ME02207B - UPOTREBA sGC STIMULATORA, sGC AKTIVATORA, POJEDINAČNO I U KOMBINACIJI SA PDE5 INHIBITORIMA ZA TRETMAN SISTEMSKE SKLEROZE (SSc) - Google Patents

UPOTREBA sGC STIMULATORA, sGC AKTIVATORA, POJEDINAČNO I U KOMBINACIJI SA PDE5 INHIBITORIMA ZA TRETMAN SISTEMSKE SKLEROZE (SSc)

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Publication number
ME02207B
ME02207B MEP-2015-147A MEP14715A ME02207B ME 02207 B ME02207 B ME 02207B ME P14715 A MEP14715 A ME P14715A ME 02207 B ME02207 B ME 02207B
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ME
Montenegro
Prior art keywords
systemic sclerosis
prevention
treatment
ssc
fact
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Application number
MEP-2015-147A
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English (en)
Inventor
Claudia Hirth-Dietrich
Peter Sandner
Johannes-Peter Stasch
Andreas Knorr
Degenfeld Georges Von
Michael Hahn
Markus Follmann
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Adverio Pharma Gmbh
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Priority claimed from DE102010021637A external-priority patent/DE102010021637A1/de
Application filed by Adverio Pharma Gmbh filed Critical Adverio Pharma Gmbh
Publication of ME02207B publication Critical patent/ME02207B/me

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Description

SEKVENCA
[0096]
<110> Bayer Intellectual Property GmbH
<120> UPOTREBA sGC STIMULATORA, sGC AKTIVATORA, POJEDINAČNO I U KOMBINACIJI SA PDE5 INHIBITORIMA ZA TRETMAN SISTEMSKE SKLEROZE (SSc)
<130> BHC 10 1 013
<140> EP11722786.8
< 141> 2011-05-24
<160> 2
<170> PatentIn version 3.5
<210> 1
< 211> 20
< 212> DNA
< 213> Miš
<400> 1
gttggcaact atacctgcat   20
<210> 2
< 211> 20
< 212> DNA
< 213> Miš
<400> 2
cctttcctgg taacatagga   20
 
 

Claims (18)

1.Jedinjenja u skladu sa formulama (1) do (27),naznačena time, što se koriste za prevenciju i/ili tretman sistemske skleroze (SSc).
2.Jedinjenja u skladu sa formulama (1), (2), (3), (4), (5), (6), (7) i (27), naznačena time, što se koriste za prevenciju i/ili tretman sistemske skleroze (SSc).
3.Jedinjenje u skladu sa formulom (3), naznačeno time, što se koristi za prevenciju i/ili tretman sistemske skleroze.
4.Najmanje jedno jedinjenje u skladu sa zahtevima 1 do 3, naznačeno time, što se kombinuje sa najmanje jednim PDE5 inhibitorom koji je izabran iz sledeće grupe: Tadalafil ((6R,12aR)-2,3,6,7,12,12a-heksahidro-2-metil-6-(3,4-metilen-dioksifenil) pirazino(1',2':1,6)pirido(3,4-b)indol-1,4-dion), Vardenafil (2-(2-etoksi-5-(4-etilpiperazin-1-il-1-sulfonil)fenil)-5-metil-7-propil-3H-imidazo(5,1-f) (1,2,4)triazin-4-on), Sildenafil (3-[2-etoksi-5-(4-metilpiperazin-1-il)sulfonil-fenil]-7-metil-9- propi 1-2,4,7,8-tetrazabiciklo[4.3.0]nona-3,8,10-trien-5-on), Udenafil 5-[2-propiloksi-5-(1-metil-2-pirolidiniltilamidosulfonil)fenil]-metil-3-propil-1,6-dihidro-7H-pirazolo(4,3-d)pirimidin-7-on, Dasantafil 7-(3-bromo-4-metoksibenzil)-1-etil-8-[[(1,2)-2-hidroksiciklopentil]amino]-3-(2-hidroksietil)-3,7-dihidro-1-purin-2,6-dion, Avanafil 4-{[(3-hloro-4-metoksifenil)metil]amino}-2-[(2S)-2-(hidroksimetil)pirolidin-1-il]-N-(pirimidin-2-ilmetil)pirimidin-5-karboksamid, Mirodenafil, Lodenafil, dokumenti UK 369.003, UK 371.800, SLx 2101 od Surface Logix, LAS 34179triazolo[1,2-]ksantin,6-metil-4-propil-2-[2-propoksi-5-(4-metilpiperazino)sulfonil]fenil ili soli, hidrati ili hidrati pomenutih soli za upotrebu u prevenciji i/ili tretmanu sistemske skleroze (SSc).
5.Najmanje jedno jedinjenje u skladu sa zahtevima od 1 do 3, naznačeno time, što se kombinuje sa sildenafilom ili vardenafilom za upotrebu u prevenciji i/ili tretmanu sistemske skleroze (SSc).
6.Jedinjenja u skladu sa zahtevima od 1 do 5, naznačena time, što se koriste za prevenciju i/ili tretman sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (lSSc), sistemske skleroze preklopnog tipa, sistemske skleroze nediferenciranog tipa, sistemske skleroze sine skleroderma, kožne fibroze, skleroderme, nefrogene fibrozne dermopatije (NFD), nefrogene sistemske fibroze (NSF), nastanka keloida.
7.Jedinjenja u skladu sa zahtevima od 1 do 5, naznačena time, što se upotrebljavaju u prevenciji i/ili tretmanu sistemske skleroze SSc koja je praćena fibrozom unutarnjih organa, šta obuhvata creva, pluća, bubrege i krvne žile.
8.Jedinjenja u skladu sa formulama (3), (4), (6), i/ili (7), naznačena time, što se upotrebljavaju za prevenciju i/ili tretman sistemske skleroze SSc.
9.Najmanje jedno jedinjenje u skladu sa formulama (3), (4), (6) i/ili (7), naznačeno time, što se kombinuje sa vardenafilom ili sildenafilom za upotrebu u prevenciji i/ili tretmanu sistemske skleroze SSc.
10.Upotreba jedinjenja u skladu sa zahtevima od 1-9, naznačena time, što se pomenuta koriste za proizvodnju leka za prevenciju i/ili tretman sistemske skleroze (SSc) šta podrazumeva upotrebu efektivne količine nekog jedinjenja u skladu sa zahtevima od 1 do 9.
11.Upotreba jedinjenja u skladu sa zahtevima od 1-9, naznačena time, što se pomenuta upotrebljavaju za proizvodnju leka za prevenciju i/ili tretman sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (ISSc), sistemske skleroze preklopnog tipa, sistemske skleroze nediferenciranog tipa, sistemske skleroze sine skleroderma, kožne fibroze, skleroderme, nefrogene fibrozne dermopatije (NFD), nastanka keloida šta obuhvata upotrebu efektivne količine jedinjenja u skladu sa zahtevima od 1 do 9.
12.Upotreba jedinjenja u skladu sa zahtevima od 1-9, naznačena time, što se pomenuti upotrebljavaju u proizvodnji leka za prevenciju i/ili tretman sistemske skleroze SSc koja je praćena fibrozom unutarnjih organa, šta obuhvata creva, pluća, bubrege i krvne žile i podrazumeva upotrebu efektivne količine nekog jedinjenja u skladu sa zahtevima od 1 do 9.
13.Farmaceutska formulacija, naznačena time, što sadrži najmanje jedno jedinjenje ili jednu kombinaciju u skladu sa zahtevima od 1 do 9 za upotrebu u prevenciji i/ili tretmanu sistemske skleroze (SSc).
14.Farmaceutska formulacija, naznačena time, što sadrži najmanje jedno jedinjenje ili jednu kombinaciju u skladu sa zahtevima od 1 do 9 za upotrebu u prevenciji i/ili tretmanu sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (ISSc), sistemske skleroze preklopnog tipa, sistemske skleroze nediferenciranog tipa, sistemske skleroze sine skleroderma, kožne fibroze, skleroderme, nefrogene fibrozne dermopatije (NFD), nastanka keloida.
15.Farmaceutska formulacija, naznačena time, što sadrži najmanje jedno jedinjenje ili jednu kombinaciju u skladu sa zahtevima od 1 do 9 za upotrebu u prevenciji i/ili tretmanu sistemske skleroze SSc koja je praćena fibrozom unutarnjih organa, šta obuhvata creva, pluća, bubrege i krvne žile.
16.Komplet hemikalija, naznačen time, što sadrži najmanje jedan sGC stimulator i/ili aktivator u skladu sa zahtevima od 1 do 3 ili jednu kombinaciju u skladu sa zahtevima od 4 do 5 za upotrebu u prevenciji i/ili tretmanu sistemske skleroze (SSc).
17.Komplet hemikalija u skladu sa zahtevom 16, naznačen time, što se koristi za prevenciju i/ili tretman sistemske skleroze (SSc), difuzne sistemske skleroze (dSSc), ograničene sistemske skleroze (lSSc), sistemske skleroze preklopnog tipa, sistemske skleroze nediferenciranog tipa, sistemske skleroze sine skleroderma, kožne fibroze, skleroderme, nefrogene fibrozne dermopatije (NFD), nastanka keloida.
18.Komplet hemikalija u skladu sa zahtevima 16 i 17, naznačen time, što se upotrebljava za prevenciju i/ili tretman sistemske skleroze SSc koja je praćena fibrozom unutarnjih organa, šta obuhvata creva, pluća, bubrege i krvne žile.
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