CN103038232B - 单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 - Google Patents
单独的和与PDE5抑制剂相组合的sGC刺激剂、sGC活化剂用于治疗系统性硬化症(SSc)的用途 Download PDFInfo
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- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Description
a)博来霉素 + 媒介物 | b)博来霉素 + 1 mg/kg实施例27 | c)博来霉素 + 3mg/kg实施例27 | ||
真皮厚度 | 1.70 | 1.37 | 1.19 | |
胶原含量 | 1.31 | 1.19 | 1.11 | |
肌成纤维细胞计数 | 3.72 | 3.23 | 1.90 |
a)博来霉素 + 媒介物 | b)博来霉素 + 1.0 mg/kg 实施例3 | c)博来霉素 + 0.3 mg/kg 实施例6 | d)博来霉素 + 1 mg/kg 实施例6 | e)博来霉素 + 3 mg/kg 实施例6 | |
真皮厚度 | 1.71 | 1.38 | 1.41 | 1.24 | 1.19 |
胶原含量 | 1.56 | 1.38 | 1.41 | 1.28 | 1.20 |
肌成纤维细胞计数 | 3.86 | 2.55 | 3.13 | 2.05 | 1.49 |
b)博来霉素 6周 | c)博来霉素6周 + 3周实施例27 | d)博来霉素3周 + 3周NaCl | ||
真皮厚度 | 1.57 | 1.26 | 1.40 | |
肌成纤维细胞计数 | 3.87 | 1.68 | 3.50 |
Tsk-1 + 媒介物 | Tsk-1 + 1 mg/kg实施例27 | Tsk-1 + 3mg/kg实施例27 | ||
真皮厚度 | 5.03 | 3.46 | 2.88 | |
胶原含量 | 2.46 | 1.61 | 1.67 | |
肌成纤维细胞计数 | 2.64 | 2.12 | 1.70 |
Claims (9)
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DE102010021637A DE102010021637A1 (de) | 2010-05-26 | 2010-05-26 | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
DE102010021637.2 | 2010-05-26 | ||
EP10170413 | 2010-07-22 | ||
EP10170413.8 | 2010-07-22 | ||
PCT/EP2011/058433 WO2011147810A1 (en) | 2010-05-26 | 2011-05-24 | THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc). |
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DE102010021637A1 (de) * | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
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