TN2013000394A1 - Derives de pyrrolo [2,3-d] pyrimidine servant d'inhibiteurs de kinases apparentees a la tropomyosine - Google Patents
Derives de pyrrolo [2,3-d] pyrimidine servant d'inhibiteurs de kinases apparentees a la tropomyosineInfo
- Publication number
- TN2013000394A1 TN2013000394A1 TNP2013000394A TN2013000394A TN2013000394A1 TN 2013000394 A1 TN2013000394 A1 TN 2013000394A1 TN P2013000394 A TNP2013000394 A TN P2013000394A TN 2013000394 A TN2013000394 A TN 2013000394A TN 2013000394 A1 TN2013000394 A1 TN 2013000394A1
- Authority
- TN
- Tunisia
- Prior art keywords
- tropomyosin
- pyrrolo
- inhibitors
- pyrimidine derivatives
- related kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables, dans lesquels les substituants répondent aux descriptions figurant dans le présent mémoire, et leur utilisation en médicine, en particulier comme antagonistes de TrK.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161471758P | 2011-04-05 | 2011-04-05 | |
PCT/IB2012/051363 WO2012137089A1 (fr) | 2011-04-05 | 2012-03-22 | Dérivés de pyrrolo-[2,3-d]pyrimidine en tant qu'inhibiteurs des kinases associées à la tropomyosine |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2013000394A1 true TN2013000394A1 (fr) | 2015-01-20 |
Family
ID=45937493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2013000394A TN2013000394A1 (fr) | 2011-04-05 | 2013-09-27 | Derives de pyrrolo [2,3-d] pyrimidine servant d'inhibiteurs de kinases apparentees a la tropomyosine |
Country Status (31)
Country | Link |
---|---|
US (2) | US8846698B2 (fr) |
EP (1) | EP2694509B1 (fr) |
JP (1) | JP5595616B2 (fr) |
KR (1) | KR20130133905A (fr) |
CN (1) | CN103534257A (fr) |
AP (1) | AP2013007159A0 (fr) |
AR (1) | AR085852A1 (fr) |
AU (1) | AU2012238369A1 (fr) |
BR (1) | BR112013025792A2 (fr) |
CA (1) | CA2832291C (fr) |
CL (1) | CL2013002821A1 (fr) |
CO (1) | CO6801740A2 (fr) |
CR (1) | CR20130470A (fr) |
CU (1) | CU20130129A7 (fr) |
DO (1) | DOP2013000221A (fr) |
EA (1) | EA201391239A1 (fr) |
EC (1) | ECSP13013009A (fr) |
ES (1) | ES2581848T3 (fr) |
GE (1) | GEP20156417B (fr) |
GT (1) | GT201300236A (fr) |
IL (1) | IL228590A0 (fr) |
MA (1) | MA35024B1 (fr) |
MX (1) | MX2013011612A (fr) |
NI (1) | NI201300103A (fr) |
PE (1) | PE20141050A1 (fr) |
SG (1) | SG193513A1 (fr) |
TN (1) | TN2013000394A1 (fr) |
TW (1) | TWI443101B (fr) |
UA (1) | UA108926C2 (fr) |
UY (1) | UY34004A (fr) |
WO (1) | WO2012137089A1 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9193723B2 (en) * | 2012-05-11 | 2015-11-24 | Abbvie Inc. | NAMPT inhibitors |
CA2885247A1 (fr) * | 2012-10-04 | 2014-04-10 | Pfizer Limited | Inhibiteurs de kinases apparentes a la tropomyosine |
US9163021B2 (en) | 2012-10-04 | 2015-10-20 | Pfizer Limited | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors |
JP2015531394A (ja) | 2012-10-04 | 2015-11-02 | ファイザー・リミテッドPfizer Limited | ピロロ[2,3−d]ピリミジントロポミオシン関連キナーゼ阻害剤 |
JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
NZ710079A (en) | 2013-01-15 | 2020-01-31 | Incyte Holdings Corp | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors |
US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
JP2016169161A (ja) * | 2013-07-19 | 2016-09-23 | 大日本住友製薬株式会社 | 新規イミダゾピリジン化合物 |
AR097431A1 (es) | 2013-08-23 | 2016-03-16 | Incyte Corp | Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de quinasas pim |
TWI731317B (zh) | 2013-12-10 | 2021-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
WO2015089170A1 (fr) | 2013-12-12 | 2015-06-18 | Kalyra Pharmaceuticals, Inc. | Composés d'alkyle bicyclique et synthèse |
JP2016540811A (ja) | 2013-12-20 | 2016-12-28 | ファイザー・リミテッドPfizer Limited | N−アシルピペリジンエーテルトロポミオシン関連キナーゼ阻害剤 |
CA2937074A1 (fr) * | 2014-01-24 | 2015-07-30 | Abbvie Inc. | Derives furo-3-carboxamide et methodes d'utilisation |
JP6197125B2 (ja) | 2014-02-05 | 2017-09-13 | ブイエム オンコロジー リミテッド ライアビリティ カンパニー | 化合物の組成物およびその使用 |
CN113336653A (zh) | 2014-03-07 | 2021-09-03 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
WO2015143654A1 (fr) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | Inhibiteurs de la kinase trka, compositions et méthodes associées |
EP3140298A1 (fr) * | 2014-05-07 | 2017-03-15 | Pfizer Inc. | Inhibiteurs de kinases apparentées à la tropomyosine |
CN103992319B (zh) * | 2014-05-27 | 2015-09-16 | 天津市斯芬克司药物研发有限公司 | 一种吡啶羧酸类化合物的制备方法 |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
WO2016009296A1 (fr) | 2014-07-16 | 2016-01-21 | Pfizer Inc. | Inhibiteurs de kinase liés à la n-acylpipéridine éther tropomyosine |
WO2016020784A1 (fr) | 2014-08-05 | 2016-02-11 | Pfizer Inc. | Inhibiteurs de kinases apparentées à la n-acylpyrrolidine éther tropomyosine |
CA2961605C (fr) * | 2014-09-17 | 2023-01-10 | Kalyra Pharmaceuticals, Inc. | Composes bicycliques |
EP3233057A2 (fr) | 2014-12-18 | 2017-10-25 | Genzyme Corporation | Formulations pharmaceutiques d'inhibiteurs de kinase associée à la tropomyosine (trk) |
WO2016104434A1 (fr) * | 2014-12-24 | 2016-06-30 | 武田薬品工業株式会社 | Composé hétérocyclique |
CN105837574B (zh) * | 2015-02-02 | 2018-03-02 | 四川大学 | N‑(3‑哌啶基)‑芳香胺衍生物及其制备方法和用途 |
EP3288556A4 (fr) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Compositions à désintégration par voie orale |
WO2016196244A1 (fr) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Composés de pyridineamine utiles en tant qu'inhibiteurs de kinase pim |
US10550124B2 (en) | 2015-08-13 | 2020-02-04 | San Diego State University Foundation | Atropisomerism for increased kinase inhibitor selectivity |
TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Pim激酶抑制劑之鹽 |
JP6873980B2 (ja) | 2015-09-14 | 2021-05-19 | ファイザー・インク | LRRK2阻害薬としての新規のイミダゾ[4,5−c]キノリンおよびイミダゾ[4,5−c][1,5]ナフチリジン誘導体 |
US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
CN109415366B (zh) * | 2016-06-23 | 2022-02-22 | 豪夫迈·罗氏有限公司 | [1,2,3]三唑并[4,5-d]嘧啶衍生物 |
CN107011347B (zh) * | 2017-04-18 | 2019-01-18 | 华东师范大学 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的合成方法 |
NZ759268A (en) | 2017-05-15 | 2022-07-01 | Recurium Ip Holdings Llc | Bicyclo[1.1.1]pentyl compounds as analgesics |
EP3641776B1 (fr) | 2017-06-23 | 2023-10-18 | San Diego State University Research Foundation | Atropisomérisme pour une sélectivité améliorée des inhibiteurs de kinase |
AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
TW202003519A (zh) * | 2018-03-28 | 2020-01-16 | 日商武田藥品工業股份有限公司 | 雜環化合物及其用途 |
CN109053575A (zh) * | 2018-08-24 | 2018-12-21 | 遵义医学院 | 3-环丙基-1-甲基-1h-吡唑-4-甲醛的制备工艺 |
WO2020084389A1 (fr) * | 2018-10-23 | 2020-04-30 | Lupin Limited | Intermédiaire de ribociclib et son procédé de préparation |
EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
AR122141A1 (es) | 2020-05-28 | 2022-08-17 | Lilly Co Eli | Inhibidor de trka |
WO2022268080A1 (fr) * | 2021-06-21 | 2022-12-29 | 河南迈英诺医药科技有限公司 | Composé inhibiteur de la kinase trk et son utilisation |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
TW438796B (en) | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
WO2000035298A1 (fr) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing-gum contenant des agents medicamenteux actifs |
IL131582A0 (en) * | 1997-03-19 | 2001-01-28 | Basf Ag | Pyrrolo [2,3d] pyrimidines and their use as tyrosine kinase inhibitors |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
WO2001072751A1 (fr) * | 2000-03-29 | 2001-10-04 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines utilisees comme inhibiteurs de tyrosine kinases |
JP2003321472A (ja) | 2002-02-26 | 2003-11-11 | Takeda Chem Ind Ltd | Grk阻害剤 |
GB0218168D0 (en) * | 2002-08-06 | 2002-09-11 | Astrazeneca Ab | Compounds |
UA80171C2 (en) | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
US20070185079A1 (en) | 2004-01-07 | 2007-08-09 | Astrazeneca Ab | Therapeutic agents I |
US7417063B2 (en) | 2004-04-13 | 2008-08-26 | Bristol-Myers Squibb Company | Bicyclic heterocycles useful as serine protease inhibitors |
CA2566160C (fr) * | 2004-05-27 | 2011-01-18 | Pfizer Products Inc. | Derives pyrrolopyrimidiniques convenant au traitement du cancer |
BRPI0610066A2 (pt) * | 2005-05-17 | 2010-05-25 | Plexxikon Inc | compostos que modulam atividade de c-kit e c-fms e usos para estes |
WO2007042545A1 (fr) | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Derives d'imidazole utilises pour moduler le complexe du recepteur gaba-a |
GB0526044D0 (en) | 2005-12-21 | 2006-02-01 | Syngenta Ltd | Novel herbicides |
RU2323058C1 (ru) | 2006-07-12 | 2008-04-27 | ООО Научно-внедренческий центр "Машины и оборудование для энергетики" | Способ формирования наружной резьбы на концевом участке трубной заготовки |
PT2076508E (pt) | 2006-10-18 | 2011-03-07 | Pfizer Prod Inc | Compostos de ureia de éter biarílico |
AU2007336811A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
US8357711B2 (en) | 2007-03-23 | 2013-01-22 | Pfizer Limited | Heterocyclic sulfonamides as inhibitors of ion channels |
KR20100007956A (ko) | 2007-05-03 | 2010-01-22 | 화이자 리미티드 | 나트륨 채널 조절제로서의 2-피리딘 카복스아마이드 유도체 |
EP2173743A2 (fr) | 2007-07-13 | 2010-04-14 | Icagen, Inc. | Inhibiteurs des canaux sodiques |
BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
US8158636B2 (en) | 2008-05-19 | 2012-04-17 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
WO2009152087A1 (fr) | 2008-06-10 | 2009-12-17 | Plexxikon, Inc. | Composés hétéroaryles bicycliques et procédés destinés à la modulation de kinases, et des indications pour celle-ci |
JP5767965B2 (ja) | 2008-06-10 | 2015-08-26 | プレキシコン インコーポレーテッドPlexxikon Inc. | キナーゼを調節する5h−ピロロ[2,3−b]ピラジン誘導体、およびその適応症 |
BRPI1006128A2 (pt) | 2009-01-12 | 2016-11-01 | Cagen Inc | derivados de sulfonamida |
KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
TWI510487B (zh) | 2010-04-21 | 2015-12-01 | Plexxikon Inc | 用於激酶調節的化合物和方法及其適應症 |
-
2012
- 2012-03-22 BR BR112013025792A patent/BR112013025792A2/pt not_active IP Right Cessation
- 2012-03-22 AU AU2012238369A patent/AU2012238369A1/en not_active Abandoned
- 2012-03-22 CA CA2832291A patent/CA2832291C/fr not_active Expired - Fee Related
- 2012-03-22 EA EA201391239A patent/EA201391239A1/ru unknown
- 2012-03-22 SG SG2013070032A patent/SG193513A1/en unknown
- 2012-03-22 KR KR1020137029237A patent/KR20130133905A/ko active IP Right Grant
- 2012-03-22 EP EP12713362.7A patent/EP2694509B1/fr active Active
- 2012-03-22 JP JP2014503236A patent/JP5595616B2/ja not_active Expired - Fee Related
- 2012-03-22 GE GEAP201213253A patent/GEP20156417B/en unknown
- 2012-03-22 AP AP2013007159A patent/AP2013007159A0/xx unknown
- 2012-03-22 MA MA36302A patent/MA35024B1/fr unknown
- 2012-03-22 UA UAA201311548A patent/UA108926C2/ru unknown
- 2012-03-22 PE PE2013002178A patent/PE20141050A1/es not_active Application Discontinuation
- 2012-03-22 ES ES12713362.7T patent/ES2581848T3/es active Active
- 2012-03-22 MX MX2013011612A patent/MX2013011612A/es unknown
- 2012-03-22 WO PCT/IB2012/051363 patent/WO2012137089A1/fr active Application Filing
- 2012-03-22 CN CN201280022159.2A patent/CN103534257A/zh active Pending
- 2012-03-30 UY UY0001034004A patent/UY34004A/es not_active Application Discontinuation
- 2012-04-02 TW TW101111719A patent/TWI443101B/zh not_active IP Right Cessation
- 2012-04-04 AR ARP120101171A patent/AR085852A1/es unknown
- 2012-04-04 US US13/439,131 patent/US8846698B2/en not_active Expired - Fee Related
-
2013
- 2013-09-17 CR CR20130470A patent/CR20130470A/es unknown
- 2013-09-27 TN TNP2013000394A patent/TN2013000394A1/fr unknown
- 2013-09-29 IL IL228590A patent/IL228590A0/en unknown
- 2013-09-30 CU CU2013000129A patent/CU20130129A7/es unknown
- 2013-09-30 CL CL2013002821A patent/CL2013002821A1/es unknown
- 2013-10-03 NI NI201300103A patent/NI201300103A/es unknown
- 2013-10-04 DO DO2013000221A patent/DOP2013000221A/es unknown
- 2013-10-04 CO CO13236624A patent/CO6801740A2/es active IP Right Grant
- 2013-10-04 GT GT201300236A patent/GT201300236A/es unknown
- 2013-11-05 EC ECSP13013009 patent/ECSP13013009A/es unknown
-
2014
- 2014-08-26 US US14/468,614 patent/US20140364415A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TN2013000394A1 (fr) | Derives de pyrrolo [2,3-d] pyrimidine servant d'inhibiteurs de kinases apparentees a la tropomyosine | |
EA201390199A1 (ru) | 2-замещенные-8-алкил-7-оксо-7,8-дигидропиридо[2,3-d]пиримидин-6-карбонитрилы и их применение | |
NZ702571A (en) | 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors | |
GEP201706774B (en) | Heterocyclyl compounds | |
NZ626394A (en) | Substituted annulated pyrimidines and triazines, and use thereof | |
GEP201606507B (en) | Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors | |
MD4735B1 (ro) | Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK) | |
EA201100580A1 (ru) | Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
SG11201408052WA (en) | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS | |
CO6831982A2 (es) | Pirazolo[4,3-d]pirimidinas útiles como inhibidores de cinasas | |
RS54339B1 (en) | NEW ANTIMALARIAN AGENTS | |
EA201490912A1 (ru) | Производные [1,2,3]триазоло[4,5-d]пиримидина в качестве агонистов каннабиноидного рецептора 2 | |
EA201490971A1 (ru) | Производные урацила в качестве ингибиторов axl и c-met киназы | |
MD4582B1 (ro) | Derivaţi ai 1-fenil-1H-benzimidazolului ca inhibitori ai protein kinazei | |
MD20140023A2 (ro) | Derivaţi de pirolpirimidină şi purină | |
PH12015500360A1 (en) | Pyrazolopyrimidine compound | |
EA201590224A1 (ru) | Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
NZ703714A (en) | 2-aminopyrazine derivatives as csf-1 r kinase inhibitors | |
JO3115B1 (ar) | مركبات بيريدازينون واستخدامها كمثبطات daao | |
CR20200286A (es) | DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294) | |
JP2016540803A5 (fr) | ||
WO2014053968A8 (fr) | Inhibiteurs de kinase associée à la tropomyosine pyrrolo[3,2-c]pyridine | |
EA200800920A1 (ru) | Производные пиразоло[4,3-d]пиримидин-5-ила, применяемые в качестве ингибиторов фосфодиэстеразы 5 (pde5) | |
TN2014000519A1 (en) | Pyrimidinone derivatives as antimalarial agents | |
RS54458B1 (en) | TIENO [2,3-D] PYRIMIDINE DERIVATIVES AND THEIR APPLICATIONS IN THE TREATMENT OF ARITHMIA |