BR112015024272A2 - novos derivados de piridina - Google Patents

novos derivados de piridina

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Publication number
BR112015024272A2
BR112015024272A2 BR112015024272A BR112015024272A BR112015024272A2 BR 112015024272 A2 BR112015024272 A2 BR 112015024272A2 BR 112015024272 A BR112015024272 A BR 112015024272A BR 112015024272 A BR112015024272 A BR 112015024272A BR 112015024272 A2 BR112015024272 A2 BR 112015024272A2
Authority
BR
Brazil
Prior art keywords
pyridine derivatives
new pyridine
new
compound
formula
Prior art date
Application number
BR112015024272A
Other languages
English (en)
Inventor
Kimbara Atsushi
Rombach Didier
Rogers-Evans Mark
Nettekoven Matthias
Gavelle Olivier
Roever Stephan
Schulz-Gasch Tanja
Grether Uwe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015024272A2 publication Critical patent/BR112015024272A2/pt

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    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/00Drugs for disorders of the urinary system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

1/1 resumo novos derivados de piridina a invenção refere-se a um composto da fórmula (i) 3 r r2r41 r na (i) em que a e r1 a r4 são tais como se encontram definidos na descrição e nas reivindicações. o composto da fórmula (i) pode ser usado na forma de um medicamento.
BR112015024272A 2013-03-26 2014-03-24 novos derivados de piridina BR112015024272A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13161176 2013-03-26
PCT/EP2014/055797 WO2014154612A1 (en) 2013-03-26 2014-03-24 Novel pyridine derivatives

Publications (1)

Publication Number Publication Date
BR112015024272A2 true BR112015024272A2 (pt) 2017-07-18

Family

ID=47913322

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015024272A BR112015024272A2 (pt) 2013-03-26 2014-03-24 novos derivados de piridina

Country Status (34)

Country Link
US (2) US10308659B2 (pt)
EP (1) EP2978755B1 (pt)
JP (1) JP6500010B2 (pt)
KR (1) KR20150135458A (pt)
CN (1) CN105121436B (pt)
AR (1) AR095721A1 (pt)
AU (1) AU2014243190B2 (pt)
BR (1) BR112015024272A2 (pt)
CA (1) CA2899168A1 (pt)
CL (1) CL2015002835A1 (pt)
CR (1) CR20150440A (pt)
DK (1) DK2978755T3 (pt)
EA (1) EA027569B1 (pt)
ES (1) ES2661737T3 (pt)
HK (1) HK1211938A1 (pt)
HR (1) HRP20180371T1 (pt)
HU (1) HUE036934T2 (pt)
IL (1) IL240496B (pt)
LT (1) LT2978755T (pt)
MA (1) MA38404B1 (pt)
MX (1) MX365921B (pt)
MY (1) MY174000A (pt)
NO (1) NO2978755T3 (pt)
PE (1) PE20151559A1 (pt)
PH (1) PH12015501933B1 (pt)
PL (1) PL2978755T3 (pt)
PT (1) PT2978755T (pt)
RS (1) RS56927B1 (pt)
SG (1) SG11201507994QA (pt)
SI (1) SI2978755T1 (pt)
TW (1) TWI628174B (pt)
UA (1) UA116239C2 (pt)
WO (1) WO2014154612A1 (pt)
ZA (1) ZA201505251B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2015190316A1 (ja) * 2014-06-09 2017-04-20 住友化学株式会社 ピリジン化合物の製造方法
SI3386951T1 (sl) 2015-12-09 2020-07-31 F. Hoffmann-La Roche Ag Fenilni derivati kot agonisti kanabinoidnega receptorja 2
CN109640657B (zh) * 2016-07-07 2020-10-30 美国陶氏益农公司 制备4-烷氧基-3-(酰基或脂族饱和烃基)氧基吡啶甲酰胺的方法
TWI829634B (zh) 2017-04-06 2024-01-21 美商富曼西公司 殺真菌之噁二唑
CN110753690B (zh) * 2017-06-20 2023-12-05 豪夫迈·罗氏有限公司 吡啶衍生物
WO2019003956A1 (ja) * 2017-06-27 2019-01-03 住友化学株式会社 オキサジアゾール化合物及びその用途
CN108774220B (zh) * 2018-05-27 2019-04-23 西安培华学院 用于治疗心肌缺血的化合物及其应用
EP3814337A1 (en) 2018-06-27 2021-05-05 F. Hoffmann-La Roche AG Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
CN114195759B (zh) * 2021-08-26 2023-10-20 上海零诺生物科技有限公司 一种2-甲基-5-(1-甲基吡咯烷-2-基)吡啶制备方法
WO2023069721A2 (en) * 2021-10-22 2023-04-27 Carmot Therapeutics, Inc. Oxazole, oxadiazole, and indole derivatives for the inhibition of usp28
CN115073366A (zh) * 2022-06-08 2022-09-20 都创(重庆)医药科技有限公司 一种基于微通道技术快速制备3-氯吡啶-2-甲酸的方法

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WO2003082191A2 (en) * 2002-03-28 2003-10-09 Merck & Co., Inc. Substituted 2,3-diphenyl pyridines
EP2610244A1 (en) 2006-08-07 2013-07-03 Ironwood Pharmaceuticals, Inc. Indole compounds
WO2009051705A1 (en) * 2007-10-18 2009-04-23 Merck & Co., Inc. Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
US9321727B2 (en) * 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
UA111640C2 (uk) 2011-11-08 2016-05-25 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2
WO2014005968A1 (en) 2012-07-04 2014-01-09 F. Hoffmann-La Roche Ag Novel adamantyl derivatives as cannabinoid receptor 2 agonists
SI2928882T1 (sl) 2012-12-07 2017-05-31 F. Hoffmann-La Roche Ag Pirazinski derivati kot agonisti receptorja CB2
WO2014086805A1 (en) 2012-12-07 2014-06-12 F. Hoffmann-La Roche Ag Pyridine-2-amides useful as cb2 agonists
JP6426618B2 (ja) 2012-12-07 2018-11-21 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 新規なピリジン誘導体
BR112015009600A2 (pt) 2012-12-07 2017-07-04 Hoffmann La Roche piridina-2-amidas úteis como agonistas cb2
KR102369407B1 (ko) 2013-03-07 2022-03-02 에프. 호프만-라 로슈 아게 신규 피라졸 유도체
AR099933A1 (es) 2014-04-04 2016-08-31 Hoffmann La Roche Derivados heterocíclicos de piridina agonistas de cb2
EA030032B1 (ru) 2014-04-04 2018-06-29 Ф. Хоффманн-Ля Рош Аг 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов

Also Published As

Publication number Publication date
LT2978755T (lt) 2018-03-12
TW201518287A (zh) 2015-05-16
PT2978755T (pt) 2018-02-26
NO2978755T3 (pt) 2018-06-02
WO2014154612A1 (en) 2014-10-02
IL240496A0 (en) 2015-09-24
TWI628174B (zh) 2018-07-01
SI2978755T1 (en) 2018-03-30
US20190248803A1 (en) 2019-08-15
RS56927B1 (sr) 2018-05-31
ZA201505251B (en) 2016-07-27
HK1211938A1 (en) 2016-06-03
PH12015501933A1 (en) 2016-01-11
CN105121436A (zh) 2015-12-02
CN105121436B (zh) 2018-07-27
HUE036934T2 (hu) 2018-08-28
MA38404B1 (fr) 2017-09-29
CA2899168A1 (en) 2014-10-02
SG11201507994QA (en) 2015-10-29
CL2015002835A1 (es) 2016-05-20
MX365921B (es) 2019-06-20
HRP20180371T1 (hr) 2018-04-06
EP2978755A1 (en) 2016-02-03
IL240496B (en) 2019-03-31
MX2015013629A (es) 2016-02-18
PH12015501933B1 (en) 2016-01-11
UA116239C2 (uk) 2018-02-26
KR20150135458A (ko) 2015-12-02
PE20151559A1 (es) 2015-11-05
EA201591567A1 (ru) 2016-01-29
CR20150440A (es) 2015-10-08
US20160016968A1 (en) 2016-01-21
AR095721A1 (es) 2015-11-04
US10308659B2 (en) 2019-06-04
AU2014243190B2 (en) 2018-07-19
MA38404A1 (fr) 2017-01-31
EA027569B1 (ru) 2017-08-31
JP2016516737A (ja) 2016-06-09
DK2978755T3 (en) 2018-03-05
EP2978755B1 (en) 2018-01-03
AU2014243190A1 (en) 2015-07-30
ES2661737T3 (es) 2018-04-03
JP6500010B2 (ja) 2019-04-10
MY174000A (en) 2020-03-03
PL2978755T3 (pl) 2018-05-30

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