MA38239A1 - Nouveaux dérivés de pyridine - Google Patents
Nouveaux dérivés de pyridineInfo
- Publication number
- MA38239A1 MA38239A1 MA38239A MA38239A MA38239A1 MA 38239 A1 MA38239 A1 MA 38239A1 MA 38239 A MA38239 A MA 38239A MA 38239 A MA38239 A MA 38239A MA 38239 A1 MA38239 A1 MA 38239A1
- Authority
- MA
- Morocco
- Prior art keywords
- pyridine derivatives
- new pyridine
- new
- compound
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La présente invention concerne un composé de formule (i) où r1 à r3 sont tels que définis dans la description et les revendications. Le composé de formule (i) peut être utilisé comme médicament.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12196022 | 2012-12-07 | ||
PCT/EP2013/075225 WO2014086705A1 (fr) | 2012-12-07 | 2013-12-02 | Nouveaux dérivés de pyridine |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38239A1 true MA38239A1 (fr) | 2017-03-31 |
Family
ID=47290804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38239A MA38239A1 (fr) | 2012-12-07 | 2013-12-02 | Nouveaux dérivés de pyridine |
Country Status (34)
Country | Link |
---|---|
US (1) | US9522886B2 (fr) |
EP (2) | EP3357918A1 (fr) |
JP (1) | JP6426618B2 (fr) |
KR (1) | KR20150092282A (fr) |
CN (2) | CN104837831B (fr) |
AR (1) | AR093843A1 (fr) |
AU (2) | AU2013354278B2 (fr) |
BR (1) | BR112015012919A2 (fr) |
CA (1) | CA2890100A1 (fr) |
CL (1) | CL2015001536A1 (fr) |
CO (1) | CO7350620A2 (fr) |
CR (1) | CR20150250A (fr) |
DK (1) | DK2928881T3 (fr) |
EA (1) | EA026669B1 (fr) |
ES (1) | ES2668690T3 (fr) |
HK (1) | HK1208031A1 (fr) |
HR (1) | HRP20180672T1 (fr) |
HU (1) | HUE036911T2 (fr) |
IL (1) | IL239075B (fr) |
LT (1) | LT2928881T (fr) |
MA (1) | MA38239A1 (fr) |
MX (1) | MX2015007155A (fr) |
NO (1) | NO2928881T3 (fr) |
PE (1) | PE20151025A1 (fr) |
PH (1) | PH12015501083A1 (fr) |
PL (1) | PL2928881T3 (fr) |
PT (1) | PT2928881T (fr) |
RS (1) | RS57143B1 (fr) |
SG (2) | SG11201504416XA (fr) |
SI (1) | SI2928881T1 (fr) |
TW (1) | TWI600645B (fr) |
UA (1) | UA114656C2 (fr) |
WO (1) | WO2014086705A1 (fr) |
ZA (1) | ZA201503969B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014135507A1 (fr) | 2013-03-07 | 2014-09-12 | F. Hoffmann-La Roche Ag | Nouveaux dérivés de pyrazole |
UA116239C2 (uk) | 2013-03-26 | 2018-02-26 | Ф. Хоффманн-Ля Рош Аг | Нові похідні піридину |
CA2903588C (fr) | 2013-05-02 | 2021-10-26 | F. Hoffmann-La Roche Ag | Derives de la purine en tant qu'agonistes du recepteur cb2 |
RS56313B1 (sr) | 2013-05-02 | 2017-12-29 | Hoffmann La Roche | Derivati pirolo[2,3-d]pirimidina kao agonisti cb2 receptora |
LT3483163T (lt) | 2013-09-06 | 2021-09-10 | F. Hoffmann-La Roche Ag | Triazol[4,5-d]pirimidino dariniai kaip cb2 receptorių antagonistai |
WO2015150438A1 (fr) * | 2014-04-04 | 2015-10-08 | F. Hoffmann-La Roche Ag | Pyridine-2-carboxamides bisubstitués en 5,6 servant d'agonistes du récepteur cannabinoïde |
US10214508B2 (en) | 2014-06-13 | 2019-02-26 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
PL3386951T3 (pl) * | 2015-12-09 | 2020-06-29 | F. Hoffmann-La Roche Ag | Pochodne fenylowe jako agoniści receptora kannabinoidowego typu 2 |
WO2017107089A1 (fr) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | Modulateurs allostériques 3-(1h-pyrazol-4-yl)pyridine du récepteur muscarinique m4 de l'acétylcholine |
JP7300398B2 (ja) | 2017-06-20 | 2023-06-29 | エフ. ホフマン-ラ ロシュ アーゲー | ピリジン誘導体 |
EP3781551A1 (fr) * | 2018-04-18 | 2021-02-24 | Basf Se | Monoester de d-glucaro-6,3-lactone et son procédé de préparation |
EP3813888A1 (fr) | 2018-06-27 | 2021-05-05 | F. Hoffmann-La Roche AG | Ligand du récepteur cannabinoïde 2 radiomarqué |
EP3814337A1 (fr) | 2018-06-27 | 2021-05-05 | F. Hoffmann-La Roche AG | Dérivés de pyridine et de pyrazine en tant qu'agonistes de cannabinoïde 2 préférentiels |
JP7478672B2 (ja) * | 2018-06-27 | 2024-05-07 | エフ. ホフマン-ラ ロシュ アーゲー | カンナビノイド受容体2の阻害剤としての新規なアゼチジン置換ピリジン及びピラジン化合物 |
CN114502538A (zh) * | 2019-09-30 | 2022-05-13 | 豪夫迈·罗氏有限公司 | 用于治疗和预防乙型肝炎病毒感染的经取代的3,4-二氢喹唑啉 |
EP4211171A2 (fr) | 2020-09-10 | 2023-07-19 | Precirix N.V. | Fragment d'anticorps contre fap |
CA3216874A1 (fr) * | 2021-04-19 | 2022-10-27 | Chemocentryx, Inc. | Azetidinyl-acetamides utilises comme inhibiteurs de cxcr7 |
WO2023203135A1 (fr) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Anticorps radiomarqué amélioré |
WO2023213801A1 (fr) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pré-ciblage |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2076499B1 (fr) | 2006-10-04 | 2010-05-12 | F.Hoffmann-La Roche Ag | Dérivés de pyrazine-2-carboxamide en tant que modulateurs du récepteur cb2 |
WO2012031817A1 (fr) | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Détermination des niveaux de protéine abca1 dans des cellules |
UY33874A (es) * | 2011-01-26 | 2012-08-31 | Sanofi Aventis | Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas |
US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
-
2013
- 2013-12-02 EP EP18154216.8A patent/EP3357918A1/fr not_active Withdrawn
- 2013-12-02 SI SI201331023T patent/SI2928881T1/en unknown
- 2013-12-02 UA UAA201506688A patent/UA114656C2/uk unknown
- 2013-12-02 DK DK13799520.5T patent/DK2928881T3/en active
- 2013-12-02 NO NO13799520A patent/NO2928881T3/no unknown
- 2013-12-02 EA EA201591064A patent/EA026669B1/ru not_active IP Right Cessation
- 2013-12-02 CN CN201380063475.9A patent/CN104837831B/zh not_active Expired - Fee Related
- 2013-12-02 MA MA38239A patent/MA38239A1/fr unknown
- 2013-12-02 MX MX2015007155A patent/MX2015007155A/es unknown
- 2013-12-02 RS RS20180493A patent/RS57143B1/sr unknown
- 2013-12-02 JP JP2015545757A patent/JP6426618B2/ja not_active Expired - Fee Related
- 2013-12-02 SG SG11201504416XA patent/SG11201504416XA/en unknown
- 2013-12-02 CA CA2890100A patent/CA2890100A1/fr not_active Abandoned
- 2013-12-02 US US14/648,431 patent/US9522886B2/en not_active Expired - Fee Related
- 2013-12-02 CN CN201710932324.2A patent/CN107674061A/zh active Pending
- 2013-12-02 KR KR1020157017889A patent/KR20150092282A/ko not_active Application Discontinuation
- 2013-12-02 LT LTEP13799520.5T patent/LT2928881T/lt unknown
- 2013-12-02 HU HUE13799520A patent/HUE036911T2/hu unknown
- 2013-12-02 PT PT137995205T patent/PT2928881T/pt unknown
- 2013-12-02 AU AU2013354278A patent/AU2013354278B2/en not_active Ceased
- 2013-12-02 SG SG10201800170YA patent/SG10201800170YA/en unknown
- 2013-12-02 BR BR112015012919A patent/BR112015012919A2/pt not_active Application Discontinuation
- 2013-12-02 ES ES13799520.5T patent/ES2668690T3/es active Active
- 2013-12-02 PE PE2015000744A patent/PE20151025A1/es not_active Application Discontinuation
- 2013-12-02 WO PCT/EP2013/075225 patent/WO2014086705A1/fr active Application Filing
- 2013-12-02 PL PL13799520T patent/PL2928881T3/pl unknown
- 2013-12-02 EP EP13799520.5A patent/EP2928881B1/fr not_active Not-in-force
- 2013-12-06 AR ARP130104545A patent/AR093843A1/es unknown
- 2013-12-06 TW TW102144952A patent/TWI600645B/zh not_active IP Right Cessation
-
2015
- 2015-04-29 CO CO15097806A patent/CO7350620A2/es unknown
- 2015-05-12 CR CR20150250A patent/CR20150250A/es unknown
- 2015-05-15 PH PH12015501083A patent/PH12015501083A1/en unknown
- 2015-05-28 IL IL239075A patent/IL239075B/en not_active IP Right Cessation
- 2015-06-03 ZA ZA2015/03969A patent/ZA201503969B/en unknown
- 2015-06-05 CL CL2015001536A patent/CL2015001536A1/es unknown
- 2015-09-08 HK HK15108719.6A patent/HK1208031A1/xx not_active IP Right Cessation
-
2017
- 2017-12-20 AU AU2017279648A patent/AU2017279648A1/en not_active Abandoned
-
2018
- 2018-04-26 HR HRP20180672TT patent/HRP20180672T1/hr unknown
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