MD4425B1 - Alcoxipirazoli în calitate de activatori ai guanilatciclazei solubile - Google Patents
Alcoxipirazoli în calitate de activatori ai guanilatciclazei solubile Download PDFInfo
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- MD4425B1 MD4425B1 MDA20150019A MD20150019A MD4425B1 MD 4425 B1 MD4425 B1 MD 4425B1 MD A20150019 A MDA20150019 A MD A20150019A MD 20150019 A MD20150019 A MD 20150019A MD 4425 B1 MD4425 B1 MD 4425B1
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- guanylate cyclase
- 6alkyl
- ome
- compounds
- soluble guanylate
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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Abstract
Prezenta invenţie se referă la compuşi cu formula (I):(I)şi sărurile acceptabile farmaceutic ale acestora, unde A este o grupare heterociclil saturată cu 5...7 membri, conţinând un atom de azot şi opţional un atom de oxigen; R1 este un alchil-C1-4 substituit opţional cu o grupare metoxi; R2 este selectat dintre H, F, Cl, alchil-C1-3, -CN, -OMe şi -CF3; R3 este selectat dintre H şi -CH3; R4 este selectat dintre H, F, -CH3 şi -OMe; R5 este selectat dintre H, Cl, -CH3, -CH2CH3, -CF3, F şi -OMe; R6 este legat de azotul din gruparea A şi este selectat dintre H, alchil-C1-6, -(CH2)n-cicloalchil-C3-6, -C(O)-alchil-C1-6, -(CH2)n-heterociclil, -(CH2)n-aril-(CH2)n-heteroaril, -SO2-aril, SO2-alchil-C1-6; R7 este selectat dintre H, -CH3, -CH2CH3, -CF3, F şi -CN.Invenţia se referă, de asemenea, la compoziţii farmaceutice, care cuprind aceşti compuşi, la metode de utilizare a acestora în tratamentul diverselor boli şi tulburări, care pot fi atenuate prin activarea sau potenţarea guanilatciclazei solubile.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697899P | 2012-09-07 | 2012-09-07 | |
| PCT/US2013/057826 WO2014039434A1 (en) | 2012-09-07 | 2013-09-03 | Alkoxy pyrazoles as soluble guanylate cyclase activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20150019A2 MD20150019A2 (ro) | 2015-07-31 |
| MD4425B1 true MD4425B1 (ro) | 2016-06-30 |
| MD4425C1 MD4425C1 (ro) | 2017-01-31 |
Family
ID=49170904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20150019A MD4425C1 (ro) | 2012-09-07 | 2013-09-03 | Alcoxipirazoli în calitate de activatori ai guanilat-ciclazei solubile |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US8906904B2 (ro) |
| EP (1) | EP2892891B1 (ro) |
| JP (1) | JP5970134B2 (ro) |
| KR (1) | KR101692707B1 (ro) |
| CN (1) | CN104619695B (ro) |
| AP (1) | AP2015008231A0 (ro) |
| AR (1) | AR092869A1 (ro) |
| AU (1) | AU2013312931B2 (ro) |
| BR (1) | BR112015004529B1 (ro) |
| CA (1) | CA2880494C (ro) |
| CL (2) | CL2015000255A1 (ro) |
| CY (1) | CY1122610T1 (ro) |
| DK (1) | DK2892891T3 (ro) |
| EA (1) | EA027244B1 (ro) |
| EC (1) | ECSP15012804A (ro) |
| ES (1) | ES2748798T3 (ro) |
| GE (1) | GEP20176631B (ro) |
| HR (1) | HRP20191755T1 (ro) |
| HU (1) | HUE046996T2 (ro) |
| IL (1) | IL236987A (ro) |
| LT (1) | LT2892891T (ro) |
| MA (1) | MA37891B1 (ro) |
| MD (1) | MD4425C1 (ro) |
| MX (1) | MX338887B (ro) |
| NZ (1) | NZ703989A (ro) |
| PE (1) | PE20151001A1 (ro) |
| PH (1) | PH12015500457B1 (ro) |
| PL (1) | PL2892891T3 (ro) |
| PT (1) | PT2892891T (ro) |
| RS (1) | RS59394B1 (ro) |
| SG (2) | SG11201500861QA (ro) |
| SI (1) | SI2892891T1 (ro) |
| TN (1) | TN2015000054A1 (ro) |
| TW (1) | TWI586661B (ro) |
| UA (1) | UA115881C2 (ro) |
| UY (1) | UY35012A (ro) |
| WO (1) | WO2014039434A1 (ro) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ703989A (en) * | 2012-09-07 | 2017-04-28 | Boehringer Ingelheim Int | Alkoxy pyrazoles as soluble guanylate cyclase activators |
| TW201625584A (zh) | 2014-07-02 | 2016-07-16 | 諾華公司 | 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途 |
| WO2016014463A1 (en) | 2014-07-22 | 2016-01-28 | Boehringer Ingelheim International Gmbh | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase |
| WO2017103888A1 (en) | 2015-12-18 | 2017-06-22 | Novartis Ag | Indane derivatives and the use thereof as soluble guanylate cyclase activators |
| WO2018069148A1 (de) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| CN112055584A (zh) | 2018-04-30 | 2020-12-08 | 拜耳公司 | sGC活化剂和sGC刺激剂用于治疗认知障碍的用途 |
| JP2021523201A (ja) | 2018-05-15 | 2021-09-02 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 神経線維感作に関連する疾患を治療するための１，３−チアゾール−２−イル置換ベンズアミド |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| EA202190193A1 (ru) * | 2018-07-12 | 2021-06-16 | Бёрингер Ингельхайм Интернациональ Гмбх | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| EP3976591B1 (en) * | 2019-10-18 | 2023-04-19 | FMC Corporation | Methods for the preparation of 5-bromo-2-(3-chloro-pyridin-2-yl)-2h-pyrazole-3-carboxylic acid |
| CN112079712B (zh) * | 2020-09-18 | 2022-12-13 | 江苏美迪克化学品有限公司 | 一种对乙烯基水杨酸的制备方法 |
| EP4011873A1 (en) | 2020-12-10 | 2022-06-15 | Bayer Aktiengesellschaft | Substituted pyrazolo piperidine carboxylic acids |
| ES2997117T3 (en) * | 2020-12-10 | 2025-02-14 | Bayer Ag | Substituted pyrazolo piperidine carboxylic acids |
| GB202102895D0 (en) | 2021-03-01 | 2021-04-14 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| CN118900690A (zh) | 2022-03-21 | 2024-11-05 | 勃林格殷格翰国际有限公司 | 用于治疗门脉高压的可溶性鸟苷酸环化酶活化剂 |
| CA3258617A1 (en) | 2022-06-09 | 2023-12-14 | Bayer Aktiengesellschaft | SOLUBLE GUANYLATE CYCLASE ACTIVATORS FOR USE IN THE TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN WOMEN |
| WO2024097316A1 (en) | 2022-11-04 | 2024-05-10 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators for treating systemic sclerosis |
| WO2024123847A1 (en) | 2022-12-09 | 2024-06-13 | Boehringer Ingelheim International Gmbh | Solid forms of a sgc activator |
| CN121620369A (zh) | 2023-08-16 | 2026-03-06 | 勃林格殷格翰国际有限公司 | 用于治疗临床显著门静脉高压和失代偿期肝硬化的可溶性鸟苷酸环化酶激活剂 |
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| BRPI1006869A2 (pt) * | 2009-01-17 | 2016-03-15 | Bayer Schering Pharma Ag | estimuladores de sgc ou ativadores da sgc em combinação com inibidores da pde5 para o tratamento de disfunção erétil |
| CN102414194A (zh) | 2009-02-26 | 2012-04-11 | 默沙东公司 | 可溶性鸟苷酸环化酶激活剂 |
| WO2011095553A1 (en) | 2010-02-05 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft | Sgc stimulators or sgc activators in combination with pde5 inhbitors for the treatment of erectile dysfunction |
| KR101793304B1 (ko) * | 2010-02-05 | 2017-11-02 | 아드베리오 파마 게엠베하 | 낭성 섬유증의 치료를 위한, 단독으로의 및 ＰＤＥ5 억제제와 조합된 ｓＧＣ 자극제 또는 ｓＧＣ 활성화제 |
| CN103038232B (zh) * | 2010-05-26 | 2016-01-20 | 阿德弗里奥药品有限责任公司 | 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 |
| EP2585055A1 (de) | 2010-06-25 | 2013-05-01 | Bayer Intellectual Property GmbH | Verwendung von stimulatoren und aktivatoren der löslichen guanylatzyklase zur behandlung von sichelzellanämie und konservierung von blutersatzstoffen |
| EP2632551B1 (en) | 2010-10-28 | 2016-07-06 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| JP5715713B2 (ja) | 2011-03-10 | 2015-05-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性グアニル酸シクラーゼ活性化因子 |
| US8815857B2 (en) | 2011-08-12 | 2014-08-26 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators |
| EP2594270A3 (en) | 2011-11-18 | 2013-07-31 | BIP Patents | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) |
| NZ703989A (en) * | 2012-09-07 | 2017-04-28 | Boehringer Ingelheim Int | Alkoxy pyrazoles as soluble guanylate cyclase activators |
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