MX2013012661A - Compuestos de piridazina biciclicos como inhibidores pim. - Google Patents

Compuestos de piridazina biciclicos como inhibidores pim.

Info

Publication number
MX2013012661A
MX2013012661A MX2013012661A MX2013012661A MX2013012661A MX 2013012661 A MX2013012661 A MX 2013012661A MX 2013012661 A MX2013012661 A MX 2013012661A MX 2013012661 A MX2013012661 A MX 2013012661A MX 2013012661 A MX2013012661 A MX 2013012661A
Authority
MX
Mexico
Prior art keywords
pim
relates
pyridazine compounds
bicyclic
pim inhibitors
Prior art date
Application number
MX2013012661A
Other languages
English (en)
Inventor
Hui-Ling Wang
Bradley J Herberich
Claire L M Jackson
Liping H Pettus
Bin Wu
Ryan Wurz
Andrew Tasker
Derin C D Amico
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2013012661A publication Critical patent/MX2013012661A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La invención se refiere a compuestos bicíclicos de las fórmula I y I´, y sales de los mismos. En algunas modalidades, la invención se refiere a inhibidores o moduladores de la actividad de proteína cinasa Pim-1 y/o Pim-2 y/o Pim-3 o función de enzima. Todavía en modalidades adicionales, la invención se refiere a composiciones farmacéuticas que comprenden compuestos descritos en la presente, y su uso en la prevención y tratamiento de afecciones y enfermedades relacionadas con la cinasa Pim, preferiblemente cáncer.
MX2013012661A 2011-04-29 2012-04-19 Compuestos de piridazina biciclicos como inhibidores pim. MX2013012661A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161480703P 2011-04-29 2011-04-29
PCT/US2012/034272 WO2012148775A1 (en) 2011-04-29 2012-04-19 Bicyclic pyridazine compounds as pim inhibitors

Publications (1)

Publication Number Publication Date
MX2013012661A true MX2013012661A (es) 2014-03-27

Family

ID=46018118

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012661A MX2013012661A (es) 2011-04-29 2012-04-19 Compuestos de piridazina biciclicos como inhibidores pim.

Country Status (7)

Country Link
US (1) US9187486B2 (es)
EP (1) EP2702063A1 (es)
JP (1) JP2014516941A (es)
AU (1) AU2012250026A1 (es)
CA (1) CA2834166A1 (es)
MX (1) MX2013012661A (es)
WO (1) WO2012148775A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150336960A1 (en) 2012-12-19 2015-11-26 Novartis Ag Aryl-substituted fused bicyclic pyridazine compounds
CA2897200C (en) 2013-01-14 2021-07-06 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
US9200004B2 (en) 2013-01-15 2015-12-01 Incyte Holdings Corporation Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
US9796719B2 (en) * 2013-06-19 2017-10-24 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2015009888A2 (en) 2013-07-19 2015-01-22 Onyx Therapeutics, Inc. Peptide epoxyketone proteasome inhibitors in combination with pim kinase inhibitors for treatment of cancers
SG11201601259YA (en) 2013-08-23 2016-03-30 Incyte Corp Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
EP3432886B1 (en) 2016-03-25 2021-06-02 University of Maryland, Baltimore County Pim kinase inhibitors in combination with rna splicing modulators/inhibitors for treatment of cancers
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
CN112094224B (zh) * 2019-06-18 2022-08-26 浙江医药股份有限公司新昌制药厂 一种带保护基的3-取代-5-氨基哌啶的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
DE3311753A1 (de) 1983-03-31 1984-10-04 Hoechst Ag, 6230 Frankfurt Substituierte 6-aryl-1,2,4-triazolo(4,3-b)pyridazine - ihre herstellung und verwendung -
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US7268136B2 (en) * 2002-12-18 2007-09-11 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
WO2006106326A1 (en) 2005-04-06 2006-10-12 Astrazeneca Ab Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors
JP5330274B2 (ja) 2007-03-01 2013-10-30 ノバルティス アーゲー Ｐｉｍキナーゼ阻害剤およびその使用方法
US8168794B2 (en) 2008-03-03 2012-05-01 Novartis Ag Pim kinase inhibitors and methods of their use
AR070531A1 (es) 2008-03-03 2010-04-14 Novartis Ag Inhibidores de cinasa pim y metodos para su uso
CL2009001152A1 (es) 2008-05-13 2009-10-16 Array Biopharma Inc Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa.
GEP20135849B (en) 2008-09-02 2013-06-10 Novartis Ag Picolinamide derivatives as kinase inhibitors

Also Published As

Publication number Publication date
US9187486B2 (en) 2015-11-17
CA2834166A1 (en) 2012-11-01
JP2014516941A (ja) 2014-07-17
AU2012250026A1 (en) 2013-10-31
WO2012148775A1 (en) 2012-11-01
US20140221344A1 (en) 2014-08-07
EP2702063A1 (en) 2014-03-05

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