AP2408A - Pyridine[3,4-B]pyrazinones. - Google Patents

Pyridine[3,4-B]pyrazinones.

Info

Publication number
AP2408A
AP2408A AP2008004640A AP2008004640A AP2408A AP 2408 A AP2408 A AP 2408A AP 2008004640 A AP2008004640 A AP 2008004640A AP 2008004640 A AP2008004640 A AP 2008004640A AP 2408 A AP2408 A AP 2408A
Authority
AP
ARIPO
Prior art keywords
pyrazinones
pyridine
Prior art date
Application number
AP2008004640A
Other languages
English (en)
Other versions
AP2008004640A0 (en
Inventor
Andrew Simon Bell
David Louis Brown
David Graham Brown
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2008004640A0 publication Critical patent/AP2008004640A0/xx
Application granted granted Critical
Publication of AP2408A publication Critical patent/AP2408A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2008004640A 2006-04-21 2007-04-10 Pyridine[3,4-B]pyrazinones. AP2408A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79397106P 2006-04-21 2006-04-21
PCT/IB2007/001001 WO2007122466A1 (en) 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones

Publications (2)

Publication Number Publication Date
AP2008004640A0 AP2008004640A0 (en) 2008-10-31
AP2408A true AP2408A (en) 2012-05-30

Family

ID=38431249

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004640A AP2408A (en) 2006-04-21 2007-04-10 Pyridine[3,4-B]pyrazinones.

Country Status (42)

Country Link
US (1) US7902195B2 (es)
EP (1) EP2013208B1 (es)
JP (1) JP4436892B2 (es)
KR (1) KR101061328B1 (es)
CN (1) CN101454320B (es)
AP (1) AP2408A (es)
AR (1) AR060525A1 (es)
AT (1) ATE513831T1 (es)
AU (1) AU2007242555B2 (es)
BR (1) BRPI0710658A2 (es)
CA (1) CA2649775C (es)
CR (1) CR10327A (es)
CU (1) CU23777B7 (es)
CY (1) CY1111739T1 (es)
DK (1) DK2013208T3 (es)
DO (1) DOP2007000080A (es)
EA (1) EA014919B1 (es)
EC (1) ECSP088803A (es)
ES (1) ES2366239T3 (es)
GT (1) GT200700035A (es)
HK (1) HK1133875A1 (es)
HR (1) HRP20110539T1 (es)
IL (1) IL194591A (es)
MA (1) MA30352B1 (es)
ME (1) MEP23808A (es)
MX (1) MX2008012456A (es)
MY (1) MY148583A (es)
NL (1) NL2000583C2 (es)
NO (1) NO20084129L (es)
NZ (1) NZ571540A (es)
PA (1) PA8724201A1 (es)
PE (1) PE20080192A1 (es)
PL (1) PL2013208T3 (es)
RS (2) RS20080484A (es)
SI (1) SI2013208T1 (es)
SV (1) SV2008003074A (es)
TN (1) TNSN08408A1 (es)
TW (1) TWI337609B (es)
UA (1) UA92637C2 (es)
UY (1) UY30291A1 (es)
WO (1) WO2007122466A1 (es)
ZA (1) ZA200808283B (es)

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HUE025355T2 (en) * 2006-12-12 2016-02-29 Gilead Sciences Inc Composition for treating pulmonary hypertension
HUE033849T2 (en) * 2008-03-05 2018-01-29 Merck Patent Gmbh Pyridopyrazinone derivative for insulin secretagogues, methods for their preparation and their use in the treatment of diabetes
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MX341704B (es) * 2009-10-26 2016-08-31 Signal Pharm Llc Métodos de síntesis y purificación de compuestos de heteroarilo.
RS56135B1 (sr) 2010-10-15 2017-10-31 Gilead Sciences Kompozicije i metode za lečenje plućne hipertenzije
CA2830027C (en) 2011-03-31 2016-04-26 Pfizer Inc. Novel bicyclic pyridinones
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
ES2605565T3 (es) 2011-08-31 2017-03-15 Pfizer Inc Compuestos de hexahidropirano [3,4-D][1,3]tiazin-2-amina
ES2585262T3 (es) 2012-05-04 2016-10-04 Pfizer Inc Compuestos heterocíclicos de hexahidropiran[3,4-d][1,3]tiazin-2-amina sustituidos como inhibidores de PPA, BACE1 y BACE2
EP2897964A1 (en) 2012-09-20 2015-07-29 Pfizer Inc. Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
CA2893256A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
WO2014097038A1 (en) 2012-12-19 2014-06-26 Pfizer Inc. CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS
WO2014125394A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
PE20151332A1 (es) 2013-02-19 2015-09-20 Pfizer Compuestos de azabencimidazol
ES2742078T3 (es) 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
JO3466B1 (ar) 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
ES2759277T3 (es) 2014-04-01 2020-05-08 Pfizer Cromeno y 1,1a,2,7b-tetrahidrociclopropa[c]cromeno piridopiracinadionionas como moduladores de gamma-secretasa
AP2016009493A0 (en) 2014-04-10 2016-10-31 Pfizer 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
KR102061952B1 (ko) 2014-08-06 2020-01-02 화이자 인코포레이티드 이미다조피리다진 화합물
EP3253755B1 (en) 2015-02-03 2020-08-26 Pfizer Inc Novel cyclopropabenzofuranyl pyridopyrazinediones
KR102426986B1 (ko) 2015-06-17 2022-07-28 화이자 인코포레이티드 삼환형 화합물 및 포스포다이에스터라제 억제제로서 이의 용도
JP2018531924A (ja) 2015-09-24 2018-11-01 ファイザー・インク テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
JP2018534251A (ja) 2015-09-24 2018-11-22 ファイザー・インク Ｂａｃｅ阻害剤として有用なｎ−［２−（３−アミノ−２，５−ジメチル−１，１−ジオキシド−５，６−ジヒドロ−２ｈ−１，２，４−チアジアジン−５−イル）−１，３−チアゾール−４−イル］アミド
EP3353183A1 (en) 2015-09-24 2018-08-01 Pfizer Inc N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3]thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl]amides
KR102148587B1 (ko) 2016-02-23 2020-08-26 화이자 인코포레이티드 6,7-디히드로-5H-피라졸로[5,1-b][1,3]옥사진-2-카르복스아미드 화합물
EP3872078A1 (en) 2016-07-01 2021-09-01 Pfizer Inc. 5,7-dihydro-pyrrolo-pyridine derivatives for use in the treament of depression, anxiety or panic disorders
MX2019015371A (es) 2017-06-22 2020-07-20 Pfizer Derivados de dihidro-pirrolo-piridina.
CA3067591A1 (en) * 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
CA3094366A1 (en) 2018-03-23 2019-09-26 Pfizer Inc. Piperazine azaspiro derivatives
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors

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US20020147199A1 (en) * 2000-03-14 2002-10-10 Degenhard Marx Process for the treatment of erectile dysfunction and product therefor
EP1364950A1 (en) * 2001-02-26 2003-11-26 Tanabe Seiyaku Co., Ltd. Pyridopyrimidine or naphthyridine derivative
WO2006126082A2 (en) * 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors

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Patent Citations (3)

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US20020147199A1 (en) * 2000-03-14 2002-10-10 Degenhard Marx Process for the treatment of erectile dysfunction and product therefor
EP1364950A1 (en) * 2001-02-26 2003-11-26 Tanabe Seiyaku Co., Ltd. Pyridopyrimidine or naphthyridine derivative
WO2006126082A2 (en) * 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors

Also Published As

Publication number Publication date
CN101454320A (zh) 2009-06-10
CU20080194A7 (es) 2011-03-21
MEP23808A (en) 2010-06-10
TW200808794A (en) 2008-02-16
GT200700035A (es) 2008-02-05
DOP2007000080A (es) 2007-11-15
NZ571540A (en) 2010-10-29
RS51885B (en) 2012-02-29
KR20080110930A (ko) 2008-12-19
US20070249615A1 (en) 2007-10-25
MA30352B1 (fr) 2009-04-01
EP2013208B1 (en) 2011-06-22
ATE513831T1 (de) 2011-07-15
BRPI0710658A2 (pt) 2011-08-16
IL194591A (en) 2012-07-31
EP2013208A1 (en) 2009-01-14
MX2008012456A (es) 2008-10-10
ECSP088803A (es) 2008-11-27
CA2649775A1 (en) 2007-11-01
NO20084129L (no) 2008-10-29
HK1133875A1 (en) 2010-04-09
ES2366239T3 (es) 2011-10-18
HRP20110539T1 (hr) 2011-08-31
AP2008004640A0 (en) 2008-10-31
KR101061328B1 (ko) 2011-08-31
AU2007242555B2 (en) 2010-12-16
NL2000583A1 (nl) 2007-10-23
NL2000583C2 (nl) 2007-12-14
UA92637C2 (en) 2010-11-25
DK2013208T3 (da) 2011-08-15
TWI337609B (en) 2011-02-21
PA8724201A1 (es) 2009-08-26
EA200801998A1 (ru) 2009-04-28
MY148583A (en) 2013-04-30
EA014919B1 (ru) 2011-04-29
ZA200808283B (en) 2009-11-25
US7902195B2 (en) 2011-03-08
SI2013208T1 (sl) 2011-09-30
CA2649775C (en) 2011-05-31
AU2007242555A1 (en) 2007-11-01
CU23777B7 (es) 2012-02-15
CY1111739T1 (el) 2015-10-07
CN101454320B (zh) 2012-12-19
UY30291A1 (es) 2007-11-30
CR10327A (es) 2008-10-21
WO2007122466A1 (en) 2007-11-01
PL2013208T3 (pl) 2011-10-31
RS20080484A (en) 2009-07-15
JP4436892B2 (ja) 2010-03-24
TNSN08408A1 (fr) 2010-04-14
PE20080192A1 (es) 2008-03-01
JP2009534368A (ja) 2009-09-24
AR060525A1 (es) 2008-06-25
SV2008003074A (es) 2010-01-12

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