EA200801998A1 - ПИРИДИН[3,4-b]ПИРАЗИНОНЫ - Google Patents

ПИРИДИН[3,4-b]ПИРАЗИНОНЫ

Info

Publication number
EA200801998A1
EA200801998A1 EA200801998A EA200801998A EA200801998A1 EA 200801998 A1 EA200801998 A1 EA 200801998A1 EA 200801998 A EA200801998 A EA 200801998A EA 200801998 A EA200801998 A EA 200801998A EA 200801998 A1 EA200801998 A1 EA 200801998A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
пирддин
пиразиноны
disclosed
methods
Prior art date
Application number
EA200801998A
Other languages
English (en)
Other versions
EA014919B1 (ru
Inventor
Роберт О. Хьюгс
Эндрю Саймон Белл
Дэвид Грэхем Браун
Дэфидд Рис Оуэн
Майкл Джон Палмер
Кристофер Филлипс
Дэвид Луис Браун
Иветта Марлин Фобиан
Джон Николас Фрескос
Стивен Эдвард Хисли
Эрик Джон Джейкобсен
Тодд Майкл Мэддакс
Брент Вирджил Мишке
Джон Мэйджор Молино
Джозеф Блэр Мун
Дональд Джозеф мл. Роджьер
Майкл Брент Толлефсон
Джон Кейт Уолкер
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200801998A1 publication Critical patent/EA200801998A1/ru
Publication of EA014919B1 publication Critical patent/EA014919B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Раскрыты соединения и фармацевтически приемлемые соли соединений, где указанные соединения имеют структуру формулы Iгде R, RRи Rявляются такими, как определено в описании изобретения. Также раскрыты соответствующие фармацевтические композиции, способы лечения, способы синтеза и промежуточные соединения.
EA200801998A 2006-04-21 2007-04-10 ПИРИДИН[3,4-b]ПИРАЗИНОНЫ EA014919B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79397106P 2006-04-21 2006-04-21
PCT/IB2007/001001 WO2007122466A1 (en) 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones

Publications (2)

Publication Number Publication Date
EA200801998A1 true EA200801998A1 (ru) 2009-04-28
EA014919B1 EA014919B1 (ru) 2011-04-29

Family

ID=38431249

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801998A EA014919B1 (ru) 2006-04-21 2007-04-10 ПИРИДИН[3,4-b]ПИРАЗИНОНЫ

Country Status (42)

Country Link
US (1) US7902195B2 (ru)
EP (1) EP2013208B1 (ru)
JP (1) JP4436892B2 (ru)
KR (1) KR101061328B1 (ru)
CN (1) CN101454320B (ru)
AP (1) AP2408A (ru)
AR (1) AR060525A1 (ru)
AT (1) ATE513831T1 (ru)
AU (1) AU2007242555B2 (ru)
BR (1) BRPI0710658A2 (ru)
CA (1) CA2649775C (ru)
CR (1) CR10327A (ru)
CU (1) CU23777B7 (ru)
CY (1) CY1111739T1 (ru)
DK (1) DK2013208T3 (ru)
DO (1) DOP2007000080A (ru)
EA (1) EA014919B1 (ru)
EC (1) ECSP088803A (ru)
ES (1) ES2366239T3 (ru)
GT (1) GT200700035A (ru)
HK (1) HK1133875A1 (ru)
HR (1) HRP20110539T1 (ru)
IL (1) IL194591A (ru)
MA (1) MA30352B1 (ru)
ME (1) MEP23808A (ru)
MX (1) MX2008012456A (ru)
MY (1) MY148583A (ru)
NL (1) NL2000583C2 (ru)
NO (1) NO20084129L (ru)
NZ (1) NZ571540A (ru)
PA (1) PA8724201A1 (ru)
PE (1) PE20080192A1 (ru)
PL (1) PL2013208T3 (ru)
RS (2) RS51885B (ru)
SI (1) SI2013208T1 (ru)
SV (1) SV2008003074A (ru)
TN (1) TNSN08408A1 (ru)
TW (1) TWI337609B (ru)
UA (1) UA92637C2 (ru)
UY (1) UY30291A1 (ru)
WO (1) WO2007122466A1 (ru)
ZA (1) ZA200808283B (ru)

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JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
KR102061952B1 (ko) 2014-08-06 2020-01-02 화이자 인코포레이티드 이미다조피리다진 화합물
KR102000382B1 (ko) 2015-02-03 2019-07-15 화이자 인코포레이티드 신규 시클로프로파벤조푸라닐 피리도피라진디온
CA2989456C (en) 2015-06-17 2022-01-04 Pfizer Inc. Tricyclic compounds and their use as phosphodiesterase inhibitors
EP3353174A1 (en) 2015-09-24 2018-08-01 Pfizer Inc N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl]amides useful as bace inhibitors
BR112018003489A2 (pt) 2015-09-24 2018-09-25 Pfizer n-[2-(2-amino-6,6-dissubstituído-4,4a,5,6-tetra-hidropirano[3,4-d][1,3]tiazin-8a(8h)-il)-1,3-tiazol-4-il]amidas
WO2017051303A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
RU2719599C2 (ru) 2016-02-23 2020-04-21 Пфайзер Инк. Соединения 6, 7-дигидро-5H-пиразоло[5,1-b][1,3]оксазин-2-карбоксамида
JP7046018B2 (ja) 2016-07-01 2022-04-01 ファイザー・インク 神経性疾患および神経変性疾患を処置するための５，７－ジヒドロピロロピリジン誘導体
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RU2557242C2 (ru) * 2009-10-26 2015-07-20 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Способы получения и очистки гетероарильных соединений

Also Published As

Publication number Publication date
MA30352B1 (fr) 2009-04-01
MY148583A (en) 2013-04-30
PE20080192A1 (es) 2008-03-01
NO20084129L (no) 2008-10-29
ES2366239T3 (es) 2011-10-18
CU20080194A7 (es) 2011-03-21
TW200808794A (en) 2008-02-16
MX2008012456A (es) 2008-10-10
PL2013208T3 (pl) 2011-10-31
WO2007122466A1 (en) 2007-11-01
CN101454320A (zh) 2009-06-10
DOP2007000080A (es) 2007-11-15
ECSP088803A (es) 2008-11-27
SV2008003074A (es) 2010-01-12
US20070249615A1 (en) 2007-10-25
CY1111739T1 (el) 2015-10-07
TWI337609B (en) 2011-02-21
CU23777B7 (es) 2012-02-15
AU2007242555A1 (en) 2007-11-01
NL2000583C2 (nl) 2007-12-14
UA92637C2 (en) 2010-11-25
TNSN08408A1 (fr) 2010-04-14
EA014919B1 (ru) 2011-04-29
US7902195B2 (en) 2011-03-08
IL194591A (en) 2012-07-31
NZ571540A (en) 2010-10-29
UY30291A1 (es) 2007-11-30
AR060525A1 (es) 2008-06-25
NL2000583A1 (nl) 2007-10-23
HRP20110539T1 (hr) 2011-08-31
ATE513831T1 (de) 2011-07-15
RS20080484A (en) 2009-07-15
KR101061328B1 (ko) 2011-08-31
EP2013208A1 (en) 2009-01-14
BRPI0710658A2 (pt) 2011-08-16
CA2649775A1 (en) 2007-11-01
GT200700035A (es) 2008-02-05
CA2649775C (en) 2011-05-31
HK1133875A1 (en) 2010-04-09
DK2013208T3 (da) 2011-08-15
ZA200808283B (en) 2009-11-25
JP4436892B2 (ja) 2010-03-24
KR20080110930A (ko) 2008-12-19
MEP23808A (en) 2010-06-10
JP2009534368A (ja) 2009-09-24
EP2013208B1 (en) 2011-06-22
RS51885B (en) 2012-02-29
PA8724201A1 (es) 2009-08-26
AU2007242555B2 (en) 2010-12-16
CR10327A (es) 2008-10-21
AP2008004640A0 (en) 2008-10-31
SI2013208T1 (sl) 2011-09-30
AP2408A (en) 2012-05-30
CN101454320B (zh) 2012-12-19

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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