CR10327A - "PIRIDIN(3-4-b) PIRAZINONAS" - Google Patents

"PIRIDIN(3-4-b) PIRAZINONAS"

Info

Publication number
CR10327A
CR10327A CR10327A CR10327A CR10327A CR 10327 A CR10327 A CR 10327A CR 10327 A CR10327 A CR 10327A CR 10327 A CR10327 A CR 10327A CR 10327 A CR10327 A CR 10327A
Authority
CR
Costa Rica
Prior art keywords
compounds
pirazinonas
piridin
disclosed
procedures
Prior art date
Application number
CR10327A
Other languages
English (en)
Inventor
Robert O Hughes
Andrew Simon Bell
David Graham Brown
Dafydd Rhys Owen
Michael John Palmer
Christopher Phillips
David Louis Brown
Yvette Marlene Fobian
John Nicholas Freskos
Steven Edward Heasley
Eric Jon Jacobsen
Todd Michael Maddux
Brent Virgil Mischke
John Major Molyneaux
Joseph Blair Moon
Donald Joseph Rogier
Michael Brent Tollefson
John Keith Walker
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR10327A publication Critical patent/CR10327A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Se dan a conocer compuestos y sales farmaceuticamente aceptables de los compuestos, en los que los compuestos tienen la estructura de Formula I: en la que R2, R6A y R8 son como se definen en esta memoria descriptiva. Se dan a conocer tambien las correspondientes composiciones farmaceuticas, procedimientos de tratamiento, procedimientos sinteticos e intermedios.
CR10327A 2006-04-21 2008-09-30 "PIRIDIN(3-4-b) PIRAZINONAS" CR10327A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79397106P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
CR10327A true CR10327A (es) 2008-10-21

Family

ID=38431249

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10327A CR10327A (es) 2006-04-21 2008-09-30 "PIRIDIN(3-4-b) PIRAZINONAS"

Country Status (42)

Country Link
US (1) US7902195B2 (es)
EP (1) EP2013208B1 (es)
JP (1) JP4436892B2 (es)
KR (1) KR101061328B1 (es)
CN (1) CN101454320B (es)
AP (1) AP2408A (es)
AR (1) AR060525A1 (es)
AT (1) ATE513831T1 (es)
AU (1) AU2007242555B2 (es)
BR (1) BRPI0710658A2 (es)
CA (1) CA2649775C (es)
CR (1) CR10327A (es)
CU (1) CU23777B7 (es)
CY (1) CY1111739T1 (es)
DK (1) DK2013208T3 (es)
DO (1) DOP2007000080A (es)
EA (1) EA014919B1 (es)
EC (1) ECSP088803A (es)
ES (1) ES2366239T3 (es)
GT (1) GT200700035A (es)
HK (1) HK1133875A1 (es)
HR (1) HRP20110539T1 (es)
IL (1) IL194591A (es)
MA (1) MA30352B1 (es)
ME (1) MEP23808A (es)
MX (1) MX2008012456A (es)
MY (1) MY148583A (es)
NL (1) NL2000583C2 (es)
NO (1) NO20084129L (es)
NZ (1) NZ571540A (es)
PA (1) PA8724201A1 (es)
PE (1) PE20080192A1 (es)
PL (1) PL2013208T3 (es)
RS (2) RS51885B (es)
SI (1) SI2013208T1 (es)
SV (1) SV2008003074A (es)
TN (1) TNSN08408A1 (es)
TW (1) TWI337609B (es)
UA (1) UA92637C2 (es)
UY (1) UY30291A1 (es)
WO (1) WO2007122466A1 (es)
ZA (1) ZA200808283B (es)

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SI2013208T1 (sl) 2006-04-21 2011-09-30 Pfizer Prod Inc Piridin(3,4-b)pirazinoni
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EA020372B1 (ru) * 2008-03-05 2014-10-30 Мерк Патент Гмбх Стимуляторы секреции инсулина - производные пиридопиразинонов, способы их получения и их применение для лечения диабета
EP2351748A4 (en) * 2008-10-09 2012-03-21 Kyorin Seiyaku Kk ISOCHINOLINE DERIVATIVES AND THESE PDE INHIBITORS CONTAINING ACTIVE SUBSTANCE
CN102686225A (zh) * 2009-10-26 2012-09-19 西格诺药品有限公司 杂芳基化合物的合成和纯化方法
PL2637664T3 (pl) 2010-10-15 2017-09-29 Gilead Sciences, Inc. Kompozycje i metody leczenia nadciśnienia płucnego
EP2691393B1 (en) 2011-03-31 2016-09-14 Pfizer Inc Novel bicyclic pyridinones
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
EP2751116B1 (en) 2011-08-31 2016-10-12 Pfizer Inc Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
CA2872154C (en) 2012-05-04 2016-08-23 Pfizer Inc. Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2
EP2897964A1 (en) 2012-09-20 2015-07-29 Pfizer Inc. Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
WO2014091352A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
JP6162820B2 (ja) 2012-12-19 2017-07-12 ファイザー・インク 炭素環式および複素環式置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
CA2897678A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CN105121439A (zh) 2013-02-19 2015-12-02 辉瑞公司 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物
EP3052495B1 (en) 2013-10-04 2019-06-26 Pfizer Inc Novel bicyclic pyridinones as gamma-secretase modulators
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
CR20160454A (es) 2014-04-01 2016-12-06 Pfizer CROMENO Y 1,1 a,2,7b—TETRAHIDROCICLOPROPA[C]CROMENO PIRIDOPIRAZINADIONAS NOVEDOSAS
PE20170327A1 (es) 2014-04-10 2017-04-21 Pfizer 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4d] [1,3] TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILAMIDAS
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
PE20170295A1 (es) 2014-08-06 2017-03-30 Pfizer Compuestos de imidazopiridazina
EP3253755B1 (en) 2015-02-03 2020-08-26 Pfizer Inc Novel cyclopropabenzofuranyl pyridopyrazinediones
CR20170572A (es) 2015-06-17 2018-03-20 Pfizer Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa
JP2018531923A (ja) 2015-09-24 2018-11-01 ファイザー・インク Ｎ−［２−（２−アミノ−６，６−二置換−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル）−１，３−チアゾール−４−イル］アミド
EP3353182A1 (en) 2015-09-24 2018-08-01 Pfizer Inc Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
PL3419979T3 (pl) 2016-02-23 2020-06-29 Pfizer Inc. Związki 6,7-dihydro-5h-pirazolo[5,1-b][1,3]oksazyno-2- karboksyamidowe
JP7046018B2 (ja) 2016-07-01 2022-04-01 ファイザー・インク 神経性疾患および神経変性疾患を処置するための５，７－ジヒドロピロロピリジン誘導体
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Also Published As

Publication number Publication date
US20070249615A1 (en) 2007-10-25
EA200801998A1 (ru) 2009-04-28
US7902195B2 (en) 2011-03-08
ZA200808283B (en) 2009-11-25
AU2007242555B2 (en) 2010-12-16
WO2007122466A1 (en) 2007-11-01
PE20080192A1 (es) 2008-03-01
CU23777B7 (es) 2012-02-15
NL2000583C2 (nl) 2007-12-14
UA92637C2 (en) 2010-11-25
ES2366239T3 (es) 2011-10-18
AU2007242555A1 (en) 2007-11-01
NO20084129L (no) 2008-10-29
CN101454320A (zh) 2009-06-10
KR20080110930A (ko) 2008-12-19
EP2013208A1 (en) 2009-01-14
UY30291A1 (es) 2007-11-30
CY1111739T1 (el) 2015-10-07
KR101061328B1 (ko) 2011-08-31
EP2013208B1 (en) 2011-06-22
SV2008003074A (es) 2010-01-12
NZ571540A (en) 2010-10-29
NL2000583A1 (nl) 2007-10-23
CA2649775C (en) 2011-05-31
EA014919B1 (ru) 2011-04-29
TNSN08408A1 (fr) 2010-04-14
MX2008012456A (es) 2008-10-10
AP2008004640A0 (en) 2008-10-31
TWI337609B (en) 2011-02-21
JP4436892B2 (ja) 2010-03-24
AP2408A (en) 2012-05-30
CN101454320B (zh) 2012-12-19
GT200700035A (es) 2008-02-05
JP2009534368A (ja) 2009-09-24
MY148583A (en) 2013-04-30
CU20080194A7 (es) 2011-03-21
RS51885B (en) 2012-02-29
PA8724201A1 (es) 2009-08-26
DK2013208T3 (da) 2011-08-15
CA2649775A1 (en) 2007-11-01
HRP20110539T1 (hr) 2011-08-31
HK1133875A1 (en) 2010-04-09
DOP2007000080A (es) 2007-11-15
ATE513831T1 (de) 2011-07-15
TW200808794A (en) 2008-02-16
IL194591A (en) 2012-07-31
SI2013208T1 (sl) 2011-09-30
PL2013208T3 (pl) 2011-10-31
MEP23808A (en) 2010-06-10
AR060525A1 (es) 2008-06-25
MA30352B1 (fr) 2009-04-01
RS20080484A (en) 2009-07-15
BRPI0710658A2 (pt) 2011-08-16
ECSP088803A (es) 2008-11-27

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