EA201591939A1 - ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРА CB2 - Google Patents

ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРА CB2

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Publication number
EA201591939A1
EA201591939A1 EA201591939A EA201591939A EA201591939A1 EA 201591939 A1 EA201591939 A1 EA 201591939A1 EA 201591939 A EA201591939 A EA 201591939A EA 201591939 A EA201591939 A EA 201591939A EA 201591939 A1 EA201591939 A1 EA 201591939A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolo
agonists
receptor
pyrimidine derivatives
compound
Prior art date
Application number
EA201591939A
Other languages
English (en)
Other versions
EA028123B1 (ru
Inventor
Уве Гретер
Ацуси Кимбара
Маттиас Неттекофен
Штефан Рёфер
Марк Роджерс-Эванс
Танья Шульц-Гаш
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201591939A1 publication Critical patent/EA201591939A1/ru
Publication of EA028123B1 publication Critical patent/EA028123B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Изобретение относится к соединению формулы (I)где A и R-Rявляются такими, как определено в описании и формуле изобретения. Соединение формулы (I) может быть использовано в качестве лекарственного средства.
EA201591939A 2013-05-02 2014-04-29 ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРА CB2 EA028123B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13166296 2013-05-02
PCT/EP2014/058648 WO2014177527A1 (en) 2013-05-02 2014-04-29 Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists

Publications (2)

Publication Number Publication Date
EA201591939A1 true EA201591939A1 (ru) 2016-03-31
EA028123B1 EA028123B1 (ru) 2017-10-31

Family

ID=48190401

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591939A EA028123B1 (ru) 2013-05-02 2014-04-29 ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРА CB2

Country Status (35)

Country Link
US (1) US9580435B2 (ru)
EP (1) EP2991988B1 (ru)
JP (1) JP6454689B2 (ru)
KR (1) KR20160002857A (ru)
CN (1) CN105164133B (ru)
AR (1) AR096153A1 (ru)
AU (1) AU2014261546B2 (ru)
BR (1) BR112015027394A8 (ru)
CA (1) CA2907691A1 (ru)
CL (1) CL2015003196A1 (ru)
CR (1) CR20150555A (ru)
CY (1) CY1119114T1 (ru)
DK (1) DK2991988T3 (ru)
EA (1) EA028123B1 (ru)
ES (1) ES2635632T3 (ru)
HK (1) HK1213559A1 (ru)
HR (1) HRP20171099T1 (ru)
HU (1) HUE035333T2 (ru)
IL (1) IL242162B (ru)
LT (1) LT2991988T (ru)
MA (1) MA38555B1 (ru)
MX (1) MX2015014081A (ru)
MY (1) MY182237A (ru)
NZ (1) NZ712030A (ru)
PE (1) PE20160039A1 (ru)
PH (1) PH12015502409B1 (ru)
PL (1) PL2991988T3 (ru)
PT (1) PT2991988T (ru)
RS (1) RS56313B1 (ru)
SG (1) SG11201509029PA (ru)
SI (1) SI2991988T1 (ru)
TW (1) TWI680129B (ru)
UA (1) UA116801C2 (ru)
WO (1) WO2014177527A1 (ru)
ZA (1) ZA201507008B (ru)

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PT3483163T (pt) 2013-09-06 2021-08-24 Hoffmann La Roche Novos derivados de triazolo[4,5-d]pirimidina como antagonistas de receptor cb2
EP3215506B1 (en) * 2014-11-07 2019-01-02 F.Hoffmann-La Roche Ag Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2
CN109311895B (zh) 2016-06-23 2021-06-18 豪夫迈·罗氏有限公司 新型[1,2,3]三唑并[4,5-d]嘧啶衍生物
JP7090037B2 (ja) 2016-06-23 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー 新規な［１，２，３］トリアゾロ［４，５－ｄ］ピリミジン誘導体
EP4108665A1 (en) 2016-06-23 2022-12-28 F. Hoffmann-La Roche AG [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
EP3475281A1 (en) 2016-06-23 2019-05-01 H. Hoffnabb-La Roche Ag Novel [1,2,31triazolo[4,5-d]pyrimidine derivatives
AU2021341508A1 (en) 2020-09-10 2023-05-25 Precirix N.V. Antibody fragment against fap
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

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WO2001058869A2 (en) 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
WO2003082191A2 (en) 2002-03-28 2003-10-09 Merck & Co., Inc. Substituted 2,3-diphenyl pyridines
DE10219435A1 (de) 2002-05-02 2003-11-13 Bayer Cropscience Ag Substituierte Pyrazolo-pyrimidin-4-one
AR042667A1 (es) * 2002-12-26 2005-06-29 Taisho Pharmaceutical Co Ltd Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico
AR051596A1 (es) 2004-10-26 2007-01-24 Irm Llc Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios
PL1999132T3 (pl) * 2006-03-30 2012-12-31 Irm Llc Azolopirymidyny jako inhibitory aktywności Receptora Kannabinoidowego typu 1
EP2155747B1 (en) * 2007-05-10 2012-10-24 GE Healthcare Limited Imidazol (1,2-a)pyridines and related compounds with activity at cannabinoid cb2 receptors
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PL2991987T3 (pl) 2013-05-02 2018-10-31 F. Hoffmann-La Roche Ag Pochodne purynowe jako agoniści receptora CB2

Also Published As

Publication number Publication date
ZA201507008B (en) 2017-08-30
PE20160039A1 (es) 2016-01-28
IL242162B (en) 2019-06-30
EA028123B1 (ru) 2017-10-31
RS56313B1 (sr) 2017-12-29
PL2991988T3 (pl) 2017-10-31
AU2014261546B2 (en) 2018-01-18
DK2991988T3 (en) 2017-08-21
PT2991988T (pt) 2017-07-25
JP2016517874A (ja) 2016-06-20
JP6454689B2 (ja) 2019-01-16
SI2991988T1 (sl) 2017-09-29
EP2991988B1 (en) 2017-05-31
ES2635632T3 (es) 2017-10-04
TW201522343A (zh) 2015-06-16
CY1119114T1 (el) 2018-02-14
MA38555B1 (fr) 2018-04-30
MX2015014081A (es) 2015-12-11
CR20150555A (es) 2015-11-20
UA116801C2 (uk) 2018-05-10
TWI680129B (zh) 2019-12-21
US9580435B2 (en) 2017-02-28
KR20160002857A (ko) 2016-01-08
CN105164133B (zh) 2018-02-13
CA2907691A1 (en) 2014-11-06
AU2014261546A1 (en) 2015-09-24
PH12015502409A1 (en) 2016-02-22
US20160046637A1 (en) 2016-02-18
WO2014177527A1 (en) 2014-11-06
HK1213559A1 (zh) 2016-07-08
HRP20171099T1 (hr) 2017-10-06
MA38555A1 (fr) 2017-09-29
CN105164133A (zh) 2015-12-16
MY182237A (en) 2021-01-18
AR096153A1 (es) 2015-12-09
HUE035333T2 (en) 2018-05-02
BR112015027394A2 (pt) 2017-07-25
BR112015027394A8 (pt) 2018-01-30
CL2015003196A1 (es) 2016-06-03
LT2991988T (lt) 2017-08-10
NZ712030A (en) 2021-03-26
EP2991988A1 (en) 2016-03-09
PH12015502409B1 (en) 2016-02-22
SG11201509029PA (en) 2015-12-30

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