CY1118711T1 - Συνδυασμος ( 3s, 3s' )4, 4'-δισουλφανοδιυλοδι (3-αμινοβουτανο 1-σουλφονικου οξεος) και ενος δευτερου αντιυπερτασικου παραγοντα - Google Patents
Συνδυασμος ( 3s, 3s' )4, 4'-δισουλφανοδιυλοδι (3-αμινοβουτανο 1-σουλφονικου οξεος) και ενος δευτερου αντιυπερτασικου παραγονταInfo
- Publication number
- CY1118711T1 CY1118711T1 CY20171100303T CY171100303T CY1118711T1 CY 1118711 T1 CY1118711 T1 CY 1118711T1 CY 20171100303 T CY20171100303 T CY 20171100303T CY 171100303 T CY171100303 T CY 171100303T CY 1118711 T1 CY1118711 T1 CY 1118711T1
- Authority
- CY
- Cyprus
- Prior art keywords
- combination
- sulfonic acid
- hypertenic
- dissulfanodylylide
- aminobutano
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μία φαρμακευτική σύνθεση η οποία περιλαμβάνει, σε τουλάχιστον ένα φαρμακευτικά αποδεκτό υλικό στήριξης ή φορέα, ένα συνδυασμό από (3S, 3S') 4,4'-δισουλφανοδιυλοδι (3-αμινοβουτανο 1-σουλφονικό οξύ) ή ένα φαρμακευτικά αποδεκτό άλας αυτού ή μορφή αυτού με ενσωματωμένο διαλύτη στο πλέγμα της και ένα δεύτερο δραστικό συστατικό που επιλέγεται από την ομάδα που αποτελείται από αναστολείς του μετατρεπτικού ενζύμου της αγγειοτενσίνης I και ανταγωνιστές των υποδοχέων τύπου 1 της αγγειοτενσίνης II. Η εν λόγω σύνθεση είναι ιδιαίτερα χρήσιμη για τη θεραπεία της υπέρτασης και των σχετικών νόσων και καταστάσεων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306735 | 2011-12-21 | ||
| PCT/EP2012/076607 WO2013092984A1 (en) | 2011-12-21 | 2012-12-21 | Combination of (3s,3s') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent |
| EP12812987.1A EP2793878B1 (en) | 2011-12-21 | 2012-12-21 | Combination of (3s,3s') 4,4'-disulfanediylbis(3-aminobutane 1-sulfonic acid) and a second antihypertensive agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118711T1 true CY1118711T1 (el) | 2017-07-12 |
Family
ID=47522577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100303T CY1118711T1 (el) | 2011-12-21 | 2017-03-09 | Συνδυασμος ( 3s, 3s' )4, 4'-δισουλφανοδιυλοδι (3-αμινοβουτανο 1-σουλφονικου οξεος) και ενος δευτερου αντιυπερτασικου παραγοντα |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US10959938B2 (el) |
| EP (1) | EP2793878B1 (el) |
| JP (2) | JP6212500B2 (el) |
| KR (1) | KR20140116879A (el) |
| CN (2) | CN109464432A (el) |
| AU (1) | AU2012356895B2 (el) |
| BR (1) | BR112014015276B1 (el) |
| CA (1) | CA2859704C (el) |
| CY (1) | CY1118711T1 (el) |
| DK (1) | DK2793878T3 (el) |
| EA (1) | EA028718B1 (el) |
| ES (1) | ES2619027T3 (el) |
| HK (1) | HK1203051A1 (el) |
| HR (1) | HRP20170267T1 (el) |
| HU (1) | HUE033403T2 (el) |
| IL (1) | IL233156B (el) |
| IN (1) | IN2014DN05787A (el) |
| LT (1) | LT2793878T (el) |
| MX (1) | MX345469B (el) |
| PL (1) | PL2793878T3 (el) |
| PT (1) | PT2793878T (el) |
| RS (1) | RS55774B1 (el) |
| SI (1) | SI2793878T1 (el) |
| WO (1) | WO2013092984A1 (el) |
| ZA (1) | ZA201405266B (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX345469B (es) * | 2011-12-21 | 2017-02-01 | Quantum Genomics | Combinacion de (3s,3s') 4,4'-disulfandiilbis(acido 3-aminobutan 1-sulfonico) y un segundo agente antihipertensivo. |
| TW202207917A (zh) * | 2020-05-06 | 2022-03-01 | 法商量子基因科技有限公司 | 包含腦胺肽酶抑制劑、利尿劑及全身性腎素－血管收縮素系統阻斷劑之醫藥組合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773712B1 (fr) * | 1998-01-16 | 2000-06-02 | Inst Nat Sante Rech Med | Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a |
| ATE400552T1 (de) * | 2002-07-16 | 2008-07-15 | Inst Nat Sante Rech Med | 4,4' -dithiobis- (3-aminobutane-1-sulfonate)- derivate und sie enthaltende zusammensetzungen |
| FR2858617A1 (fr) * | 2003-08-06 | 2005-02-11 | Inst Nat Sante Rech Med | Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant |
| US20080014187A1 (en) * | 2006-07-15 | 2008-01-17 | Bryant Villeponteau | Compositions and Methods for Treating Hypertension and Inflammation |
| MX345469B (es) * | 2011-12-21 | 2017-02-01 | Quantum Genomics | Combinacion de (3s,3s') 4,4'-disulfandiilbis(acido 3-aminobutan 1-sulfonico) y un segundo agente antihipertensivo. |
-
2012
- 2012-12-21 MX MX2014007547A patent/MX345469B/es active IP Right Grant
- 2012-12-21 DK DK12812987.1T patent/DK2793878T3/en active
- 2012-12-21 HU HUE12812987A patent/HUE033403T2/en unknown
- 2012-12-21 JP JP2014548062A patent/JP6212500B2/ja active Active
- 2012-12-21 EA EA201400724A patent/EA028718B1/ru unknown
- 2012-12-21 US US14/367,408 patent/US10959938B2/en active Active
- 2012-12-21 PL PL12812987T patent/PL2793878T3/pl unknown
- 2012-12-21 AU AU2012356895A patent/AU2012356895B2/en active Active
- 2012-12-21 SI SI201230901A patent/SI2793878T1/sl unknown
- 2012-12-21 WO PCT/EP2012/076607 patent/WO2013092984A1/en active Application Filing
- 2012-12-21 CN CN201810509836.2A patent/CN109464432A/zh active Pending
- 2012-12-21 CN CN201280069935.4A patent/CN104220062B/zh not_active Expired - Fee Related
- 2012-12-21 CA CA2859704A patent/CA2859704C/en active Active
- 2012-12-21 ES ES12812987.1T patent/ES2619027T3/es active Active
- 2012-12-21 RS RS20170225A patent/RS55774B1/sr unknown
- 2012-12-21 BR BR112014015276-4A patent/BR112014015276B1/pt active IP Right Grant
- 2012-12-21 EP EP12812987.1A patent/EP2793878B1/en active Active
- 2012-12-21 IN IN5787DEN2014 patent/IN2014DN05787A/en unknown
- 2012-12-21 PT PT128129871T patent/PT2793878T/pt unknown
- 2012-12-21 LT LTEP12812987.1T patent/LT2793878T/lt unknown
- 2012-12-21 KR KR1020147020364A patent/KR20140116879A/ko active Search and Examination
-
2014
- 2014-06-16 IL IL233156A patent/IL233156B/en active IP Right Grant
- 2014-07-18 ZA ZA2014/05266A patent/ZA201405266B/en unknown
-
2015
- 2015-04-13 HK HK15103574.1A patent/HK1203051A1/xx not_active IP Right Cessation
-
2017
- 2017-02-20 HR HRP20170267TT patent/HRP20170267T1/hr unknown
- 2017-03-09 CY CY20171100303T patent/CY1118711T1/el unknown
- 2017-07-21 JP JP2017141918A patent/JP6726138B2/ja not_active Expired - Fee Related
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