EA201000882A1 - Соединение, его применение и фармацевтическая композиция, содержащая это соединение - Google Patents

Соединение, его применение и фармацевтическая композиция, содержащая это соединение

Info

Publication number
EA201000882A1
EA201000882A1 EA201000882A EA201000882A EA201000882A1 EA 201000882 A1 EA201000882 A1 EA 201000882A1 EA 201000882 A EA201000882 A EA 201000882A EA 201000882 A EA201000882 A EA 201000882A EA 201000882 A1 EA201000882 A1 EA 201000882A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
application
pharmaceutical composition
composition containing
compounds
Prior art date
Application number
EA201000882A
Other languages
English (en)
Inventor
Петер Херольд
Роберт Мах
Винченцо Чинке
Стьепан Елаковиц
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201000882A1 publication Critical patent/EA201000882A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

В заявке описаны соединения общей формулы (I)и их соли, предпочтительно их фармацевтически приемлемые соли, в которых Rобладает значениями, указанными в описании, способ их получения и применение этих соединений в качестве лекарственных средств, в особенности в качестве ингибиторов ренина.
EA201000882A 2007-12-05 2008-12-04 Соединение, его применение и фармацевтическая композиция, содержащая это соединение EA201000882A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07122363 2007-12-05
PCT/EP2008/066747 WO2009071606A1 (en) 2007-12-05 2008-12-04 Organic compounds

Publications (1)

Publication Number Publication Date
EA201000882A1 true EA201000882A1 (ru) 2011-02-28

Family

ID=39203128

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000882A EA201000882A1 (ru) 2007-12-05 2008-12-04 Соединение, его применение и фармацевтическая композиция, содержащая это соединение

Country Status (13)

Country Link
US (1) US8003640B2 (ru)
EP (1) EP2229384A1 (ru)
JP (1) JP2011506287A (ru)
KR (1) KR20100112550A (ru)
CN (1) CN101918396A (ru)
AR (1) AR069569A1 (ru)
AU (1) AU2008333201A1 (ru)
BR (1) BRPI0820013A2 (ru)
CA (1) CA2705722A1 (ru)
EA (1) EA201000882A1 (ru)
MX (1) MX2010006218A (ru)
TW (1) TW200932241A (ru)
WO (1) WO2009071606A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090270380A1 (en) * 2005-03-31 2009-10-29 Peter Herold 3,4,5-Substituted Piperidines as Renin Inhibitors
WO2009078481A1 (ja) 2007-12-19 2009-06-25 Dainippon Sumitomo Pharma Co., Ltd. 二環性へテロ環誘導体
WO2010150840A1 (ja) 2009-06-24 2010-12-29 大日本住友製薬株式会社 Ｎ－置換－環状アミノ誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63264573A (ja) 1986-04-24 1988-11-01 Toray Ind Inc 光学活性６−置換−ピリジン−３−カルボン酸エステル化合物および液晶
DK0863875T3 (da) 1995-09-07 2003-12-01 Hoffmann La Roche Hidtil ukendte 4-(oxyalkoxyphenyl)-3-oxy-piperiner til behandling af hjerte- og nyrelidelser
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
AR045950A1 (es) 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
AR053406A1 (es) 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
US20090270380A1 (en) 2005-03-31 2009-10-29 Peter Herold 3,4,5-Substituted Piperidines as Renin Inhibitors
JP2009514809A (ja) 2005-10-18 2009-04-09 ニコックス エス エイ レニン阻害剤のニトロ誘導体
TW200804359A (en) 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
EP1911758A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenyl piperidine derivatives for use as renin inhibitors

Also Published As

Publication number Publication date
CN101918396A (zh) 2010-12-15
AU2008333201A1 (en) 2009-06-11
MX2010006218A (es) 2010-06-23
WO2009071606A1 (en) 2009-06-11
TW200932241A (en) 2009-08-01
EP2229384A1 (en) 2010-09-22
CA2705722A1 (en) 2009-06-11
AR069569A1 (es) 2010-02-03
US8003640B2 (en) 2011-08-23
KR20100112550A (ko) 2010-10-19
BRPI0820013A2 (pt) 2015-05-19
JP2011506287A (ja) 2011-03-03
US20100303926A1 (en) 2010-12-02

Similar Documents

Publication Publication Date Title
EA200970156A1 (ru) Пиридизиноновые производные
BR112012026767A2 (pt) composto, sal farmaceuticamente aceitável de um composto, composição farmacêutica, método para tratar ou previnir distúrbios, e, uso de um composto ou sal
EA201170772A1 (ru) Органические соединения
EA201101672A1 (ru) Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
EA201290183A1 (ru) Бензодиазепиновый ингибитор бромодомена
EA201001205A1 (ru) Соединения, содержащие циклобутоксигруппу
EA201100030A1 (ru) Пиразольные соединения 436
EA201001368A1 (ru) Гетероциклические производные мочевины и способы их применения-211
EA200970585A1 (ru) Бензамидные производные как агонисты ер-рецепторов
UY32156A (es) Derivados sustituidos de la n2 - [1-(5 - fluoropirimidin -2-il) etil] - n4 - (1-metil - 1h-imidazol - 4 - il)) - pirimidina - 2,4 - diaminas y sus sales farmacéuticamente aceptables, proceso de preparación, composiciones conteniéndolos y aplicaciones.
UY32062A (es) Inhibidores de beta-secretasa
MX2010001754A (es) Derivados de azepina como inhibidores de gamma secretasa.
EA201001013A1 (ru) Бис(сульфониламино)производные для применения в терапии
EA200870217A1 (ru) 4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции
MY149512A (en) Pyrazolylaminopyridine derivatives useful as kinase inhibitors
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
EA201070167A1 (ru) Замещенные производные индазола, активные как ингибиторы киназы
EA201070786A1 (ru) Бензофуропиримидиноны
EA201070588A1 (ru) Производные 1,2,3-триазола для применения в качестве ингибиторов стеароил-соа десатуразы
EA201071224A1 (ru) Ингибиторы limk2, композиции, содержащие их, и способы их применения
EA201170722A1 (ru) Лактамы в качестве ингибиторов бета-секретазы
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
EA201001747A1 (ru) Бензоксазиноновые производные, действующие в качестве агониста бета-2-адренорецептора, для лечения респираторных расстройств
WO2009105969A8 (zh) 埃坡霉素类似物、其药物组合物、用途及其制备方法
EA201001859A1 (ru) Гетероциклические производные мочевины и способы их применеия