MX2013005445A - Pirazolopiridinas y el uso de pirazolopiridinas como inhibidores de tirosina cinasa 2 (tyk2). - Google Patents
Pirazolopiridinas y el uso de pirazolopiridinas como inhibidores de tirosina cinasa 2 (tyk2).Info
- Publication number
- MX2013005445A MX2013005445A MX2013005445A MX2013005445A MX2013005445A MX 2013005445 A MX2013005445 A MX 2013005445A MX 2013005445 A MX2013005445 A MX 2013005445A MX 2013005445 A MX2013005445 A MX 2013005445A MX 2013005445 A MX2013005445 A MX 2013005445A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazolopyridines
- tyk2 inhibitors
- compound
- formula
- pharmaceutically acceptable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona compuestos de la fórmula (I), estereoisómeros o sales farmacéuticamente aceptables de los mismos, (Ver Formula) en donde A, X, R1, R2, R4 y R5 se definen en la presente, una composición farmacéutica que incluye un compuesto de la fórmula (I) y un portador, adyuvante o vehículo farmacéuticamente aceptable, y métodos para usar el compuesto o composición en terapia, como inhibidores de cinasa TYK2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41578210P | 2010-11-19 | 2010-11-19 | |
PCT/EP2011/070313 WO2012066061A1 (en) | 2010-11-19 | 2011-11-17 | Pyrazolopyridines and pyrazolopyridines and their use as tyk2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013005445A true MX2013005445A (es) | 2013-07-29 |
Family
ID=45093712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013005445A MX2013005445A (es) | 2010-11-19 | 2011-11-17 | Pirazolopiridinas y el uso de pirazolopiridinas como inhibidores de tirosina cinasa 2 (tyk2). |
Country Status (10)
Country | Link |
---|---|
US (1) | US9309240B2 (es) |
EP (1) | EP2640722B1 (es) |
JP (1) | JP2013542966A (es) |
KR (1) | KR20140009259A (es) |
CN (1) | CN103313987A (es) |
BR (1) | BR112013011520A2 (es) |
CA (1) | CA2817785A1 (es) |
MX (1) | MX2013005445A (es) |
RU (1) | RU2013126041A (es) |
WO (1) | WO2012066061A1 (es) |
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MX2011003447A (es) | 2008-09-30 | 2011-07-29 | Astrazeneca Ab | Inhibidores heterociclicos de jak quinasa. |
UA104010C2 (en) | 2008-12-18 | 2013-12-25 | Эли Лилли Энд Компани | Purine compounds |
NZ593951A (en) | 2009-02-06 | 2013-01-25 | Ortho Mcneil Janssen Pharm | Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
MX2012004020A (es) * | 2009-10-20 | 2012-05-08 | Cellzome Ltd | Analogos de heterociclilo pirazolopirimidina como inhibidores de jak. |
MX2012010265A (es) * | 2010-03-17 | 2012-10-01 | Hoffmann La Roche | Compuestos de imidazopiridina, composiciones y metodos de uso. |
CN103180322A (zh) * | 2010-04-30 | 2013-06-26 | 塞尔佐姆有限公司 | 作为jak抑制剂的吡唑化合物 |
EP2616072A1 (en) * | 2010-09-15 | 2013-07-24 | F.Hoffmann-La Roche Ag | Azabenzothiazole compounds, compositions and methods of use |
-
2011
- 2011-11-17 JP JP2013539251A patent/JP2013542966A/ja active Pending
- 2011-11-17 MX MX2013005445A patent/MX2013005445A/es not_active Application Discontinuation
- 2011-11-17 KR KR1020137015732A patent/KR20140009259A/ko not_active Application Discontinuation
- 2011-11-17 CN CN2011800652349A patent/CN103313987A/zh active Pending
- 2011-11-17 CA CA2817785A patent/CA2817785A1/en not_active Abandoned
- 2011-11-17 RU RU2013126041/04A patent/RU2013126041A/ru not_active Application Discontinuation
- 2011-11-17 WO PCT/EP2011/070313 patent/WO2012066061A1/en active Application Filing
- 2011-11-17 BR BR112013011520A patent/BR112013011520A2/pt not_active IP Right Cessation
- 2011-11-17 EP EP11790910.1A patent/EP2640722B1/en not_active Not-in-force
-
2013
- 2013-05-16 US US13/896,024 patent/US9309240B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20140009259A (ko) | 2014-01-22 |
BR112013011520A2 (pt) | 2019-09-24 |
US20130252941A1 (en) | 2013-09-26 |
RU2013126041A (ru) | 2014-12-27 |
EP2640722A1 (en) | 2013-09-25 |
WO2012066061A1 (en) | 2012-05-24 |
CN103313987A (zh) | 2013-09-18 |
US9309240B2 (en) | 2016-04-12 |
JP2013542966A (ja) | 2013-11-28 |
CA2817785A1 (en) | 2012-05-24 |
EP2640722B1 (en) | 2015-11-04 |
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