MX2016012690A - Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide. - Google Patents

Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide.

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Publication number
MX2016012690A
MX2016012690A MX2016012690A MX2016012690A MX2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A MX 2016012690 A MX2016012690 A MX 2016012690A
Authority
MX
Mexico
Prior art keywords
carboxamides
cannabinoid receptor
receptor agonists
disubstituted pyridine
compound
Prior art date
Application number
MX2016012690A
Other languages
English (en)
Inventor
Nettekoven Matthias
Gobbi Luca
Grether Uwe
Roever Stephan
Rogers - Evans Mark
Slavik Roger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016012690A publication Critical patent/MX2016012690A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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  • Chemical & Material Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con un compuesto de la fórmula (I), en donde R1 a R4 se definen como en la descripción y en las reivindicaciones. El compuesto de la fórmula (I) son agonistas del Receptor Cannabinoide 2 y, por lo tanto, son útiles en el tratamiento de varias enfermedades, tal como dolor, aterosclerosis, inflamación, etcétera.
MX2016012690A 2014-04-04 2015-04-01 Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide. MX2016012690A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14163554 2014-04-04
PCT/EP2015/057144 WO2015150438A1 (en) 2014-04-04 2015-04-01 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists

Publications (1)

Publication Number Publication Date
MX2016012690A true MX2016012690A (es) 2017-04-27

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ID=50424142

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Application Number Title Priority Date Filing Date
MX2016012690A MX2016012690A (es) 2014-04-04 2015-04-01 Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide.

Country Status (18)

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US (2) US20160376237A1 (es)
EP (1) EP3126349B1 (es)
JP (1) JP6353072B2 (es)
KR (2) KR20180072827A (es)
CN (2) CN106458984A (es)
AR (1) AR099932A1 (es)
AU (1) AU2015239537B2 (es)
CA (1) CA2944256A1 (es)
CL (1) CL2016002389A1 (es)
CR (1) CR20160459A (es)
EA (1) EA030032B1 (es)
IL (1) IL247773A0 (es)
MX (1) MX2016012690A (es)
PE (1) PE20161407A1 (es)
PH (1) PH12016501849A1 (es)
SG (1) SG11201608246VA (es)
TW (1) TW201625538A (es)
WO (1) WO2015150438A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2661737T3 (es) 2013-03-26 2018-04-03 F. Hoffmann-La Roche Ag Derivados de piridina novedosos
PL3126354T3 (pl) 2014-04-04 2020-06-15 H. Lundbeck A/S Fluorowcowane chinazolino-THF-aminy jako inhibitory PDE1
MX2018006802A (es) 2015-12-09 2018-09-05 Hoffmann La Roche Derivados de fenilo como agonistas del receptor de canabinoides 2.
GB201703282D0 (en) * 2017-03-01 2017-04-12 Glaxosmithkline Intellectual Property (No 2) Ltd Compounds
CN110753690B (zh) 2017-06-20 2023-12-05 豪夫迈·罗氏有限公司 吡啶衍生物
PE20210368A1 (es) * 2018-06-27 2021-02-26 Eth Zuerich Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2
CN112119068A (zh) * 2018-06-27 2020-12-22 豪夫迈·罗氏有限公司 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物
JP7454512B2 (ja) 2018-06-27 2024-03-22 エフ． ホフマン－ラ ロシュ アーゲー 優先的カンナビノイド２アゴニストとしてのピリジン及びピラジン誘導体
JP7456948B2 (ja) 2018-06-27 2024-03-27 エフ． ホフマン－ラ ロシュ アーゲー 放射性標識カンナビノイド受容体２リガンド
WO2023145372A1 (ja) * 2022-01-28 2023-08-03 日本曹達株式会社 アミド化合物の製造方法
CN115160306B (zh) * 2022-08-04 2024-03-26 上海皓鸿生物医药科技有限公司 一种特力利汀中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101114704B1 (ko) * 2006-10-04 2012-03-14 에프. 호프만-라 로슈 아게 Ｃｂ2 수용체 조절제로서 피라진-2-카복스아마이드 유도체
WO2012031817A1 (en) * 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Determination of abca1 protein levels in cells
US9321727B2 (en) * 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
US9403808B2 (en) * 2011-10-28 2016-08-02 Hoffmann-La Roche Inc. Pyrazine derivatives
LT2928868T (lt) * 2012-12-07 2017-10-25 F. Hoffmann-La Roche Ag Piridin-2-amidai, tinkami naudoti kaip cb2 agonistai
KR20150092282A (ko) * 2012-12-07 2015-08-12 에프. 호프만-라 로슈 아게 신규한 피리딘 유도체

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KR20180072827A (ko) 2018-06-29
CN106458984A (zh) 2017-02-22
EP3126349A1 (en) 2017-02-08
CA2944256A1 (en) 2015-10-08
CN111170938A (zh) 2020-05-19
JP6353072B2 (ja) 2018-07-04
EA201691982A1 (ru) 2017-01-30
TW201625538A (zh) 2016-07-16
US20180327360A1 (en) 2018-11-15
AR099932A1 (es) 2016-08-31
SG11201608246VA (en) 2016-10-28
EP3126349B1 (en) 2019-06-26
EA030032B1 (ru) 2018-06-29
PH12016501849A1 (en) 2016-12-19
PE20161407A1 (es) 2016-12-28
CL2016002389A1 (es) 2017-03-17
AU2015239537B2 (en) 2019-04-04
IL247773A0 (en) 2016-11-30
WO2015150438A1 (en) 2015-10-08
CR20160459A (es) 2016-12-02
JP2017509688A (ja) 2017-04-06
US20160376237A1 (en) 2016-12-29
KR20160132495A (ko) 2016-11-18
AU2015239537A1 (en) 2016-11-17

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