MA39172A1 - Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines - Google Patents

Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines

Info

Publication number
MA39172A1
MA39172A1 MA39172A MA39172A MA39172A1 MA 39172 A1 MA39172 A1 MA 39172A1 MA 39172 A MA39172 A MA 39172A MA 39172 A MA39172 A MA 39172A MA 39172 A1 MA39172 A1 MA 39172A1
Authority
MA
Morocco
Prior art keywords
inhibitors
bromodomaine
bicyclic derivatives
heterocyclic bicyclic
heterocyclic
Prior art date
Application number
MA39172A
Other languages
English (en)
Other versions
MA39172B1 (fr
Inventor
Susanta Samajdar
Chandrasekhar Abbineni
Sanjita Sasmal
Subramanya Hosahalli
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of MA39172A1 publication Critical patent/MA39172A1/fr
Publication of MA39172B1 publication Critical patent/MA39172B1/fr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/5381,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La présente invention concerne des dérivés bicycliques hétérocycliques de formule (i), qui peuvent être thérapeutiquement utiles, plus particulièrement comme inhibiteurs de bromodomaines ; (i), dans laquelle r
MA39172A 2014-01-09 2015-01-06 Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines MA39172B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN125CH2014 2014-01-09
PCT/IB2015/050090 WO2015104653A1 (fr) 2014-01-09 2015-01-06 Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines

Publications (2)

Publication Number Publication Date
MA39172A1 true MA39172A1 (fr) 2018-04-30
MA39172B1 MA39172B1 (fr) 2018-10-31

Family

ID=52462967

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39172A MA39172B1 (fr) 2014-01-09 2015-01-06 Dérivés bicycliques hétérocycliques comme inhibiteurs de bromodomaines

Country Status (30)

Country Link
US (2) US10077259B2 (fr)
EP (1) EP3092227B1 (fr)
JP (1) JP6480944B2 (fr)
KR (1) KR102394518B1 (fr)
CN (1) CN106061966B (fr)
AU (1) AU2015205339B2 (fr)
BR (1) BR112016015311B1 (fr)
CA (1) CA2934788C (fr)
CL (1) CL2016001737A1 (fr)
CY (1) CY1122046T1 (fr)
DK (1) DK3092227T3 (fr)
EA (1) EA029224B1 (fr)
ES (1) ES2687497T3 (fr)
HR (1) HRP20181650T1 (fr)
HU (1) HUE041546T2 (fr)
IL (1) IL246140B (fr)
LT (1) LT3092227T (fr)
MA (1) MA39172B1 (fr)
MX (1) MX2016009052A (fr)
MY (1) MY190835A (fr)
PE (1) PE20161021A1 (fr)
PH (1) PH12016501355A1 (fr)
PL (1) PL3092227T3 (fr)
PT (1) PT3092227T (fr)
RS (1) RS57586B1 (fr)
SA (1) SA516371448B1 (fr)
SG (1) SG11201604916YA (fr)
SI (1) SI3092227T1 (fr)
UA (1) UA117165C2 (fr)
WO (1) WO2015104653A1 (fr)

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WO2015095492A1 (fr) 2013-12-19 2015-06-25 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs des protéines bet
SG11201608843TA (en) 2014-04-23 2016-11-29 Incyte Corp 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS
WO2016044130A1 (fr) 2014-09-15 2016-03-24 Incyte Corporation Hétérocycles tricycliques utilisés en tant qu'inhibiteurs des protéines bet
WO2017001733A1 (fr) * 2015-07-02 2017-01-05 Orion Corporation Dérivés d'hétérocycles bicycliques comme inhibiteurs de bromodomaines
KR20180039117A (ko) 2015-08-11 2018-04-17 네오메드 인스티튜트 아릴-치환된 디히드로퀴놀리논, 그의 제조법 및 제약으로서의 그의 용도
US10836742B2 (en) 2015-08-11 2020-11-17 Neomed Institute N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
EP3334719B1 (fr) 2015-08-12 2021-09-15 Neomed Institute Benzimidazoles substitués, préparation et utilisation de ceux-ci en tant qu'agents pharmaceutiques
WO2017066876A1 (fr) 2015-10-21 2017-04-27 Neomed Institute Imidazopyridines substituées, leur préparation et leur utilisation comme médicaments
US20170121347A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
CN105198871A (zh) * 2015-11-06 2015-12-30 中国药科大学 一类喹喔啉酮类化合物及其制备方法和用途
WO2017127930A1 (fr) 2016-01-28 2017-08-03 Neomed Institute [1,2,4]triazolo[4,3-a]pyridines substituées, leur préparation et leur utilisation comme médicaments
AU2017252276A1 (en) 2016-04-18 2018-11-15 Celgene Quanticel Research, Inc. Therapeutic compounds
DE102017005089A1 (de) 2016-05-30 2017-11-30 Bayer Pharma Aktiengesellschaft Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one
IL263824B2 (en) 2016-06-20 2023-10-01 Incyte Corp Crystals in solid form in the presence of an inhibitor
JP2020503312A (ja) 2016-12-22 2020-01-30 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 置換1,2,4−チアジアゾリルピロロンおよび1,2,4−チアジアゾリルヒダントイン、ならびにその塩、ならびにその除草剤としての使用
BR112019012567A2 (pt) 2016-12-22 2019-11-26 Bayer Ag azolilpirrolonas e azolil-hidantoínas substituídas e sais das mesmas e uso das mesmas como substâncias ativas herbicidas
WO2018161876A1 (fr) * 2017-03-08 2018-09-13 中国科学院上海药物研究所 Inhibiteur de protéine de reconnaissance de bromodomaine dihydroquinoxaline, son procédé de préparation et son utilisation
JP2020516672A (ja) 2017-04-18 2020-06-11 セルジーン クオンティセル リサーチ,インク. 治療用化合物
CN110092782B (zh) * 2018-01-30 2022-10-21 中国科学院广州生物医药与健康研究院 一种苯并六元氮杂环化合物及其制备方法和应用
CN110960528A (zh) * 2018-09-30 2020-04-07 四川大学 Ar和bet双重抑制剂及其用途
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CA3132934A1 (fr) 2019-04-11 2020-10-15 Eila Luukkonen Forme cristalline d'un inhibiteur bet et sa fabrication
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Also Published As

Publication number Publication date
BR112016015311A2 (fr) 2017-08-08
AU2015205339B2 (en) 2018-07-05
LT3092227T (lt) 2018-08-10
US20180339982A1 (en) 2018-11-29
CL2016001737A1 (es) 2017-02-03
PT3092227T (pt) 2018-10-24
KR102394518B1 (ko) 2022-05-06
UA117165C2 (uk) 2018-06-25
EA201691404A1 (ru) 2016-10-31
PH12016501355B1 (en) 2017-02-06
IL246140B (en) 2019-09-26
WO2015104653A1 (fr) 2015-07-16
HUE041546T2 (hu) 2019-05-28
PE20161021A1 (es) 2016-11-09
US10077259B2 (en) 2018-09-18
CN106061966A (zh) 2016-10-26
PH12016501355A1 (en) 2017-02-06
EA029224B1 (ru) 2018-02-28
HRP20181650T1 (hr) 2018-12-14
RS57586B1 (sr) 2018-11-30
SG11201604916YA (en) 2016-07-28
CY1122046T1 (el) 2020-07-31
SI3092227T1 (sl) 2018-10-30
EP3092227A1 (fr) 2016-11-16
JP6480944B2 (ja) 2019-03-13
CA2934788C (fr) 2021-12-07
IL246140A0 (en) 2016-08-02
CN106061966B (zh) 2018-12-07
DK3092227T3 (en) 2018-09-03
CA2934788A1 (fr) 2015-07-16
MA39172B1 (fr) 2018-10-31
US10590118B2 (en) 2020-03-17
BR112016015311B1 (pt) 2023-01-24
JP2017502057A (ja) 2017-01-19
PL3092227T3 (pl) 2018-12-31
KR20160106164A (ko) 2016-09-09
NZ721993A (en) 2021-05-28
ES2687497T3 (es) 2018-10-25
US20160368906A1 (en) 2016-12-22
SA516371448B1 (ar) 2018-10-15
AU2015205339A1 (en) 2016-07-07
MY190835A (en) 2022-05-12
MX2016009052A (es) 2016-09-09
EP3092227B1 (fr) 2018-07-11

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