ECSP088803A - PIRIDIN[3,4-b]PIRAZINONAS - Google Patents

PIRIDIN[3,4-b]PIRAZINONAS

Info

Publication number
ECSP088803A
ECSP088803A EC2008008803A ECSP088803A ECSP088803A EC SP088803 A ECSP088803 A EC SP088803A EC 2008008803 A EC2008008803 A EC 2008008803A EC SP088803 A ECSP088803 A EC SP088803A EC SP088803 A ECSP088803 A EC SP088803A
Authority
EC
Ecuador
Prior art keywords
compounds
pirazinonas
piridin
disclosed
procedures
Prior art date
Application number
EC2008008803A
Other languages
English (en)
Inventor
John Freskos
Joseph B Moon
John Walker
Robert Hughes
Eric Jon Jacobsen
David Graham Brown
Michael John Palmer
Christopher Phillips
Andrew Simon Bell
Yvette M Fobian
Michael B Tollefson
Brent V Mischke
Dafydd Rhys Owen
David Louis Brow
Steven Edward Heasley
Todd Michael Maddux
John Major Molyneaux
Donald Joseph Rogier Jr
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ECSP088803A publication Critical patent/ECSP088803A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

RESUMENSe dan a conocer compuestos y sales farmacéuticamente aceptables de los compuestos, en los que los compuestos tienen la estructura de Fórmula I: en la que R2, R6A, R6B, y R8 son como se definen en esta memoria descriptiva. Se dan a conocer también las correspondientes composiciones farmacéuticas, procedimientos de tratamiento, procedimientos sintéticos e intermedios.
EC2008008803A 2006-04-21 2008-10-08 PIRIDIN[3,4-b]PIRAZINONAS ECSP088803A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79397106P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
ECSP088803A true ECSP088803A (es) 2008-11-27

Family

ID=38431249

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008803A ECSP088803A (es) 2006-04-21 2008-10-08 PIRIDIN[3,4-b]PIRAZINONAS

Country Status (42)

Country Link
US (1) US7902195B2 (es)
EP (1) EP2013208B1 (es)
JP (1) JP4436892B2 (es)
KR (1) KR101061328B1 (es)
CN (1) CN101454320B (es)
AP (1) AP2408A (es)
AR (1) AR060525A1 (es)
AT (1) ATE513831T1 (es)
AU (1) AU2007242555B2 (es)
BR (1) BRPI0710658A2 (es)
CA (1) CA2649775C (es)
CR (1) CR10327A (es)
CU (1) CU23777B7 (es)
CY (1) CY1111739T1 (es)
DK (1) DK2013208T3 (es)
DO (1) DOP2007000080A (es)
EA (1) EA014919B1 (es)
EC (1) ECSP088803A (es)
ES (1) ES2366239T3 (es)
GT (1) GT200700035A (es)
HK (1) HK1133875A1 (es)
HR (1) HRP20110539T1 (es)
IL (1) IL194591A (es)
MA (1) MA30352B1 (es)
ME (1) MEP23808A (es)
MX (1) MX2008012456A (es)
MY (1) MY148583A (es)
NL (1) NL2000583C2 (es)
NO (1) NO20084129L (es)
NZ (1) NZ571540A (es)
PA (1) PA8724201A1 (es)
PE (1) PE20080192A1 (es)
PL (1) PL2013208T3 (es)
RS (2) RS51885B (es)
SI (1) SI2013208T1 (es)
SV (1) SV2008003074A (es)
TN (1) TNSN08408A1 (es)
TW (1) TWI337609B (es)
UA (1) UA92637C2 (es)
UY (1) UY30291A1 (es)
WO (1) WO2007122466A1 (es)
ZA (1) ZA200808283B (es)

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BRPI0908569B8 (pt) 2008-03-05 2021-05-25 Merck Patent Gmbh estimuladores de secreção de insulina derivados de piridopirazinonas, seu uso, e composição farmacêutica
EP2351748A4 (en) * 2008-10-09 2012-03-21 Kyorin Seiyaku Kk ISOCHINOLINE DERIVATIVES AND THESE PDE INHIBITORS CONTAINING ACTIVE SUBSTANCE
RU2557242C2 (ru) * 2009-10-26 2015-07-20 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Способы получения и очистки гетероарильных соединений
TWI542580B (zh) 2010-10-15 2016-07-21 基利科學股份有限公司 治療肺高血壓的組合物及方法
WO2012131539A1 (en) 2011-03-31 2012-10-04 Pfizer Inc. Novel bicyclic pyridinones
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
JP6043355B2 (ja) 2011-08-31 2016-12-14 ファイザー・インク ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
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UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
WO2014091352A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
US9403846B2 (en) 2012-12-19 2016-08-02 Pfizer Inc. Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CA2897678A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
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CA2925743C (en) 2013-10-04 2018-03-06 Pfizer Inc. Novel bicyclic pyridinones as gamma-secretase modulators
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
MD20160102A2 (ro) 2014-04-01 2017-04-30 Pfizer Inc. Cromen şi 1,1a,2,7b-tetrahidrociclopropa[c]cromen piridopirazindione ca modulatori ai gama-secretazei
AP2016009493A0 (en) 2014-04-10 2016-10-31 Pfizer 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES
EP3172210B1 (en) 2014-07-24 2020-01-15 Pfizer Inc Pyrazolopyrimidine compounds
KR102061952B1 (ko) 2014-08-06 2020-01-02 화이자 인코포레이티드 이미다조피리다진 화합물
PE20171318A1 (es) 2015-02-03 2017-09-07 Pfizer Ciclopropabenzofuranil-piridopirazindionas novedosas
WO2016203347A1 (en) 2015-06-17 2016-12-22 Pfizer Inc. Tricyclic compounds and their use as phosphodiesterase inhibitors
WO2017051276A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
JP2018531924A (ja) 2015-09-24 2018-11-01 ファイザー・インク テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
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Also Published As

Publication number Publication date
RS51885B (en) 2012-02-29
TNSN08408A1 (fr) 2010-04-14
PL2013208T3 (pl) 2011-10-31
HK1133875A1 (en) 2010-04-09
PA8724201A1 (es) 2009-08-26
PE20080192A1 (es) 2008-03-01
EP2013208B1 (en) 2011-06-22
KR20080110930A (ko) 2008-12-19
DK2013208T3 (da) 2011-08-15
DOP2007000080A (es) 2007-11-15
ZA200808283B (en) 2009-11-25
MX2008012456A (es) 2008-10-10
ES2366239T3 (es) 2011-10-18
MEP23808A (en) 2010-06-10
CY1111739T1 (el) 2015-10-07
TW200808794A (en) 2008-02-16
CA2649775A1 (en) 2007-11-01
EA014919B1 (ru) 2011-04-29
EP2013208A1 (en) 2009-01-14
US7902195B2 (en) 2011-03-08
WO2007122466A1 (en) 2007-11-01
AR060525A1 (es) 2008-06-25
NL2000583C2 (nl) 2007-12-14
UA92637C2 (en) 2010-11-25
NZ571540A (en) 2010-10-29
AU2007242555B2 (en) 2010-12-16
CR10327A (es) 2008-10-21
CA2649775C (en) 2011-05-31
GT200700035A (es) 2008-02-05
SI2013208T1 (sl) 2011-09-30
RS20080484A (en) 2009-07-15
JP2009534368A (ja) 2009-09-24
CU20080194A7 (es) 2011-03-21
US20070249615A1 (en) 2007-10-25
CU23777B7 (es) 2012-02-15
BRPI0710658A2 (pt) 2011-08-16
AP2008004640A0 (en) 2008-10-31
NO20084129L (no) 2008-10-29
UY30291A1 (es) 2007-11-30
ATE513831T1 (de) 2011-07-15
MA30352B1 (fr) 2009-04-01
TWI337609B (en) 2011-02-21
AU2007242555A1 (en) 2007-11-01
HRP20110539T1 (hr) 2011-08-31
EA200801998A1 (ru) 2009-04-28
IL194591A (en) 2012-07-31
SV2008003074A (es) 2010-01-12
JP4436892B2 (ja) 2010-03-24
KR101061328B1 (ko) 2011-08-31
MY148583A (en) 2013-04-30
CN101454320A (zh) 2009-06-10
AP2408A (en) 2012-05-30
CN101454320B (zh) 2012-12-19
NL2000583A1 (nl) 2007-10-23

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