BR112015024272A2 - novos derivados de piridina - Google Patents

novos derivados de piridina

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Publication number
BR112015024272A2
BR112015024272A2 BR112015024272A BR112015024272A BR112015024272A2 BR 112015024272 A2 BR112015024272 A2 BR 112015024272A2 BR 112015024272 A BR112015024272 A BR 112015024272A BR 112015024272 A BR112015024272 A BR 112015024272A BR 112015024272 A2 BR112015024272 A2 BR 112015024272A2
Authority
BR
Brazil
Prior art keywords
pyridine derivatives
new pyridine
new
compound
formula
Prior art date
Application number
BR112015024272A
Other languages
English (en)
Inventor
Kimbara Atsushi
Rombach Didier
Rogers-Evans Mark
Nettekoven Matthias
Gavelle Olivier
Roever Stephan
Schulz-Gasch Tanja
Grether Uwe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015024272A2 publication Critical patent/BR112015024272A2/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/00Drugs for disorders of the urinary system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00Drugs for disorders of the senses
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
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Abstract

1/1 resumo novos derivados de piridina a invenção refere-se a um composto da fórmula (i) 3 r r2r41 r na (i) em que a e r1 a r4 são tais como se encontram definidos na descrição e nas reivindicações. o composto da fórmula (i) pode ser usado na forma de um medicamento.
BR112015024272A 2013-03-26 2014-03-24 novos derivados de piridina BR112015024272A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13161176 2013-03-26
PCT/EP2014/055797 WO2014154612A1 (en) 2013-03-26 2014-03-24 Novel pyridine derivatives

Publications (1)

Publication Number Publication Date
BR112015024272A2 true BR112015024272A2 (pt) 2017-07-18

Family

ID=47913322

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015024272A BR112015024272A2 (pt) 2013-03-26 2014-03-24 novos derivados de piridina

Country Status (34)

Country Link
US (2) US10308659B2 (pt)
EP (1) EP2978755B1 (pt)
JP (1) JP6500010B2 (pt)
KR (1) KR20150135458A (pt)
CN (1) CN105121436B (pt)
AR (1) AR095721A1 (pt)
AU (1) AU2014243190B2 (pt)
BR (1) BR112015024272A2 (pt)
CA (1) CA2899168A1 (pt)
CL (1) CL2015002835A1 (pt)
CR (1) CR20150440A (pt)
DK (1) DK2978755T3 (pt)
EA (1) EA027569B1 (pt)
ES (1) ES2661737T3 (pt)
HK (1) HK1211938A1 (pt)
HR (1) HRP20180371T1 (pt)
HU (1) HUE036934T2 (pt)
IL (1) IL240496B (pt)
LT (1) LT2978755T (pt)
MA (1) MA38404B1 (pt)
MX (1) MX365921B (pt)
MY (1) MY174000A (pt)
NO (1) NO2978755T3 (pt)
PE (1) PE20151559A1 (pt)
PH (1) PH12015501933A1 (pt)
PL (1) PL2978755T3 (pt)
PT (1) PT2978755T (pt)
RS (1) RS56927B1 (pt)
SG (1) SG11201507994QA (pt)
SI (1) SI2978755T1 (pt)
TW (1) TWI628174B (pt)
UA (1) UA116239C2 (pt)
WO (1) WO2014154612A1 (pt)
ZA (1) ZA201505251B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708341B2 (en) * 2014-06-09 2017-07-18 Sumitomo Chemical Company, Limited Method for producing pyridine compound
CR20180298A (es) * 2015-12-09 2018-07-18 Hoffmann La Roche Nuevos derivados de fenilo
PL3481201T3 (pl) * 2016-07-07 2021-03-22 Corteva Agriscience Llc Sposoby wytwarzania 4-alkoksy-3-(acylo lub alkilo)oksypikolinamidów
TW202334101A (zh) * 2017-04-06 2023-09-01 美商富曼西公司 殺真菌之噁二唑
EP3642200B1 (en) 2017-06-20 2023-05-03 F. Hoffmann-La Roche AG Pyridine derivatives
WO2019003956A1 (ja) * 2017-06-27 2019-01-03 住友化学株式会社 オキサジアゾール化合物及びその用途
CN108774220B (zh) * 2018-05-27 2019-04-23 西安培华学院 用于治疗心肌缺血的化合物及其应用
CN112638430B (zh) 2018-06-27 2023-05-16 豪夫迈·罗氏有限公司 放射性标记的大麻素受体2配体
WO2020002270A1 (en) 2018-06-27 2020-01-02 F. Hoffmann-La Roche Ag Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
PE20210368A1 (es) 2018-06-27 2021-02-26 Eth Zuerich Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2
CN114195759B (zh) * 2021-08-26 2023-10-20 上海零诺生物科技有限公司 一种2-甲基-5-(1-甲基吡咯烷-2-基)吡啶制备方法
EP4419508A2 (en) * 2021-10-22 2024-08-28 Carmot Therapeutics, Inc. Oxazole, oxadiazole, and indole derivatives for the inhibition of usp28
CN115073366B (zh) * 2022-06-08 2024-08-09 都创(重庆)医药科技有限公司 一种基于微通道技术快速制备3-氯吡啶-2-甲酸的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2479744A1 (en) * 2002-03-28 2003-10-09 Paul E. Finke Substituted 2,3-diphenyl pyridines
JP5406716B2 (ja) * 2006-08-07 2014-02-05 アイアンウッド ファーマシューティカルズ インコーポレイテッド インドール化合物
US20100227845A1 (en) * 2007-10-18 2010-09-09 Zhicai Wu Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
US9321727B2 (en) 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
UA111640C2 (uk) 2011-11-08 2016-05-25 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2
EP2870139B1 (en) 2012-07-04 2016-06-15 F.Hoffmann-La Roche Ag Novel adamantyl derivatives as cannabinoid receptor 2 agonists
MX2015007155A (es) 2012-12-07 2015-10-14 Hoffmann La Roche Nuevos derivados de piridina.
PE20151089A1 (es) 2012-12-07 2015-08-06 Hoffmann La Roche Piridin-2-amidas utiles como agonistas de cb2
MX2015007156A (es) 2012-12-07 2015-10-14 Hoffmann La Roche Piridina-2-amidas utiles como agonistas receptores de canabinoides 2 (cb2).
IN2015DN03145A (pt) 2012-12-07 2015-10-02 Hoffmann La Roche
PL2964646T3 (pl) 2013-03-07 2017-09-29 F.Hoffmann-La Roche Ag Nowe pochodne pirazolu
PE20161370A1 (es) 2014-04-04 2016-12-17 Hoffmann La Roche Nuevos derivados de piridina utiles como antagonistas de cb2
AR099932A1 (es) 2014-04-04 2016-08-31 Hoffmann La Roche Derivados de piridina

Also Published As

Publication number Publication date
HRP20180371T1 (hr) 2018-04-06
TW201518287A (zh) 2015-05-16
AU2014243190A1 (en) 2015-07-30
IL240496A0 (en) 2015-09-24
MA38404A1 (fr) 2017-01-31
ZA201505251B (en) 2016-07-27
MA38404B1 (fr) 2017-09-29
DK2978755T3 (en) 2018-03-05
PH12015501933B1 (en) 2016-01-11
UA116239C2 (uk) 2018-02-26
US20190248803A1 (en) 2019-08-15
US10308659B2 (en) 2019-06-04
CA2899168A1 (en) 2014-10-02
AR095721A1 (es) 2015-11-04
ES2661737T3 (es) 2018-04-03
US20160016968A1 (en) 2016-01-21
JP6500010B2 (ja) 2019-04-10
CN105121436A (zh) 2015-12-02
MY174000A (en) 2020-03-03
PH12015501933A1 (en) 2016-01-11
HK1211938A1 (en) 2016-06-03
PE20151559A1 (es) 2015-11-05
EA027569B1 (ru) 2017-08-31
IL240496B (en) 2019-03-31
EP2978755A1 (en) 2016-02-03
JP2016516737A (ja) 2016-06-09
PT2978755T (pt) 2018-02-26
WO2014154612A1 (en) 2014-10-02
EP2978755B1 (en) 2018-01-03
PL2978755T3 (pl) 2018-05-30
SG11201507994QA (en) 2015-10-29
HUE036934T2 (hu) 2018-08-28
SI2978755T1 (en) 2018-03-30
MX2015013629A (es) 2016-02-18
KR20150135458A (ko) 2015-12-02
MX365921B (es) 2019-06-20
CN105121436B (zh) 2018-07-27
NO2978755T3 (pt) 2018-06-02
RS56927B1 (sr) 2018-05-31
EA201591567A1 (ru) 2016-01-29
CL2015002835A1 (es) 2016-05-20
TWI628174B (zh) 2018-07-01
AU2014243190B2 (en) 2018-07-19
LT2978755T (lt) 2018-03-12
CR20150440A (es) 2015-10-08

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