EA201400724A1 - Комбинация (3s,3s') 4,4'-дисульфандиилбис (3-аминобутан-1-сульфокислоты) и второго антигипертензивного средства - Google Patents

Комбинация (3s,3s') 4,4'-дисульфандиилбис (3-аминобутан-1-сульфокислоты) и второго антигипертензивного средства

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Publication number
EA201400724A1
EA201400724A1 EA201400724A EA201400724A EA201400724A1 EA 201400724 A1 EA201400724 A1 EA 201400724A1 EA 201400724 A EA201400724 A EA 201400724A EA 201400724 A EA201400724 A EA 201400724A EA 201400724 A1 EA201400724 A1 EA 201400724A1
Authority
EA
Eurasian Patent Office
Prior art keywords
combination
sulpheic
disulfandiilbis
aminobutan
antihypertensive
Prior art date
Application number
EA201400724A
Other languages
English (en)
Other versions
EA028718B1 (ru
Inventor
Кэтрин Ллоренс-Кортес
Янник Марк
Джи Гао-Дельен
Фабрис Балавуан
Лионель Сегар
Original Assignee
Квантум Дженомикс
Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Квантум Дженомикс, Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) filed Critical Квантум Дженомикс
Publication of EA201400724A1 publication Critical patent/EA201400724A1/ru
Publication of EA028718B1 publication Critical patent/EA028718B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к фармацевтической композиции, включающей, по меньшей мере, в одном фармацевтически приемлемом носителе комбинацию (3S,3S') 4,4'-дисульфандиилбис(3-аминобутан 1-сульфокислоты) или ее фармацевтически приемлемой соли или сольвата и второго активного ингредиента, который выбирают из группы, состоящей из ингибиторов ангиотензин-I-превращающего фермента и антагонистов рецепторов 1-го типа ангиотензина II. Указанная композиция особенно полезна для лечения гипертензии и связанных с ней заболеваний и состояний.
EA201400724A 2011-12-21 2012-12-21 Способ лечения артериальной гипертензии или косвенно или прямо связанных заболеваний EA028718B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306735 2011-12-21
EP11306735.9 2011-12-21
PCT/EP2012/076607 WO2013092984A1 (en) 2011-12-21 2012-12-21 Combination of (3s,3s') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent

Publications (2)

Publication Number Publication Date
EA201400724A1 true EA201400724A1 (ru) 2014-09-30
EA028718B1 EA028718B1 (ru) 2017-12-29

Family

ID=47522577

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400724A EA028718B1 (ru) 2011-12-21 2012-12-21 Способ лечения артериальной гипертензии или косвенно или прямо связанных заболеваний

Country Status (25)

Country Link
US (1) US10959938B2 (ru)
EP (1) EP2793878B1 (ru)
JP (2) JP6212500B2 (ru)
KR (1) KR20140116879A (ru)
CN (2) CN104220062B (ru)
AU (1) AU2012356895B2 (ru)
BR (1) BR112014015276B1 (ru)
CA (1) CA2859704C (ru)
CY (1) CY1118711T1 (ru)
DK (1) DK2793878T3 (ru)
EA (1) EA028718B1 (ru)
ES (1) ES2619027T3 (ru)
HK (1) HK1203051A1 (ru)
HR (1) HRP20170267T1 (ru)
HU (1) HUE033403T2 (ru)
IL (1) IL233156B (ru)
IN (1) IN2014DN05787A (ru)
LT (1) LT2793878T (ru)
MX (1) MX345469B (ru)
PL (1) PL2793878T3 (ru)
PT (1) PT2793878T (ru)
RS (1) RS55774B1 (ru)
SI (1) SI2793878T1 (ru)
WO (1) WO2013092984A1 (ru)
ZA (1) ZA201405266B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013092984A1 (en) * 2011-12-21 2013-06-27 Quantum Genomics Combination of (3s,3s') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent
TW202207917A (zh) * 2020-05-06 2022-03-01 法商量子基因科技有限公司 包含腦胺肽酶抑制劑、利尿劑及全身性腎素－血管收縮素系統阻斷劑之醫藥組合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773712B1 (fr) * 1998-01-16 2000-06-02 Inst Nat Sante Rech Med Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a
WO2004007441A2 (fr) 2002-07-16 2004-01-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Derives de 4,4' -dithiobis- (3-aminobutane-1-sulfonates) nouveaux et compositions les contenant
FR2858617A1 (fr) * 2003-08-06 2005-02-11 Inst Nat Sante Rech Med Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant
US20080014187A1 (en) * 2006-07-15 2008-01-17 Bryant Villeponteau Compositions and Methods for Treating Hypertension and Inflammation
WO2013092984A1 (en) * 2011-12-21 2013-06-27 Quantum Genomics Combination of (3s,3s') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent

Also Published As

Publication number Publication date
EP2793878B1 (en) 2017-02-01
US20150320703A1 (en) 2015-11-12
HUE033403T2 (en) 2017-11-28
PL2793878T3 (pl) 2017-08-31
HRP20170267T1 (hr) 2017-05-19
RS55774B1 (sr) 2017-07-31
CN104220062A (zh) 2014-12-17
MX345469B (es) 2017-02-01
SI2793878T1 (sl) 2017-07-31
DK2793878T3 (en) 2017-03-27
CY1118711T1 (el) 2017-07-12
ES2619027T3 (es) 2017-06-22
LT2793878T (lt) 2017-05-25
AU2012356895A1 (en) 2014-07-31
US10959938B2 (en) 2021-03-30
WO2013092984A1 (en) 2013-06-27
MX2014007547A (es) 2014-08-01
BR112014015276B1 (pt) 2020-09-29
EA028718B1 (ru) 2017-12-29
AU2012356895B2 (en) 2017-05-25
ZA201405266B (en) 2016-06-29
JP2015506338A (ja) 2015-03-02
CA2859704C (en) 2020-04-28
CA2859704A1 (en) 2013-06-27
CN109464432A (zh) 2019-03-15
IL233156A0 (en) 2014-07-31
CN104220062B (zh) 2018-06-15
IL233156B (en) 2018-05-31
BR112014015276A8 (pt) 2017-06-13
EP2793878A1 (en) 2014-10-29
KR20140116879A (ko) 2014-10-06
JP6212500B2 (ja) 2017-10-11
PT2793878T (pt) 2017-03-23
JP2017222696A (ja) 2017-12-21
HK1203051A1 (en) 2015-10-16
IN2014DN05787A (ru) 2015-05-15
NZ627251A (en) 2015-08-28
JP6726138B2 (ja) 2020-07-22
BR112014015276A2 (pt) 2017-06-13

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