CR20180298A - Nuevos derivados de fenilo - Google Patents
Nuevos derivados de feniloInfo
- Publication number
- CR20180298A CR20180298A CR20180298A CR20180298A CR20180298A CR 20180298 A CR20180298 A CR 20180298A CR 20180298 A CR20180298 A CR 20180298A CR 20180298 A CR20180298 A CR 20180298A CR 20180298 A CR20180298 A CR 20180298A
- Authority
- CR
- Costa Rica
- Prior art keywords
- phenyl
- new derivatives
- compound
- formula
- derivatives
- Prior art date
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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Abstract
La invención se refiere a un compuesto de la fórmula (I): en la que de R1 a R3 tienen los significados definidos en la descripción y en las reivindicaciones. El compuesto de la fórmula (I) puede emplearse como medicamento
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EP15198733 | 2015-12-09 | ||
PCT/EP2016/079825 WO2017097732A1 (en) | 2015-12-09 | 2016-12-06 | Phenyl derivatives as cannabinoid receptor 2 agonists |
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KR100929376B1 (ko) * | 2009-01-21 | 2009-12-02 | (주)둔포기계 | 스퍼터링 장치 |
BR112018011562B1 (pt) * | 2015-12-09 | 2023-05-02 | F. Hoffmann-La Roche Ag | Novos derivados de fenil |
TW201904943A (zh) | 2017-06-20 | 2019-02-01 | 瑞士商赫孚孟拉羅股份公司 | 新穎吡啶衍生物 |
EP3814337A1 (en) | 2018-06-27 | 2021-05-05 | F. Hoffmann-La Roche AG | Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists |
JP7445610B2 (ja) | 2018-06-27 | 2024-03-07 | エフ. ホフマン-ラ ロシュ アーゲー | 医療に有用な新規化合物 |
WO2020002314A1 (en) | 2018-06-27 | 2020-01-02 | F. Hoffmann-La Roche Ag | Radiolabeled cannabinoid receptor 2 ligand |
NO345530B1 (en) * | 2020-03-20 | 2021-03-29 | Axichem As | Synthesis of capsaicin derivatives |
JPWO2023136263A1 (es) | 2022-01-12 | 2023-07-20 |
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DE10102322A1 (de) | 2001-01-19 | 2002-07-25 | Merck Patent Gmbh | Phenylderivate |
TW200745096A (en) * | 2005-08-23 | 2007-12-16 | Organon Nv | Indole derivatives |
RU2425832C2 (ru) * | 2006-04-03 | 2011-08-10 | Астеллас Фарма Инк. | Гетеросоединение |
BRPI0709866B8 (pt) | 2006-04-03 | 2021-05-25 | Astellas Pharma Inc | compostos héteros e composição farmacêutica compreendendo ditos compostos |
US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
US9403808B2 (en) * | 2011-10-28 | 2016-08-02 | Hoffmann-La Roche Inc. | Pyrazine derivatives |
MA38239A1 (fr) * | 2012-12-07 | 2017-03-31 | Hoffmann La Roche | Nouveaux dérivés de pyridine |
SG11201504122YA (en) | 2012-12-07 | 2015-06-29 | Hoffmann La Roche | Pyridine-2-amides useful as cb2 agonists |
HUE030836T2 (en) * | 2012-12-07 | 2017-06-28 | Hoffmann La Roche | Pyrazine Derivatives As CB2 Receptor Agonists |
JP6280132B2 (ja) | 2012-12-07 | 2018-02-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Cb2アゴニストとして有用なピリジン−2−アミド |
PL2978755T3 (pl) * | 2013-03-26 | 2018-05-30 | Hoffmann La Roche | Nowe pochodne pirydyny |
MX2016012690A (es) | 2014-04-04 | 2017-04-27 | Hoffmann La Roche | Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide. |
MA39843A (fr) * | 2014-04-04 | 2017-02-08 | Hoffmann La Roche | Pyridine-2-amides utiles comme agonistes de cb2 |
CN204999979U (zh) * | 2015-08-05 | 2016-01-27 | 林信涌 | 电解装置 |
BR112018011562B1 (pt) * | 2015-12-09 | 2023-05-02 | F. Hoffmann-La Roche Ag | Novos derivados de fenil |
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