2015005733A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261722449P 2012-11-05 2012-11-05
PCT/US2013/068492 WO2014071369A1 (en) 2012-11-05 2013-11-05 Tricyclic compounds for use in the treatment and/or control of obesity

Publications (1)

Publication Number Publication Date
MX2015005733A true MX2015005733A (es) 2016-02-10

Family

ID=49585658

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005733A MX2015005733A (es) 2012-11-05 2013-11-05 Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad.

Country Status (10)

Country Link
US (1) US9868717B2 (es)
EP (1) EP2925737B1 (es)
JP (1) JP2015536983A (es)
KR (1) KR20150080614A (es)
CN (1) CN104918928A (es)
AU (1) AU2013337288A1 (es)
BR (1) BR112015010223A2 (es)
CA (1) CA2890344A1 (es)
MX (1) MX2015005733A (es)
WO (1) WO2014071369A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013028534A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos
EP2804856B1 (en) 2012-01-18 2017-03-15 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
CA2890342A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds and methods of making and using same
WO2014071368A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Methods of treating liver diseases
KR20150080614A (ko) 2012-11-05 2015-07-09 자프겐 인크. 비만의 치료 및/또는 제어에서 사용하기 위한 트리시클릭 화합물

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Also Published As

Publication number Publication date
BR112015010223A2 (pt) 2017-07-11
CN104918928A (zh) 2015-09-16
JP2015536983A (ja) 2015-12-24
CA2890344A1 (en) 2014-05-08
US20160083362A1 (en) 2016-03-24
EP2925737A1 (en) 2015-10-07
US9868717B2 (en) 2018-01-16
AU2013337288A1 (en) 2015-05-21
WO2014071369A1 (en) 2014-05-08
EP2925737B1 (en) 2017-06-14
KR20150080614A (ko) 2015-07-09

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