CY1119252T1 - Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40 - Google Patents

Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40

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Publication number
CY1119252T1
CY1119252T1 CY20171100858T CY171100858T CY1119252T1 CY 1119252 T1 CY1119252 T1 CY 1119252T1 CY 20171100858 T CY20171100858 T CY 20171100858T CY 171100858 T CY171100858 T CY 171100858T CY 1119252 T1 CY1119252 T1 CY 1119252T1
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CY
Cyprus
Prior art keywords
cx3cr1
expression
hydroxymethylundazolis
benzylo
new products
Prior art date
Application number
CY20171100858T
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English (en)
Inventor
Angelo Guglielmotti
Guido Furlotti
Giorgina Mangano
Nicola Cazzolla
Barbara Garofalo
Original Assignee
Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A.
Publication of CY1119252T1 publication Critical patent/CY1119252T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέα παράγωγα της 1-βενζυλο-3-υδροξυμεθυλινδαζόλης σύμφωνα με τον Τύπο (I) που περιγράφεται στις αξιώσεις και σε μια φαρμακευτική σύνθεση που περιέχει αυτά, μαζί με ένα φαρμακευτικά αποδεκτό κυστίδιο. Επιπλέον, η παρούσα εφεύρεση σχετίζεται με τη χρήση παραγώγων της 1-βενζυλο-3-υδροξυμεθυλινδαζόλης για την παρασκευή μιας φαρμακευτικής σύνθεσης η οποία είναι δραστική στη θεραπεία νόσων που βασίζονται στην έκφραση των MCP-1, CX3CR1 και p40, και στη χρήση αυτών σε μια μέθοδο αντιμετώπισης ή πρόληψης νόσων που βασίζονται στην έκφραση των MCP-1, CX3CR1 και p40.
CY20171100858T 2008-03-07 2017-08-09 Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40 CY1119252T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08425139 2008-03-07
EP09717638.2A EP2254869B1 (en) 2008-03-07 2009-03-05 Neue 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of cx3cr1 und p40
PCT/EP2009/052585 WO2009109613A2 (en) 2008-03-07 2009-03-05 Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40

Publications (1)

Publication Number Publication Date
CY1119252T1 true CY1119252T1 (el) 2018-02-14

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ID=39671487

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100406T CY1117584T1 (el) 2008-03-07 2016-05-13 Παραγωγα 1-βενζυλ-3-υδροξυμεθυλινδαζολης και η χρηση τους στη θεραπευτικη αντιμετωπιση νοσων που βασιζονται στην εκφραση των mcp-1, cx3cr1
CY20171100858T CY1119252T1 (el) 2008-03-07 2017-08-09 Νεα παραγωγα 1-βενζυλο-3 -υδροξυμεθυλινδαζολης και χρηση αυτων στη θεραπεια νοσων που βασιζονται στην εκφραση των cx3cr1 και ρ40

Family Applications Before (1)

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CY20161100406T CY1117584T1 (el) 2008-03-07 2016-05-13 Παραγωγα 1-βενζυλ-3-υδροξυμεθυλινδαζολης και η χρηση τους στη θεραπευτικη αντιμετωπιση νοσων που βασιζονται στην εκφραση των mcp-1, cx3cr1

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US (3) US7919518B2 (el)
EP (3) EP3181551A1 (el)
JP (2) JP5509099B2 (el)
KR (2) KR101581828B1 (el)
CN (2) CN101945855B (el)
AR (2) AR070810A1 (el)
AU (2) AU2009221083B2 (el)
BR (2) BRPI0907977A2 (el)
CA (2) CA2712703C (el)
CY (2) CY1117584T1 (el)
DK (2) DK2254869T3 (el)
EA (2) EA018241B1 (el)
ES (2) ES2569330T3 (el)
GE (2) GEP20135983B (el)
HR (2) HRP20160462T1 (el)
HU (1) HUE027098T2 (el)
IL (3) IL206893A0 (el)
LT (1) LT2254869T (el)
MX (2) MX2010009623A (el)
PL (2) PL2254869T3 (el)
PT (1) PT2254869T (el)
SG (1) SG188177A1 (el)
SI (2) SI2254869T1 (el)
UA (2) UA103605C2 (el)
WO (2) WO2009109613A2 (el)

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GEP20135912B (en) 2013-08-26
EP3181551A1 (en) 2017-06-21
BRPI0907977A2 (pt) 2015-08-04
SI2254870T1 (sl) 2016-05-31
JP5509099B2 (ja) 2014-06-04
EP2254870A2 (en) 2010-12-01
UA105170C2 (en) 2014-04-25
ES2569330T3 (es) 2016-05-10
CN101945855B (zh) 2014-12-17
IL207131A0 (en) 2010-12-30
AU2009221089A1 (en) 2009-09-11
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