US7081454B2
(en)
|
2001-03-28 |
2006-07-25 |
Bristol-Myers Squibb Co. |
Tyrosine kinase inhibitors
|
AR035885A1
(en)
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
DERIVATIVES OF 4-AMINO-5-FENIL-7-CYCLLOBUTILPIRROLO (2,3-D) PYRIMIDINE, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION
|
MXPA04007832A
(en)
|
2002-02-11 |
2005-09-08 |
Bayer Pharmaceuticals Corp |
Aryl ureas with angiogenesis inhibiting activity.
|
US20030199525A1
(en)
*
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
AU2003246972A1
(en)
|
2002-08-06 |
2004-02-23 |
Astrazeneca Ab |
Condensed pyridines and pyrimidines with tie2 (tek) activity
|
AU2003297048A1
(en)
|
2002-12-13 |
2004-07-09 |
Smithkline Beecham Corporation |
Cyclohexyl compounds as ccr5 antagonists
|
UA80171C2
(en)
|
2002-12-19 |
2007-08-27 |
Pfizer Prod Inc |
Pyrrolopyrimidine derivatives
|
AR045037A1
(en)
|
2003-07-10 |
2005-10-12 |
Aventis Pharma Sa |
TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE.
|
US7312215B2
(en)
|
2003-07-29 |
2007-12-25 |
Bristol-Myers Squibb Company |
Benzimidazole C-2 heterocycles as kinase inhibitors
|
JP4916883B2
(en)
|
2003-10-15 |
2012-04-18 |
オーエスアイ・ファーマスーティカルズ・インコーポレーテッド |
Imidazopyrazine tyrosine kinase inhibitor
|
GB0401334D0
(en)
*
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
CA2553724A1
(en)
*
|
2004-02-03 |
2005-08-18 |
Abbott Laboratories |
Aminobenzoxazoles as therapeutic agents
|
WO2005097800A1
(en)
*
|
2004-04-02 |
2005-10-20 |
Osi Pharmaceuticals, Inc. |
6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
|
US7550499B2
(en)
|
2004-05-12 |
2009-06-23 |
Bristol-Myers Squibb Company |
Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
WO2005116035A1
(en)
*
|
2004-05-27 |
2005-12-08 |
Pfizer Products Inc. |
Pyrrolopyrimidine derivatives useful in cancer treatment
|
AR053090A1
(en)
|
2004-07-20 |
2007-04-25 |
Osi Pharm Inc |
IMIDAZOTRIAZINS AS PROTEIN KINASE INHIBITORS AND THEIR USE FOR THE PREPARATION OF MEDICINES
|
US7465726B2
(en)
|
2004-08-02 |
2008-12-16 |
Osi Pharmaceuticals, Inc. |
Substituted pyrrolo[2.3-B]pyridines
|
WO2006078621A2
(en)
|
2005-01-19 |
2006-07-27 |
Bristol-Myers Squibb Company |
2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders
|
EP1899299B1
(en)
|
2005-06-27 |
2010-10-20 |
Bristol-Myers Squibb Company |
C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
|
KR20080027890A
(en)
|
2005-06-27 |
2008-03-28 |
브리스톨-마이어스 스큅 컴퍼니 |
N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
|
US7714002B2
(en)
|
2005-06-27 |
2010-05-11 |
Bristol-Myers Squibb Company |
Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
US7816382B2
(en)
|
2005-06-27 |
2010-10-19 |
Bristol-Myers Squibb Company |
Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition
|
US7566721B2
(en)
|
2005-08-08 |
2009-07-28 |
Osi Pharmaceuticals, Inc. |
Substituted thienol[2,3-d]pyrimidines as kinase inhibitors
|
WO2007035744A1
(en)
|
2005-09-20 |
2007-03-29 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
AR057960A1
(en)
|
2005-12-02 |
2007-12-26 |
Osi Pharm Inc |
BICYCLE PROTEIN QUINASE INHIBITORS
|
US8575164B2
(en)
|
2005-12-19 |
2013-11-05 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy
|
US7960569B2
(en)
|
2006-10-17 |
2011-06-14 |
Bristol-Myers Squibb Company |
Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
|
JP5572388B2
(en)
|
2006-11-22 |
2014-08-13 |
インサイト・コーポレイション |
Imidazotriazines and imidazopyrimidines as kinase inhibitors
|
NZ586642A
(en)
|
2008-01-11 |
2012-04-27 |
Natco Pharma Ltd |
Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents
|
JP2011520970A
(en)
|
2008-05-19 |
2011-07-21 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
Substituted imidazopyrazines and imidazotriazines
|
EP2358720B1
(en)
*
|
2008-10-16 |
2016-03-02 |
The Regents of The University of California |
Fused ring heteroaryl kinase inhibitors
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
WO2010099137A2
(en)
|
2009-02-26 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the emt status of tumor cells in vivo
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
JP2012519282A
(en)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Methods for identifying mesenchymal tumor cells or agents that inhibit their production
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
WO2010123792A1
(en)
|
2009-04-20 |
2010-10-28 |
Osi Pharmaceuticals, Inc. |
Preparation of c-pyrazine-methylamines
|
CN102596963A
(en)
*
|
2009-09-10 |
2012-07-18 |
诺瓦提斯公司 |
Ether derivatives of bicyclic heteroaryls
|
JP2013527748A
(en)
|
2010-03-03 |
2013-07-04 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Biological markers useful for predicting anticancer responses to insulin-like growth factor 1 receptor kinase inhibitors
|
US20110217309A1
(en)
|
2010-03-03 |
2011-09-08 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
JP2013522215A
(en)
|
2010-03-09 |
2013-06-13 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Combined anticancer therapy
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
MX2013011612A
(en)
*
|
2011-04-05 |
2013-10-17 |
Pfizer Ltd |
Pyrrolo [2, 3 -d] pyrimidine derivatives as inhibitors of tropomyosin- related kinases.
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
PL2710005T3
(en)
|
2011-05-17 |
2017-07-31 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
WO2013010136A2
(en)
|
2011-07-13 |
2013-01-17 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
JP6342805B2
(en)
|
2011-09-02 |
2018-06-13 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Substituted pyrazolo [3,4-D] pyrimidine and uses thereof
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
ES2731833T3
(en)
|
2012-09-10 |
2019-11-19 |
Principia Biopharma Inc |
Pyrazolopyrimidine compounds as kinase inhibitors
|
BR112015006828A8
(en)
|
2012-09-26 |
2019-09-17 |
Univ California |
compound, or a pharmaceutically acceptable salt thereof; pharmaceutical composition; use of the compound; and method for modulating the activity of an ire1 protein
|
US8957080B2
(en)
|
2013-04-09 |
2015-02-17 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
EP3816155A1
(en)
*
|
2013-08-23 |
2021-05-05 |
Virginia Commonwealth University |
Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
|
PE20160560A1
(en)
|
2013-09-30 |
2016-06-09 |
Pharmacyclics Llc |
DERIVATIVES OF PIRAZOLO [3,4-d] PYRIMIDIN AS IRREVERSIBLE INHIBITORS OF BRUTON TYROSINE KINASE (BTK)
|
JP6493218B2
(en)
*
|
2013-11-08 |
2019-04-03 |
小野薬品工業株式会社 |
Pyrrolopyrimidine derivatives
|
CA2834528A1
(en)
*
|
2013-11-26 |
2015-05-26 |
Pharmascience Inc. |
Protein kinase inhibitors
|
EA201691302A1
(en)
|
2014-02-03 |
2017-03-31 |
Кадила Хелзкэр Лимитед |
NEW HETEROCYCLIC COMPOUNDS
|
SG11201606858RA
(en)
|
2014-02-21 |
2016-09-29 |
Principia Biopharma Inc |
Salts and solid form of a btk inhibitor
|
MA41197B1
(en)
|
2014-12-18 |
2021-01-29 |
Principia Biopharma Inc |
Treatment of pemphigus
|
US20180305350A1
(en)
|
2015-06-24 |
2018-10-25 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
ES2929528T3
(en)
*
|
2015-09-16 |
2022-11-29 |
Loxo Oncology Inc |
Pyrazolopyrimidine derivatives as BTK inhibitors for cancer treatment
|
EP3383390A4
(en)
*
|
2015-12-02 |
2019-11-20 |
Astraea Therapeutics, LLC |
Piperidinyl nociceptin receptor compounds
|
US10112924B2
(en)
|
2015-12-02 |
2018-10-30 |
Astraea Therapeutics, Inc. |
Piperdinyl nociceptin receptor compounds
|
CN107513068A
(en)
*
|
2016-06-16 |
2017-12-26 |
中国科学院上海药物研究所 |
A kind of new compound and its preparation and application with FGFR inhibitory activity
|
IL263815B
(en)
|
2016-06-29 |
2022-07-01 |
Principia Biopharma Inc |
Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
|
CN112689637B
(en)
|
2018-09-13 |
2023-11-10 |
橘生药品工业株式会社 |
Imidazopyridone compounds
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
IL302807A
(en)
|
2020-11-18 |
2023-07-01 |
Deciphera Pharmaceuticals Llc |
Gcn2 and perk kinase inhibitors and methods of use thereof
|