CY1113594T1 - Φουμαρικο αλας της (αλφα s, βητα r)-6-βρωμο-αλφα-[2-(διμεθυλαμινο)αιθυλ]-2-μεθοξυ-αλφα-1-ναφθαλινυλ-βητα-φαινυλ-3-κινολινοαιθανολης - Google Patents
Φουμαρικο αλας της (αλφα s, βητα r)-6-βρωμο-αλφα-[2-(διμεθυλαμινο)αιθυλ]-2-μεθοξυ-αλφα-1-ναφθαλινυλ-βητα-φαινυλ-3-κινολινοαιθανοληςInfo
- Publication number
- CY1113594T1 CY1113594T1 CY20121100734T CY121100734T CY1113594T1 CY 1113594 T1 CY1113594 T1 CY 1113594T1 CY 20121100734 T CY20121100734 T CY 20121100734T CY 121100734 T CY121100734 T CY 121100734T CY 1113594 T1 CY1113594 T1 CY 1113594T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alpha
- beta
- phenyl
- methoxy
- ethyl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Abstract
Η παρούσα εφεύρεση αφορά το φουμαρικό άλας της (άλφα S, βήτα R)-6-βρωμο-άλφα-[2-(διμεθυλαμινο)αιθυλ]-2-μεθοξυ-άλφα-1-ναφθαλινυλ-βήτα-φαινυλ-3-κινολινοαιθανόλης, φαρμακευτικές συνθέσεις που περιλαμβάνουν ως δραστικό συστατικό το εν λόγω άλας και διεργασίες για την παρασκευή τους.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06125443 | 2006-12-05 | ||
EP07847697A EP2086940B1 (en) | 2006-12-05 | 2007-12-03 | Fumarate salt of (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113594T1 true CY1113594T1 (el) | 2016-06-22 |
Family
ID=37983588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100734T CY1113594T1 (el) | 2006-12-05 | 2012-08-13 | Φουμαρικο αλας της (αλφα s, βητα r)-6-βρωμο-αλφα-[2-(διμεθυλαμινο)αιθυλ]-2-μεθοξυ-αλφα-1-ναφθαλινυλ-βητα-φαινυλ-3-κινολινοαιθανολης |
Country Status (34)
Country | Link |
---|---|
US (1) | US8546428B2 (el) |
EP (1) | EP2086940B1 (el) |
JP (2) | JP2010511663A (el) |
KR (1) | KR101514700B1 (el) |
CN (2) | CN105012303A (el) |
AP (1) | AP2498A (el) |
AR (1) | AR064149A1 (el) |
AU (1) | AU2007328945B2 (el) |
BR (1) | BRPI0719693A2 (el) |
CA (1) | CA2668512C (el) |
CL (1) | CL2007003472A1 (el) |
CY (1) | CY1113594T1 (el) |
DK (1) | DK2086940T3 (el) |
EA (1) | EA017091B9 (el) |
ES (1) | ES2387923T3 (el) |
HK (1) | HK1214513A1 (el) |
HR (1) | HRP20120639T1 (el) |
IL (1) | IL199077A (el) |
JO (1) | JO2973B1 (el) |
ME (1) | ME01456B (el) |
MX (1) | MX2009005909A (el) |
MY (1) | MY148844A (el) |
NO (1) | NO342773B1 (el) |
NZ (1) | NZ576485A (el) |
PE (1) | PE20081350A1 (el) |
PL (1) | PL2086940T3 (el) |
PT (1) | PT2086940E (el) |
RS (1) | RS52408B (el) |
SI (1) | SI2086940T1 (el) |
TW (1) | TWI417098B (el) |
UA (1) | UA97813C2 (el) |
UY (1) | UY30762A1 (el) |
WO (1) | WO2008068231A1 (el) |
ZA (1) | ZA200903907B (el) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120010216A1 (en) * | 2010-07-06 | 2012-01-12 | Brown Arthur M | Pharmaceutical compositions containing vanoxerine |
CZ2014708A3 (cs) * | 2014-10-16 | 2016-04-27 | Zentiva, K.S. | Soli Bedaquilinu |
SG11201705944TA (en) * | 2015-01-27 | 2017-08-30 | Janssen Pharmaceutica Nv | Dispersible compositions |
CN106279017A (zh) * | 2015-05-21 | 2017-01-04 | 重庆圣华曦药业股份有限公司 | 贝达喹啉晶型、组合物及其制备方法 |
CZ2015391A3 (cs) * | 2015-06-09 | 2016-12-21 | Zentiva, K.S. | Sůl bedaquilinu s kyselinou citronovou |
RU2018111482A (ru) * | 2015-10-20 | 2019-11-21 | Чжэцзян Хисунь Фармасьютикал Ко., Лтд. | Кристаллические формы бедаквилин фумарата и способы их получения |
KR20230117248A (ko) * | 2016-07-20 | 2023-08-07 | 노파르티스 아게 | 아미노피리딘 유도체 및 이의 선택적 alk-2 억제제로서의용도 |
CN106316943A (zh) * | 2016-07-27 | 2017-01-11 | 重庆华邦制药有限公司 | 富马酸贝达喹啉晶型化合物的精制方法 |
KR20210113628A (ko) | 2019-01-09 | 2021-09-16 | 얀센 파마슈티카 엔.브이. | 비결핵성 마이코박테리아 질환의 치료에서의 조합물 |
WO2020161743A1 (en) * | 2019-02-08 | 2020-08-13 | Mylan Laboratories Limited | Process for the preparation of bedaquiline fumarate |
KR102303635B1 (ko) * | 2020-07-01 | 2021-09-17 | 동아에스티 주식회사 | (1r,2s)-1-(6-브로모-2-메톡시퀴놀린-3-일)-4-디메틸아미노-2-(1-나프틸)-1-페닐-부탄-2-올 및 이의 약제학적으로 허용 가능한 염의 제조방법 |
CN111888477B (zh) * | 2020-09-15 | 2023-03-07 | 北京福元医药股份有限公司 | 一种贝达喹啉药物制剂 |
TW202233168A (zh) | 2020-11-12 | 2022-09-01 | 比利時商健生藥品公司 | 治療非結核分枝桿菌疾病的藥物組分之組合 |
US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
WO2023232838A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Pharmaceutica Nv | Bedaquiline for use in the treatment of leprosy |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3237575A1 (de) * | 1982-10-09 | 1984-04-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue orale mopidamolformen |
GB8824392D0 (en) * | 1988-10-18 | 1988-11-23 | Ciba Geigy Ag | Dispersible formulation |
TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
US5965572A (en) | 1996-10-28 | 1999-10-12 | The United States Of America As Respresented By The Secretary Of The Army | Methods for treating antibiotic-resistant infections |
CA2219070C (en) * | 1996-10-30 | 2007-12-18 | Eli Lilly And Company | Methods of preventing breast cancer |
US6819464B2 (en) * | 2002-06-19 | 2004-11-16 | Seiko Epson Corporation | Optical modulator, optical device and projector |
MXPA05001052A (es) * | 2002-07-25 | 2005-04-08 | Janssen Pharmaceutica Nv | Derivados de quinolina y su uso como inhibidores micobacterianos. |
WO2004050068A1 (en) * | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
CN1976704B (zh) * | 2004-05-28 | 2012-12-05 | 詹森药业有限公司 | 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途 |
CA2577273C (en) * | 2004-09-02 | 2013-11-19 | Janssen Pharmaceutica N.V. | Fumarate of 4-((4-((4-(2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile |
KR101301573B1 (ko) * | 2004-12-24 | 2013-09-04 | 얀센 파마슈티카 엔.브이. | 잠재성 튜버큐로시스의 치료법 |
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2007
- 2007-03-12 UA UAA200904218A patent/UA97813C2/uk unknown
- 2007-12-02 JO JO2007511A patent/JO2973B1/en active
- 2007-12-03 CL CL200703472A patent/CL2007003472A1/es unknown
- 2007-12-03 WO PCT/EP2007/063186 patent/WO2008068231A1/en active Application Filing
- 2007-12-03 SI SI200730984T patent/SI2086940T1/sl unknown
- 2007-12-03 RS RS20120336A patent/RS52408B/en unknown
- 2007-12-03 MY MYPI20092284A patent/MY148844A/en unknown
- 2007-12-03 MX MX2009005909A patent/MX2009005909A/es active IP Right Grant
- 2007-12-03 NZ NZ576485A patent/NZ576485A/en unknown
- 2007-12-03 PL PL07847697T patent/PL2086940T3/pl unknown
- 2007-12-03 US US12/515,986 patent/US8546428B2/en active Active
- 2007-12-03 ES ES07847697T patent/ES2387923T3/es active Active
- 2007-12-03 JP JP2009539724A patent/JP2010511663A/ja active Pending
- 2007-12-03 CN CN201510368829.1A patent/CN105012303A/zh active Pending
- 2007-12-03 AP AP2009004870A patent/AP2498A/xx active
- 2007-12-03 AU AU2007328945A patent/AU2007328945B2/en active Active
- 2007-12-03 CN CNA2007800448088A patent/CN101547904A/zh active Pending
- 2007-12-03 EP EP07847697A patent/EP2086940B1/en active Active
- 2007-12-03 EA EA200970532A patent/EA017091B9/ru active Protection Beyond IP Right Term
- 2007-12-03 BR BRPI0719693-8A2A patent/BRPI0719693A2/pt not_active Application Discontinuation
- 2007-12-03 DK DK07847697.5T patent/DK2086940T3/da active
- 2007-12-03 ME MEP-2012-95A patent/ME01456B/me unknown
- 2007-12-03 KR KR1020097011043A patent/KR101514700B1/ko active IP Right Grant
- 2007-12-03 PT PT07847697T patent/PT2086940E/pt unknown
- 2007-12-03 CA CA2668512A patent/CA2668512C/en active Active
- 2007-12-04 TW TW096146000A patent/TWI417098B/zh active
- 2007-12-05 PE PE2007001719A patent/PE20081350A1/es active IP Right Grant
- 2007-12-05 AR ARP070105442A patent/AR064149A1/es not_active Application Discontinuation
- 2007-12-05 UY UY30762A patent/UY30762A1/es active IP Right Grant
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2009
- 2009-06-02 IL IL199077A patent/IL199077A/en active IP Right Grant
- 2009-06-04 ZA ZA2009/03907A patent/ZA200903907B/en unknown
- 2009-07-06 NO NO20092535A patent/NO342773B1/no unknown
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2012
- 2012-08-06 HR HRP20120639TT patent/HRP20120639T1/hr unknown
- 2012-08-13 CY CY20121100734T patent/CY1113594T1/el unknown
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2014
- 2014-09-19 JP JP2014191134A patent/JP5894239B2/ja active Active
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2016
- 2016-03-04 HK HK16102481.4A patent/HK1214513A1/zh unknown
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