CL2009001152A1 - Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. - Google Patents
Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa.Info
- Publication number
- CL2009001152A1 CL2009001152A1 CL2009001152A CL2009001152A CL2009001152A1 CL 2009001152 A1 CL2009001152 A1 CL 2009001152A1 CL 2009001152 A CL2009001152 A CL 2009001152A CL 2009001152 A CL2009001152 A CL 2009001152A CL 2009001152 A1 CL2009001152 A1 CL 2009001152A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- pharmaceutical composition
- pyrrolo
- pyridin
- amide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
LA PRESENTE INVENCIÓN TRATA SOBRE COMPUESTOS DE FÓRMULA I COMO INHIBIDORES DE CHK1, Y UN PROCESO PARA PREPARAR DICHOS COMPUESTOS. TAMBIÉN SE REVELA UNA COMPOSICIÓN FARMACÉUTICA QUE CONTIENE DICHO COMPUESTO Y SU USO EN EL TRATAMIENTO UNA ENFERMEDAD HIPERPROLIFERATIVA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5292608P | 2008-05-13 | 2008-05-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009001152A1 true CL2009001152A1 (es) | 2009-10-16 |
Family
ID=40810786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009001152A CL2009001152A1 (es) | 2008-05-13 | 2009-05-12 | Compuestos derivados de n-(4-(cicloalquilo nitrogenado-1-il)-1h-pirrolo[2,3-b]piridin-3-il)amida, inhibidores de cinasa; proceso de preparacion; composicion farmaceutica; y su uso para el tratamiento de una enfermedad proliferativa. |
Country Status (30)
Country | Link |
---|---|
US (6) | US8178131B2 (es) |
EP (2) | EP2307409B1 (es) |
JP (2) | JP5703212B2 (es) |
KR (2) | KR101643426B1 (es) |
CN (3) | CN104926810B (es) |
AR (1) | AR071717A1 (es) |
AU (1) | AU2009246402B2 (es) |
BR (1) | BRPI0913580B8 (es) |
CA (1) | CA2724262C (es) |
CL (1) | CL2009001152A1 (es) |
CO (1) | CO6321244A2 (es) |
CR (1) | CR11803A (es) |
CY (1) | CY1116692T1 (es) |
DK (1) | DK2307409T3 (es) |
ES (1) | ES2552643T3 (es) |
HK (2) | HK1152035A1 (es) |
HR (1) | HRP20151018T1 (es) |
HU (1) | HUE026160T2 (es) |
IL (1) | IL209258A (es) |
MX (1) | MX2010012449A (es) |
NZ (1) | NZ589318A (es) |
PH (1) | PH12013501779A1 (es) |
PL (1) | PL2307409T3 (es) |
PT (1) | PT2307409E (es) |
RS (1) | RS54358B1 (es) |
RU (1) | RU2517194C2 (es) |
SI (1) | SI2307409T1 (es) |
TW (2) | TWI458727B (es) |
UA (1) | UA111933C2 (es) |
WO (1) | WO2009140320A1 (es) |
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AR071717A1 (es) * | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
NZ596125A (en) * | 2009-04-11 | 2012-08-31 | Array Biopharma Inc | Checkpoint kinase 1 inhibitors for potentiating dna damaging agents |
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TWI466885B (zh) | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
US9029359B2 (en) | 2009-09-04 | 2015-05-12 | Biogen Idec Ma, Inc. | Heteroaryl Btk inhibitors |
CA2808543C (en) | 2010-08-20 | 2016-01-26 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
ES2621857T3 (es) * | 2010-11-16 | 2017-07-05 | Array Biopharma, Inc. | Combinación de inhibidores de la cinasa 1 de punto de control e inhibidores de la cinasa WEE1 |
AU2012254082B2 (en) | 2011-02-25 | 2016-12-08 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
EP2702063A1 (en) | 2011-04-29 | 2014-03-05 | Amgen Inc. | Bicyclic pyridazine compounds as pim inhibitors |
GB201201566D0 (en) * | 2012-01-30 | 2012-03-14 | Vernalis R&D Ltd | New chemical compounds |
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WO2015027090A1 (en) * | 2013-08-22 | 2015-02-26 | Genentech, Inc. | Intermediates and processes for preparing compounds |
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EP3817820A1 (en) | 2018-07-03 | 2021-05-12 | IFM Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
CN109053526A (zh) * | 2018-08-13 | 2018-12-21 | 南通大学 | 一种(3r,4s)-4-甲基吡咯烷-3-基氨基甲酸叔丁酯盐酸盐的化学合成方法 |
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TW202043198A (zh) | 2019-01-17 | 2020-12-01 | 美商Ifm Due有限公司 | 用於治療與sting活性相關之病況的化合物及組合物 |
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AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
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2009
- 2009-05-12 AR ARP090101708A patent/AR071717A1/es active IP Right Grant
- 2009-05-12 CL CL2009001152A patent/CL2009001152A1/es unknown
- 2009-05-13 ES ES09747404.3T patent/ES2552643T3/es active Active
- 2009-05-13 KR KR1020107027941A patent/KR101643426B1/ko active IP Right Grant
- 2009-05-13 EP EP09747404.3A patent/EP2307409B1/en active Active
- 2009-05-13 CN CN201510289964.7A patent/CN104926810B/zh active Active
- 2009-05-13 EP EP15175131.0A patent/EP2990407B1/en active Active
- 2009-05-13 NZ NZ589318A patent/NZ589318A/en not_active IP Right Cessation
- 2009-05-13 KR KR1020147015705A patent/KR101657856B1/ko active IP Right Grant
- 2009-05-13 RS RS20150711A patent/RS54358B1/en unknown
- 2009-05-13 MX MX2010012449A patent/MX2010012449A/es active IP Right Grant
- 2009-05-13 TW TW098115906A patent/TWI458727B/zh active
- 2009-05-13 TW TW103133772A patent/TWI554512B/zh active
- 2009-05-13 DK DK09747404.3T patent/DK2307409T3/en active
- 2009-05-13 BR BRPI0913580A patent/BRPI0913580B8/pt not_active IP Right Cessation
- 2009-05-13 JP JP2011509628A patent/JP5703212B2/ja not_active Expired - Fee Related
- 2009-05-13 US US12/992,468 patent/US8178131B2/en active Active
- 2009-05-13 SI SI200931284T patent/SI2307409T1/sl unknown
- 2009-05-13 CN CN201910068067.1A patent/CN109942575A/zh active Pending
- 2009-05-13 CA CA2724262A patent/CA2724262C/en active Active
- 2009-05-13 PT PT97474043T patent/PT2307409E/pt unknown
- 2009-05-13 RU RU2010150786/04A patent/RU2517194C2/ru active
- 2009-05-13 HU HUE09747404A patent/HUE026160T2/en unknown
- 2009-05-13 CN CN200980127299.4A patent/CN102089307B/zh active Active
- 2009-05-13 AU AU2009246402A patent/AU2009246402B2/en not_active Ceased
- 2009-05-13 PL PL09747404T patent/PL2307409T3/pl unknown
- 2009-05-13 UA UAA201015012A patent/UA111933C2/uk unknown
- 2009-05-13 WO PCT/US2009/043691 patent/WO2009140320A1/en active Application Filing
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2010
- 2010-11-11 IL IL209258A patent/IL209258A/en active IP Right Grant
- 2010-11-19 CR CR11803A patent/CR11803A/es unknown
- 2010-11-30 CO CO10150963A patent/CO6321244A2/es active IP Right Grant
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2011
- 2011-06-14 HK HK11106054.7A patent/HK1152035A1/xx not_active IP Right Cessation
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2012
- 2012-03-20 US US13/425,186 patent/US8545897B2/en active Active
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2013
- 2013-08-23 US US13/974,895 patent/US8758830B2/en active Active
- 2013-08-28 PH PH12013501779A patent/PH12013501779A1/en unknown
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2014
- 2014-05-06 US US14/271,129 patent/US8981085B2/en active Active
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2015
- 2015-01-07 US US14/591,691 patent/US9365568B2/en active Active
- 2015-02-23 JP JP2015032474A patent/JP2015098482A/ja not_active Withdrawn
- 2015-09-16 CY CY20151100812T patent/CY1116692T1/el unknown
- 2015-09-28 HR HRP20151018TT patent/HRP20151018T1/hr unknown
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2016
- 2016-01-05 US US14/988,521 patent/US9969727B2/en active Active
- 2016-07-08 HK HK16107983.6A patent/HK1219950A1/zh unknown
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