CY1122610T1 - Αλκοξυ πυραζολια ως ενεργοποιητες διαλυτης γουανυλικης κυκλασης - Google Patents

Αλκοξυ πυραζολια ως ενεργοποιητες διαλυτης γουανυλικης κυκλασης

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Publication number
CY1122610T1
CY1122610T1 CY20191101099T CY191101099T CY1122610T1 CY 1122610 T1 CY1122610 T1 CY 1122610T1 CY 20191101099 T CY20191101099 T CY 20191101099T CY 191101099 T CY191101099 T CY 191101099T CY 1122610 T1 CY1122610 T1 CY 1122610T1
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CY
Cyprus
Prior art keywords
wanylate
cycles
compounds
solvent activators
pyrazoles
Prior art date
Application number
CY20191101099T
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English (en)
Inventor
Jehrod Burnett BRENNEMAN
John David Ginn
Michael D. Lowe
Christopher Ronald Sarko
Edward S. Tasber
Zhonghua Zhang
Original Assignee
Boehringer Ingelheim International Gmbh
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Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of CY1122610T1 publication Critical patent/CY1122610T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61P17/06—Antipsoriatics
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
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  • Pain & Pain Management (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
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  • Gastroenterology & Hepatology (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε ενώσεις του τύπου (I): και φαρμακευτικώς αποδεκτά άλατα αυτών, όπου R1, R2, R3, R4, R5, R6 και R7 είναι όπως ορίζεται στο παρόν. Η εφεύρεση επίσης αφορά σε φαρμακευτικές συνθέσεις που περιλαμβάνουν αυτές τις ενώσεις, μεθόδους χρήσης αυτών των ενώσεων στη θεραπεία διαφόρων ασθενειών και διαταραχών, διεργασίες για παρασκευή αυτών των ενώσεων και ενδιάμεσα χρήσιμα σε αυτές τις διεργασίες.
CY20191101099T 2012-09-07 2019-10-22 Αλκοξυ πυραζολια ως ενεργοποιητες διαλυτης γουανυλικης κυκλασης CY1122610T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261697899P 2012-09-07 2012-09-07
PCT/US2013/057826 WO2014039434A1 (en) 2012-09-07 2013-09-03 Alkoxy pyrazoles as soluble guanylate cyclase activators

Publications (1)

Publication Number Publication Date
CY1122610T1 true CY1122610T1 (el) 2021-03-12

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US (2) US8906904B2 (el)
EP (1) EP2892891B1 (el)
JP (1) JP5970134B2 (el)
KR (1) KR101692707B1 (el)
CN (1) CN104619695B (el)
AP (1) AP2015008231A0 (el)
AR (1) AR092869A1 (el)
AU (1) AU2013312931B2 (el)
BR (1) BR112015004529B1 (el)
CA (1) CA2880494C (el)
CL (2) CL2015000255A1 (el)
CY (1) CY1122610T1 (el)
DK (1) DK2892891T3 (el)
EA (1) EA027244B1 (el)
EC (1) ECSP15012804A (el)
ES (1) ES2748798T3 (el)
GE (1) GEP20176631B (el)
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PE (1) PE20151001A1 (el)
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PL (1) PL2892891T3 (el)
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20176631B (en) * 2012-09-07 2017-02-27 Boehringer Ingelheim Int Alkoxy pyrazoles as soluble guanylate cyclase activators
TW201625584A (zh) 2014-07-02 2016-07-16 諾華公司 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
ES2784477T3 (es) 2014-07-22 2020-09-28 Boehringer Ingelheim Int Acidos carboxílicos heterocíclicos como activadores de guanilato ciclasa soluble
WO2017103888A1 (en) 2015-12-18 2017-06-22 Novartis Ag Indane derivatives and the use thereof as soluble guanylate cyclase activators
WO2018069148A1 (de) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
WO2019211081A1 (en) 2018-04-30 2019-11-07 Bayer Aktiengesellschaft The use of sgc activators and sgc stimulators for the treatment of cognitive impairment
TW202015676A (zh) 2018-05-15 2020-05-01 德商拜耳廠股份有限公司 經1,3-噻唑-2-基取代之苯甲醯胺用於治療與神經纖維敏化作用相關疾病之用途
US11508483B2 (en) 2018-05-30 2022-11-22 Adverio Pharma Gmbh Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group
EP3820470A1 (en) * 2018-07-12 2021-05-19 Boehringer Ingelheim International GmbH Alkoxy pyrazoles as soluble guanylate cyclase activators
EP3911675A1 (en) 2019-01-17 2021-11-24 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
CN112079712B (zh) * 2020-09-18 2022-12-13 江苏美迪克化学品有限公司 一种对乙烯基水杨酸的制备方法
GB202102895D0 (en) 2021-03-01 2021-04-14 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof
TW202402274A (zh) 2022-03-21 2024-01-16 德商百靈佳殷格翰國際股份有限公司 用於治療門脈高壓之可溶性鳥苷酸環化酶活化劑
WO2023237577A1 (en) 2022-06-09 2023-12-14 Bayer Aktiengesellschaft Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9824310D0 (en) * 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
AU2002214626A1 (en) 2000-09-29 2002-04-08 Cor Therapeutics, Inc. Quaternary amines and related inhibitors of factor xa
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
CA2428989A1 (en) 2000-11-22 2002-05-30 Visx Incorporated Temperature actuated positioning device for non-linear optical elements
GB0212785D0 (en) * 2002-05-31 2002-07-10 Glaxo Group Ltd Compounds
EP1572693A1 (en) 2002-12-20 2005-09-14 Pharmacia Corporation Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds
CA2615426A1 (en) 2005-07-18 2007-01-25 Bayer Healthcare Ag Novel use of activators and stimulators of soluble guanylate cyclase for the prevention or treatment of renal disorders
US20080045560A1 (en) 2006-08-15 2008-02-21 Wyeth Pyrrolidine and related derivatives useful as PR modulators
US20100210643A1 (en) 2007-05-12 2010-08-19 Bayer Schering Pharma Aktiengesellschaft sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS
WO2009032249A1 (en) 2007-09-06 2009-03-12 Merck & Co., Inc. Soluble guanylate cyclase activators
MX2010003071A (es) * 2007-10-05 2010-04-01 Sanofi Aventis Deutschland Uso de n-fenilamidas de acido 2-sulfonilaminobenzoico sustituidas con sulfonilo en el tratamiento del dolor.
WO2009068652A1 (en) 2007-11-30 2009-06-04 Smithkline Beecham Corporation 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines as soluble guanylate cyclase activators
TW200938529A (en) * 2007-12-03 2009-09-16 Smithkline Beecham Corp Compounds
JP5432890B2 (ja) * 2008-04-04 2014-03-05 武田薬品工業株式会社 複素環誘導体及びその用途
WO2010015653A1 (en) 2008-08-07 2010-02-11 Smithkline Beecham Corporation Pyrimidine derivatives as activators of soluble guanylate cyclase
WO2010015652A2 (en) * 2008-08-07 2010-02-11 Smithkline Beecham Corporation Thiazole compounds as activators of soluble guanylate cyclase
AU2009322836B2 (en) 2008-11-25 2013-04-04 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
JP5780430B2 (ja) 2009-01-17 2015-09-16 アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 勃起不全の処置用のＰＤＥ５阻害剤と組み合わせたｓＧＣ刺激剤またはｓＧＣ活性化剤
JP5411300B2 (ja) 2009-02-26 2014-02-12 メルク・シャープ・アンド・ドーム・コーポレーション 可溶性グアニレートシクラーゼ活性化剤
ES2548394T3 (es) * 2010-02-05 2015-10-16 Adverio Pharma Gmbh Estimuladores de la GCs o activadores de la GCs solos y en combinación con inhibidores de la PDE5 para el tratamiento de la fibrosis quística
WO2011095553A1 (en) 2010-02-05 2011-08-11 Bayer Schering Pharma Aktiengesellschaft Sgc stimulators or sgc activators in combination with pde5 inhbitors for the treatment of erectile dysfunction
ME02207B (me) * 2010-05-26 2016-02-20 Adverio Pharma Gmbh UPOTREBA sGC STIMULATORA, sGC AKTIVATORA, POJEDINAČNO I U KOMBINACIJI SA PDE5 INHIBITORIMA ZA TRETMAN SISTEMSKE SKLEROZE (SSc)
US20130158028A1 (en) 2010-06-25 2013-06-20 Bayer Intellectual Property Gmbh Use of stimulators and activators of soluble guanylate cyclase for treating sickle-cell anemia and conserving blood substitutes
US8895583B2 (en) 2010-10-28 2014-11-25 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
US8569339B2 (en) 2011-03-10 2013-10-29 Boehringer Ingelheim International Gmbh Soluble guanylate cyclase activators
WO2013025425A1 (en) 2011-08-12 2013-02-21 Boehringer Ingelheim International Gmbh Soluble guanylate cyclase activators
EP2594270A3 (en) 2011-11-18 2013-07-31 BIP Patents The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc)
GEP20176631B (en) * 2012-09-07 2017-02-27 Boehringer Ingelheim Int Alkoxy pyrazoles as soluble guanylate cyclase activators

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MA37891B1 (fr) 2018-05-31
CL2015000562A1 (es) 2015-06-12
UA115881C2 (uk) 2018-01-10
EA201500298A1 (ru) 2015-08-31
PH12015500457B1 (en) 2015-04-20
TN2015000054A1 (en) 2016-06-29
PE20151001A1 (es) 2015-07-15
SG11201500861QA (en) 2015-04-29
MD4425C1 (ro) 2017-01-31
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