MX362721B - Derivados de ácido n-acil amino para tratar condiciones de la piel tales como celulitis. - Google Patents

Derivados de ácido n-acil amino para tratar condiciones de la piel tales como celulitis.

Info

Publication number
MX362721B
MX362721B MX2012014751A MX2012014751A MX362721B MX 362721 B MX362721 B MX 362721B MX 2012014751 A MX2012014751 A MX 2012014751A MX 2012014751 A MX2012014751 A MX 2012014751A MX 362721 B MX362721 B MX 362721B
Authority
MX
Mexico
Prior art keywords
cellulite
skin conditions
treating skin
amino acid
acid derivatives
Prior art date
Application number
MX2012014751A
Other languages
English (en)
Other versions
MX2012014751A (es
Inventor
Zhang Lijuan
J Falla Timothy
Original Assignee
Helix Biomedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helix Biomedix Inc filed Critical Helix Biomedix Inc
Publication of MX2012014751A publication Critical patent/MX2012014751A/es
Publication of MX362721B publication Critical patent/MX362721B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Moléculas pequeñas que tienen actividad biológica y terapéutica. Particularmente, la invención se relaciona con moléculas pequeñas que tienen actividad lipolítica y anti-adipogénica. Dos ejemplos de dichas moléculas son el ácido 4-metil-2-(octanoilamino) pentanoico y la N-isopentiloctanamida. La invención además se relaciona con métodos para prevenir o tratar trastornos de la piel tales como la celulitis usando moléculas pequeñas que tienen actividad lipolítica y anti-adipogénica.
MX2012014751A 2010-07-02 2011-06-28 Derivados de ácido n-acil amino para tratar condiciones de la piel tales como celulitis. MX362721B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36117910P 2010-07-02 2010-07-02
PCT/US2011/042123 WO2012003176A1 (en) 2010-07-02 2011-06-28 N-acyl amino acid derivatives for treating skin conditions such as cellulite

Publications (2)

Publication Number Publication Date
MX2012014751A MX2012014751A (es) 2013-02-15
MX362721B true MX362721B (es) 2015-02-27

Family

ID=44326260

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014751A MX362721B (es) 2010-07-02 2011-06-28 Derivados de ácido n-acil amino para tratar condiciones de la piel tales como celulitis.

Country Status (22)

Country Link
US (1) US9511042B2 (es)
EP (1) EP2588101B1 (es)
JP (1) JP6043283B2 (es)
KR (1) KR101639196B1 (es)
CN (1) CN103079553B (es)
AR (1) AR082277A1 (es)
AU (1) AU2011271466B2 (es)
BR (1) BR112013000045A2 (es)
CA (1) CA2800301C (es)
DK (1) DK2588101T3 (es)
ES (1) ES2528012T3 (es)
HK (1) HK1179893A1 (es)
MX (1) MX362721B (es)
MY (1) MY156618A (es)
NZ (1) NZ605804A (es)
PL (1) PL2588101T3 (es)
RU (1) RU2590977C2 (es)
SG (1) SG186234A1 (es)
SI (1) SI2588101T1 (es)
TW (1) TWI539945B (es)
WO (1) WO2012003176A1 (es)
ZA (1) ZA201209603B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6473505B2 (ja) * 2014-08-28 2019-02-20 カリウェイ バイオファーマシューティカルズ カンパニー リミテッド 局所の脂肪と体重の減少に用いられる組成物およびその医薬品と使用
US10226503B2 (en) 2014-08-28 2019-03-12 Caliway Biopharmaceuticals Co., Ltd. Plant extract composition for reducing topical fat and promoting weight loss as well as applications thereof
MX2018002462A (es) 2015-08-28 2018-06-19 Caliway Biopharmaceuticals Co Ltd Una composicion farmaceutica para reducir la grasa localizada y sus usos.
US11318110B2 (en) 2015-08-28 2022-05-03 Caliway Biopharmaceuticals Co., Ltd. Pharmaceutical composition for reducing local fat and uses thereof
BR112018077141B1 (pt) * 2016-07-27 2022-02-01 Unilever Ip Holdings B.V. Composição de cuidados pessoais e usos de uma composição de cuidados da pele
WO2019071093A1 (en) * 2017-10-05 2019-04-11 North Carolina State University ALKAMIDE COMPOUNDS AND USES THEREOF

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85643A1 (fr) 1984-11-16 1986-06-04 Oreal Composition cosmetique thermo-amincissante a base d'extraits vegetaux oleosolubles
US5510531A (en) 1989-04-10 1996-04-23 Suntory Limited Proteinase inhibitor
JP2701932B2 (ja) * 1989-04-10 1998-01-21 サントリー株式会社 タンパク質分解酵素阻害剤
DK255889D0 (da) 1989-05-25 1989-05-25 Novo Nordisk As Fremgangsmaade til fremstilling af organiske forbindelser
EP0500332B1 (en) * 1991-02-19 1998-05-27 National Food Research Institute Ministry Of Agriculture, Forestry And Fisheries Novel acylamino acid compounds and a method for their production
JPH08337515A (ja) * 1995-04-11 1996-12-24 Kashima Sekiyu Kk 化粧料
FR2789085B1 (fr) * 1999-01-29 2003-06-20 Arkopharma Laboratoires Procede d'obtention d'une huile enrichie en acides gras hydroxyoctadecadienoiques (hode), ou de ses esters a partir d'un melange huileux contenant de l'acide linoleique, ou ses esters
US6492326B1 (en) 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
CN1523982A (zh) 2001-03-27 2004-08-25 ���������Ǵ�ѧ���»� 减少体脂和调节脂肪酸代谢的方法、化合物和组合物
US20050019372A1 (en) 2001-07-10 2005-01-27 Barbara E Corkey Modified-fat nutritional products useful preventing or treating obesity
ITMI20030210A1 (it) * 2003-02-07 2004-08-08 Res & Innovation Soc Coop A R L Composti endocannabinoido-simili e loro impiego
JP2005194252A (ja) * 2004-01-09 2005-07-21 Shiseido Co Ltd 脂肪蓄積抑制用組成物
WO2006029818A2 (en) 2004-09-16 2006-03-23 Dsm Ip Assets B.V. Cosmetic compositions containing an hydroxamic acid compound optionally in combination with a retinoid
JP4527655B2 (ja) * 2004-11-30 2010-08-18 ライオン株式会社 フォーマー容器入り洗浄剤組成物
JP2008105945A (ja) 2005-02-07 2008-05-08 Ajinomoto Co Inc アディポネクチンの分泌促進又は誘導作用を有するアシルアミド化合物
JP2007153845A (ja) * 2005-12-07 2007-06-21 Yamaha Motor Co Ltd 脂肪蓄積抑制剤
JP5105297B2 (ja) * 2006-05-25 2012-12-26 味の素株式会社 Ｐｐａｒ活性調節剤
DE102006060439A1 (de) * 2006-12-19 2008-06-26 Henkel Kgaa Verbesserung der Hautverträglichkeit von hyperämisierenden Wirkstoffen
US20080200704A1 (en) 2007-02-20 2008-08-21 Multi Formulations Ltd. Preparation of amino acid-fatty acid amides

Also Published As

Publication number Publication date
TWI539945B (zh) 2016-07-01
RU2590977C2 (ru) 2016-07-10
MX2012014751A (es) 2013-02-15
CA2800301C (en) 2018-03-27
AU2011271466B2 (en) 2013-08-22
DK2588101T3 (en) 2015-02-02
MY156618A (en) 2016-03-15
CA2800301A1 (en) 2012-01-05
TW201201794A (en) 2012-01-16
KR101639196B1 (ko) 2016-07-14
US20130096143A1 (en) 2013-04-18
JP6043283B2 (ja) 2016-12-14
SG186234A1 (en) 2013-01-30
ES2528012T3 (es) 2015-02-03
AR082277A1 (es) 2012-11-28
BR112013000045A2 (pt) 2016-05-10
PL2588101T3 (pl) 2015-03-31
RU2013104424A (ru) 2014-08-10
JP2013530233A (ja) 2013-07-25
KR20130029432A (ko) 2013-03-22
HK1179893A1 (en) 2013-10-11
EP2588101A1 (en) 2013-05-08
EP2588101B1 (en) 2014-10-22
WO2012003176A1 (en) 2012-01-05
AU2011271466A1 (en) 2012-12-20
US9511042B2 (en) 2016-12-06
CN103079553B (zh) 2016-01-20
ZA201209603B (en) 2013-08-28
NZ605804A (en) 2014-03-28
SI2588101T1 (sl) 2015-01-30
CN103079553A (zh) 2013-05-01

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