NI201300103A - INHIBIDORES DE QUINASA RELACIONADOS CON PIRROLO [ 2, 3-d] PIRIMIDINA TROPOMIOSINA - Google Patents
INHIBIDORES DE QUINASA RELACIONADOS CON PIRROLO [ 2, 3-d] PIRIMIDINA TROPOMIOSINAInfo
- Publication number
- NI201300103A NI201300103A NI201300103A NI201300103A NI201300103A NI 201300103 A NI201300103 A NI 201300103A NI 201300103 A NI201300103 A NI 201300103A NI 201300103 A NI201300103 A NI 201300103A NI 201300103 A NI201300103 A NI 201300103A
- Authority
- NI
- Nicaragua
- Prior art keywords
- pirrolo
- tropomyosin
- pyrimidine
- kinase inhibitors
- inhibitors related
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La presente invención se refiere a compuestos de Fórmula (I) y sus sales aceptables para uso farmacéutico donde los sustituyentes son como se describen en la presente, y su uso en medicina, en particular como antagonistas de Trk.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161471758P | 2011-04-05 | 2011-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201300103A true NI201300103A (es) | 2014-02-12 |
Family
ID=45937493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201300103A NI201300103A (es) | 2011-04-05 | 2013-10-03 | INHIBIDORES DE QUINASA RELACIONADOS CON PIRROLO [ 2, 3-d] PIRIMIDINA TROPOMIOSINA |
Country Status (31)
Country | Link |
---|---|
US (2) | US8846698B2 (es) |
EP (1) | EP2694509B1 (es) |
JP (1) | JP5595616B2 (es) |
KR (1) | KR20130133905A (es) |
CN (1) | CN103534257A (es) |
AP (1) | AP2013007159A0 (es) |
AR (1) | AR085852A1 (es) |
AU (1) | AU2012238369A1 (es) |
BR (1) | BR112013025792A2 (es) |
CA (1) | CA2832291C (es) |
CL (1) | CL2013002821A1 (es) |
CO (1) | CO6801740A2 (es) |
CR (1) | CR20130470A (es) |
CU (1) | CU20130129A7 (es) |
DO (1) | DOP2013000221A (es) |
EA (1) | EA201391239A1 (es) |
EC (1) | ECSP13013009A (es) |
ES (1) | ES2581848T3 (es) |
GE (1) | GEP20156417B (es) |
GT (1) | GT201300236A (es) |
IL (1) | IL228590A0 (es) |
MA (1) | MA35024B1 (es) |
MX (1) | MX2013011612A (es) |
NI (1) | NI201300103A (es) |
PE (1) | PE20141050A1 (es) |
SG (1) | SG193513A1 (es) |
TN (1) | TN2013000394A1 (es) |
TW (1) | TWI443101B (es) |
UA (1) | UA108926C2 (es) |
UY (1) | UY34004A (es) |
WO (1) | WO2012137089A1 (es) |
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PE20150224A1 (es) * | 2012-05-11 | 2015-03-08 | Abbvie Inc | Inhibidores del nampt |
CA2885259A1 (en) | 2012-10-04 | 2014-04-10 | Pfizer Limited | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors |
US20150218172A1 (en) | 2012-10-04 | 2015-08-06 | Pfizer Limited | Pyrrolo[2,3-D]Pyrimidine Tropomyosin-Related Kinase Inhibitors |
JP2015531393A (ja) * | 2012-10-04 | 2015-11-02 | ファイザー・リミテッドPfizer Limited | トロポミオシン関連キナーゼ阻害剤 |
WO2014110574A1 (en) | 2013-01-14 | 2014-07-17 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
SG11201505347VA (en) | 2013-01-15 | 2015-08-28 | Incyte Corp | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors |
TWI630194B (zh) | 2013-03-14 | 2018-07-21 | 凱立拉製藥公司 | 雙環止痛化合物 |
JP2016169161A (ja) * | 2013-07-19 | 2016-09-23 | 大日本住友製薬株式会社 | 新規イミダゾピリジン化合物 |
US9556197B2 (en) | 2013-08-23 | 2017-01-31 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
TWI663159B (zh) | 2013-12-10 | 2019-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
US10189780B2 (en) | 2013-12-12 | 2019-01-29 | Zeno Royalties & Milestones, LLC | Bicyclic alkyl compounds and synthesis |
WO2015092610A1 (en) | 2013-12-20 | 2015-06-25 | Pfizer Limited | N-acylpiperidine ether tropomyosin-related kinase inhibitors |
US9777020B2 (en) * | 2014-01-24 | 2017-10-03 | Abbvie Inc. | Furo-3-carboxamide derivatives and methods of use |
PL3102555T3 (pl) | 2014-02-05 | 2021-12-20 | VM Oncology LLC | Kompozycje związków i ich zastosowania |
WO2015134710A1 (en) | 2014-03-07 | 2015-09-11 | Kalyra Pharmaceuticals, Inc. | Propellane derivates and synthesis |
WO2015143654A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
EP3140298A1 (en) * | 2014-05-07 | 2017-03-15 | Pfizer Inc. | Tropomyosin-related kinase inhibitors |
CN103992319B (zh) * | 2014-05-27 | 2015-09-16 | 天津市斯芬克司药物研发有限公司 | 一种吡啶羧酸类化合物的制备方法 |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
WO2016009296A1 (en) | 2014-07-16 | 2016-01-21 | Pfizer Inc. | N-acylpiperidine ether tropomyosin-related kinase inhibitors |
WO2016020784A1 (en) | 2014-08-05 | 2016-02-11 | Pfizer Inc. | N-acylpyrrolidine ether tropomyosin-related kinase inhibitors |
US10308609B2 (en) * | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
CN107231803B (zh) | 2014-12-18 | 2019-12-03 | 建新公司 | 原肌球蛋白相关激酶(trk)抑制剂的药物制剂 |
US10202376B2 (en) | 2014-12-24 | 2019-02-12 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN105837574B (zh) * | 2015-02-02 | 2018-03-02 | 四川大学 | N‑(3‑哌啶基)‑芳香胺衍生物及其制备方法和用途 |
EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
US10550124B2 (en) | 2015-08-13 | 2020-02-04 | San Diego State University Foundation | Atropisomerism for increased kinase inhibitor selectivity |
AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
JP7090037B2 (ja) * | 2016-06-23 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | 新規な[1,2,3]トリアゾロ[4,5-d]ピリミジン誘導体 |
CN107011347B (zh) * | 2017-04-18 | 2019-01-18 | 华东师范大学 | 一种4-氯-7H-吡咯并[2,3-d]嘧啶的合成方法 |
JP7157769B2 (ja) | 2017-05-15 | 2022-10-20 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 鎮痛剤化合物 |
EP3641776B1 (en) | 2017-06-23 | 2023-10-18 | San Diego State University Research Foundation | Atropisomerism for enhanced kinase inhibitor selectivity |
WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
MA52214A (fr) * | 2018-03-28 | 2021-04-21 | Takeda Pharmaceuticals Co | Composé hétérocyclique et son utilisation |
CN109053575A (zh) * | 2018-08-24 | 2018-12-21 | 遵义医学院 | 3-环丙基-1-甲基-1h-吡唑-4-甲醛的制备工艺 |
WO2020084389A1 (en) * | 2018-10-23 | 2020-04-30 | Lupin Limited | Ribociclib intermediate and process for preparation thereof |
CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
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TW202210467A (zh) | 2020-05-28 | 2022-03-16 | 美商美國禮來大藥廠 | TrkA抑制劑 |
EP4357347A1 (en) * | 2021-06-21 | 2024-04-24 | Henan Medinno Pharmaceutical Technology Co., Ltd. | Trk kinase inhibitor compound and use thereof |
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KR101483215B1 (ko) * | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
TWI619713B (zh) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
-
2012
- 2012-03-22 JP JP2014503236A patent/JP5595616B2/ja not_active Expired - Fee Related
- 2012-03-22 MX MX2013011612A patent/MX2013011612A/es unknown
- 2012-03-22 BR BR112013025792A patent/BR112013025792A2/pt not_active IP Right Cessation
- 2012-03-22 ES ES12713362.7T patent/ES2581848T3/es active Active
- 2012-03-22 AP AP2013007159A patent/AP2013007159A0/xx unknown
- 2012-03-22 WO PCT/IB2012/051363 patent/WO2012137089A1/en active Application Filing
- 2012-03-22 UA UAA201311548A patent/UA108926C2/ru unknown
- 2012-03-22 CN CN201280022159.2A patent/CN103534257A/zh active Pending
- 2012-03-22 EA EA201391239A patent/EA201391239A1/ru unknown
- 2012-03-22 AU AU2012238369A patent/AU2012238369A1/en not_active Abandoned
- 2012-03-22 SG SG2013070032A patent/SG193513A1/en unknown
- 2012-03-22 MA MA36302A patent/MA35024B1/fr unknown
- 2012-03-22 PE PE2013002178A patent/PE20141050A1/es not_active Application Discontinuation
- 2012-03-22 KR KR1020137029237A patent/KR20130133905A/ko active IP Right Grant
- 2012-03-22 EP EP12713362.7A patent/EP2694509B1/en active Active
- 2012-03-22 GE GEAP201213253A patent/GEP20156417B/en unknown
- 2012-03-22 CA CA2832291A patent/CA2832291C/en not_active Expired - Fee Related
- 2012-03-30 UY UY0001034004A patent/UY34004A/es not_active Application Discontinuation
- 2012-04-02 TW TW101111719A patent/TWI443101B/zh not_active IP Right Cessation
- 2012-04-04 US US13/439,131 patent/US8846698B2/en not_active Expired - Fee Related
- 2012-04-04 AR ARP120101171A patent/AR085852A1/es unknown
-
2013
- 2013-09-17 CR CR20130470A patent/CR20130470A/es unknown
- 2013-09-27 TN TNP2013000394A patent/TN2013000394A1/fr unknown
- 2013-09-29 IL IL228590A patent/IL228590A0/en unknown
- 2013-09-30 CL CL2013002821A patent/CL2013002821A1/es unknown
- 2013-09-30 CU CU2013000129A patent/CU20130129A7/es unknown
- 2013-10-03 NI NI201300103A patent/NI201300103A/es unknown
- 2013-10-04 CO CO13236624A patent/CO6801740A2/es active IP Right Grant
- 2013-10-04 DO DO2013000221A patent/DOP2013000221A/es unknown
- 2013-10-04 GT GT201300236A patent/GT201300236A/es unknown
- 2013-11-05 EC ECSP13013009 patent/ECSP13013009A/es unknown
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2014
- 2014-08-26 US US14/468,614 patent/US20140364415A1/en not_active Abandoned
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