EA201101672A1 - Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина - Google Patents

Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина

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Publication number
EA201101672A1
EA201101672A1 EA201101672A EA201101672A EA201101672A1 EA 201101672 A1 EA201101672 A1 EA 201101672A1 EA 201101672 A EA201101672 A EA 201101672A EA 201101672 A EA201101672 A EA 201101672A EA 201101672 A1 EA201101672 A1 EA 201101672A1
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EA
Eurasian Patent Office
Prior art keywords
aminoisal
neprilisin
inhibitors
acid
substituted derivatives
Prior art date
Application number
EA201101672A
Other languages
English (en)
Inventor
Гэри Марк Коппола
Юки Иваки
Раджешри Ганеш Карки
Тошио Каванами
Гэри Майкл Ксандер
Мунето Моги
Роберт Сан
Original Assignee
Новартис Аг
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201101672A1 publication Critical patent/EA201101672A1/ru

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Abstract

В заявке описаны соединение формулы I'или его фармацевтически приемлемая соль, в которой R, R, R, Х и n определены в настоящей заявке. В заявке также описаны способ получения соединений, предлагаемых в настоящем изобретении, и их применение в терапии. В заявке также описаны комбинация фармакологически активных средств и фармацевтическая композиция.
EA201101672A 2009-05-28 2010-05-26 Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина EA201101672A1 (ru)

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RU2756223C2 (ru) * 2016-03-08 2021-09-28 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Кристаллическая (2s,4r)-5-(5'-хлор-2'-фтор-[1,1'-бифенил]-4-ил)-2-(этоксиметил)-4-(3-гидроксиизоксазол-5-карбоксамидо)-2-метилпентановая кислота и ее применения

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