UA111640C2 - ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 - Google Patents
ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2Info
- Publication number
- UA111640C2 UA111640C2 UAA201406094A UAA201406094A UA111640C2 UA 111640 C2 UA111640 C2 UA 111640C2 UA A201406094 A UAA201406094 A UA A201406094A UA A201406094 A UAA201406094 A UA A201406094A UA 111640 C2 UA111640 C2 UA 111640C2
- Authority
- UA
- Ukraine
- Prior art keywords
- triazolo
- pyrimidine
- derivatives
- cannabinoid receptor
- receptor agonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Даний винахід стосується сполуки формули (І):, (І)у якій A, Rта Rрозкриті в описі та формулі винаходу. Сполуку формули (І) можна застосовувати як лікарський засіб, як антагоніст канабіноїдного рецептора 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11188333 | 2011-11-08 | ||
PCT/EP2012/071788 WO2013068306A1 (en) | 2011-11-08 | 2012-11-05 | [1, 2, 3] triazolo [4, 5 -d] pyrimidine derivatives as agonists of the cannabinoid receptor 2 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA111640C2 true UA111640C2 (uk) | 2016-05-25 |
Family
ID=47116003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201406094A UA111640C2 (uk) | 2011-11-08 | 2012-05-11 | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
Country Status (31)
Country | Link |
---|---|
US (2) | US8741906B2 (uk) |
EP (1) | EP2776442B1 (uk) |
JP (1) | JP6138141B2 (uk) |
KR (1) | KR102032337B1 (uk) |
CN (1) | CN103930426B (uk) |
AR (1) | AR088663A1 (uk) |
AU (1) | AU2012334173B2 (uk) |
BR (1) | BR112014011055B1 (uk) |
CA (1) | CA2850458C (uk) |
CL (1) | CL2014001174A1 (uk) |
CO (1) | CO6920295A2 (uk) |
CY (1) | CY1117147T1 (uk) |
DK (1) | DK2776442T3 (uk) |
EA (1) | EA023581B1 (uk) |
ES (1) | ES2553704T3 (uk) |
HK (1) | HK1194732A1 (uk) |
HR (1) | HRP20160052T1 (uk) |
HU (1) | HUE025543T2 (uk) |
IL (1) | IL231949A (uk) |
MX (1) | MX342309B (uk) |
MY (1) | MY170878A (uk) |
PE (1) | PE20141588A1 (uk) |
PL (1) | PL2776442T3 (uk) |
PT (1) | PT2776442E (uk) |
RS (1) | RS54436B1 (uk) |
SG (1) | SG11201402197UA (uk) |
SI (1) | SI2776442T1 (uk) |
TW (2) | TWI704150B (uk) |
UA (1) | UA111640C2 (uk) |
WO (1) | WO2013068306A1 (uk) |
ZA (1) | ZA201402905B (uk) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA111640C2 (uk) * | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
US9067943B2 (en) * | 2011-11-25 | 2015-06-30 | Hoffmann-La Roche Inc. | [1,2,3]triazolo[4,5-D]pyrimidine derivatives |
SG11201507168XA (en) | 2013-03-07 | 2015-10-29 | Hoffmann La Roche | Novel pyrazol derivatives |
BR112015024272A2 (pt) | 2013-03-26 | 2017-07-18 | Hoffmann La Roche | novos derivados de piridina |
SG11201509029PA (en) | 2013-05-02 | 2015-12-30 | Hoffmann La Roche | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
BR112015027396B1 (pt) | 2013-05-02 | 2023-04-11 | F. Hoffmann-La Roche Ag | Derivados de purina como agonistas do receptor de cb2 |
CA2915766C (en) * | 2013-09-06 | 2023-09-26 | F. Hoffmann-La Roche Ag | Triazolo[4,5-d]pyrimidine derivatives and their use as cannabinoid receptor 2 agonists |
EP3177611B1 (en) * | 2014-08-04 | 2021-10-06 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
CA2960794A1 (en) * | 2014-11-07 | 2016-05-12 | F. Hoffmann-La Roche Ag | Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2 |
CN107743491B (zh) * | 2015-05-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物 |
CN105541738B (zh) * | 2016-01-21 | 2018-04-06 | 西北师范大学 | 一种三氮唑取代的苯乙酮类化合物的制备方法 |
EP3475280B1 (en) * | 2016-06-23 | 2020-04-08 | H. Hoffnabb-La Roche Ag | Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives |
JP7090036B2 (ja) | 2016-06-23 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | 新規な[1,2,3]トリアゾロ[4,5-d]ピリミジン誘導体 |
JP6964099B2 (ja) | 2016-06-23 | 2021-11-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規[1,2,3]トリアゾロ[4,5−d]ピリミジン誘導体 |
WO2017220517A1 (en) * | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor |
AU2019324127A1 (en) * | 2018-08-20 | 2021-04-08 | Bessor Pharma, Llc | Applications of known and novel cannabinoids |
CN113874377A (zh) | 2019-05-13 | 2021-12-31 | 埃科莱布美国股份有限公司 | 作为铜腐蚀抑制剂的1,2,4-三唑并[1,5-a]嘧啶衍生物 |
US11447479B2 (en) | 2019-12-20 | 2022-09-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
MX2022012260A (es) | 2020-03-31 | 2022-11-30 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
AU2021249530A1 (en) | 2020-03-31 | 2022-12-01 | Nuevolution A/S | Compounds active towards nuclear receptors |
US20230279006A1 (en) * | 2020-07-08 | 2023-09-07 | Klotho Therapeutics, Inc. | Novel compounds and methods for increasing klotho gene expression |
MX2023005713A (es) | 2020-11-23 | 2023-05-30 | Hoffmann La Roche | Nuevo proceso para la elaboracion de derivados de tetrazol. |
AR127456A1 (es) | 2021-10-28 | 2024-01-24 | Hoffmann La Roche | Sintesis de [1,2,3]triazol[4,5-d]pirimidinas |
WO2023237460A1 (en) | 2022-06-07 | 2023-12-14 | F. Hoffmann-La Roche Ag | A process for preparing 1-[5-tert-butyl-3-[(1-methyltetrazol-5 -yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol |
WO2024047078A1 (en) * | 2022-09-01 | 2024-03-07 | F. Hoffmann-La Roche Ag | Dosage regimen of vicasinabin |
WO2024047079A1 (en) | 2022-09-01 | 2024-03-07 | F. Hoffmann-La Roche Ag | Anti-cb2 antibodies and their use in a flow cytometry assay to measure cell surface cb2 expression |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4076711A (en) * | 1976-04-05 | 1978-02-28 | Schering Corporation | Triazolo [4,5-d]-pyrimidines |
US5204353A (en) * | 1987-04-07 | 1993-04-20 | Ciba-Geigy Corporation | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith |
AU692484B2 (en) * | 1993-10-12 | 1998-06-11 | Du Pont Pharmaceuticals Company | 1N-alkyl-N-arylpyrimidinamines and derivatives thereof |
JP3398152B2 (ja) * | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | 1n−アルキル−n−アリールピリミジンアミンおよびその誘導体 |
CN101631789A (zh) | 2006-12-14 | 2010-01-20 | 百时美施贵宝公司 | 作为大麻素受体调节剂的氮杂双环杂环 |
US7655685B2 (en) | 2007-11-02 | 2010-02-02 | Jenrin Discovery, Inc. | Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes |
CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
JP2011515343A (ja) * | 2008-03-03 | 2011-05-19 | タイガー ファーマテック | チロシンキナーゼ阻害薬 |
AR080711A1 (es) | 2010-03-31 | 2012-05-02 | Lilly Co Eli | Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor |
UA111640C2 (uk) * | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
US9067943B2 (en) * | 2011-11-25 | 2015-06-30 | Hoffmann-La Roche Inc. | [1,2,3]triazolo[4,5-D]pyrimidine derivatives |
-
2012
- 2012-05-11 UA UAA201406094A patent/UA111640C2/uk unknown
- 2012-11-05 PL PL12780208T patent/PL2776442T3/pl unknown
- 2012-11-05 JP JP2014540410A patent/JP6138141B2/ja active Active
- 2012-11-05 WO PCT/EP2012/071788 patent/WO2013068306A1/en active Application Filing
- 2012-11-05 MX MX2014005184A patent/MX342309B/es active IP Right Grant
- 2012-11-05 EA EA201490912A patent/EA023581B1/ru unknown
- 2012-11-05 EP EP12780208.0A patent/EP2776442B1/en active Active
- 2012-11-05 ES ES12780208T patent/ES2553704T3/es active Active
- 2012-11-05 SG SG11201402197UA patent/SG11201402197UA/en unknown
- 2012-11-05 HU HUE12780208A patent/HUE025543T2/en unknown
- 2012-11-05 BR BR112014011055-7A patent/BR112014011055B1/pt active IP Right Grant
- 2012-11-05 PT PT127802080T patent/PT2776442E/pt unknown
- 2012-11-05 CN CN201280054639.7A patent/CN103930426B/zh active Active
- 2012-11-05 SI SI201230368T patent/SI2776442T1/sl unknown
- 2012-11-05 AU AU2012334173A patent/AU2012334173B2/en active Active
- 2012-11-05 DK DK12780208.0T patent/DK2776442T3/en active
- 2012-11-05 CA CA2850458A patent/CA2850458C/en active Active
- 2012-11-05 PE PE2014000649A patent/PE20141588A1/es active IP Right Grant
- 2012-11-05 KR KR1020147015045A patent/KR102032337B1/ko active IP Right Grant
- 2012-11-05 MY MYPI2014701156A patent/MY170878A/en unknown
- 2012-11-05 RS RS20150807A patent/RS54436B1/en unknown
- 2012-11-06 AR ARP120104159A patent/AR088663A1/es active IP Right Grant
- 2012-11-06 US US13/669,610 patent/US8741906B2/en active Active
- 2012-11-07 TW TW106134768A patent/TWI704150B/zh active
- 2012-11-07 TW TW101141431A patent/TWI639600B/zh active
-
2014
- 2014-03-28 CO CO14067070A patent/CO6920295A2/es active IP Right Grant
- 2014-04-03 IL IL231949A patent/IL231949A/en active IP Right Grant
- 2014-04-11 US US14/250,781 patent/US9056866B2/en active Active
- 2014-04-22 ZA ZA2014/02905A patent/ZA201402905B/en unknown
- 2014-05-06 CL CL2014001174A patent/CL2014001174A1/es unknown
- 2014-08-06 HK HK14108045.2A patent/HK1194732A1/zh unknown
-
2016
- 2016-01-15 HR HRP20160052TT patent/HRP20160052T1/hr unknown
- 2016-01-19 CY CY20161100050T patent/CY1117147T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA111640C2 (uk) | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 | |
MX346248B (es) | Derivados de [1,2,3]triazol[4,5-d]pirimidina como agonistas de los agonistas del receptor canabinoide 2. | |
EA201391239A1 (ru) | Пирроло[2,3-d]пиримидиновые производные в качестве ингибиторов тропомиозин-связанных киназ | |
EA201590224A1 (ru) | Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
EA201401351A1 (ru) | Производные бензимидазол-пролина | |
MX2016006336A (es) | Compuestos pirazolopirimidina. | |
AU2012213775A8 (en) | 7-azaindole derivatives | |
ATE483707T1 (de) | 2-cyclopropylthiazolderivate | |
TR201900662T4 (tr) | Cb2 reseptör antagonistleri olarak triazolo[4,5-d]pirimidin türevleri. | |
EA201500628A1 (ru) | Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов | |
EA201490596A1 (ru) | Новые производные дигидрохинолин-2-она | |
PH12015502409B1 (en) | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists | |
PH12014501415A1 (en) | Heterocyclic amide derivatives as p2x7 receptor antagonists | |
UA115357C2 (uk) | Похідні піридин-4-ілу | |
MX2013006418A (es) | Derivados de oxazolil-metileter como agonistas del receptor de alx. | |
EA201370149A1 (ru) | Антагонисты рецептора | |
EA201790939A1 (ru) | ТРИАЗОЛО[4,5-d]ПИРИМИДИНЫ В КАЧЕСТВЕ АГОНИСТОВ КАННАБИНОИДНЫХ РЕЦЕПТОРОВ ТИПА 2 | |
EA201590823A1 (ru) | 6-((s)-1-{1-[5-(2-гидроксиэтокси)пиридин-2-ил]-1h-пиразол-3-ил}этил)-3h-1,3-бензотиазол-2-он в качестве антагониста tarp-гамма 8-зависимого ampa-рецептора | |
PH12015501146A1 (en) | Hydantoin derivative | |
UA109804C2 (xx) | 2-метоксипіридин-4-ільні похідні | |
WO2012154879A3 (en) | Autophagy inhibitors | |
MX341132B (es) | Compuesto (tieno [2-3-b] [1,5] benzoxazepin-4-il) piperazin-1-ilo como agonista h1 inversos/antagonistas 5-ht2a de actividad doble. | |
MY162945A (en) | Azole derivative | |
UA112586C2 (uk) | Похідні бензімідазолпроліну | |
UA96048C2 (uk) | Застосування антагоніста рецепторів інтерлейкіна-1 як засобу фригопротекторної дії |