EA201691982A1 - 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов - Google Patents

5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов

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Publication number
EA201691982A1
EA201691982A1 EA201691982A EA201691982A EA201691982A1 EA 201691982 A1 EA201691982 A1 EA 201691982A1 EA 201691982 A EA201691982 A EA 201691982A EA 201691982 A EA201691982 A EA 201691982A EA 201691982 A1 EA201691982 A1 EA 201691982A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carboxamides
agonists
disposable
pyridine
cannabinoid receptors
Prior art date
Application number
EA201691982A
Other languages
English (en)
Other versions
EA030032B1 (ru
Inventor
Лука ГОББИ
Уве ГРЕТЕР
Маттиас НЕТТЕКОФЕН
Штефан Рёфер
Марк РОДЖЕРС-ЭВАНС
Роджер Славик
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Айдгенёссише Технише Хохшуле Цюрих
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг, Айдгенёссише Технише Хохшуле Цюрих filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201691982A1 publication Critical patent/EA201691982A1/ru
Publication of EA030032B1 publication Critical patent/EA030032B1/ru

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
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  • Biochemistry (AREA)
  • Biophysics (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Настоящее изобретение относится к соединению формулы (I)где R-Rявляются такими, как определено в описании или формуле изобретения. Соединение формулы (I) может применяться в качестве лекарственного средства.
EA201691982A 2014-04-04 2015-04-01 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов EA030032B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14163554 2014-04-04
PCT/EP2015/057144 WO2015150438A1 (en) 2014-04-04 2015-04-01 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists

Publications (2)

Publication Number Publication Date
EA201691982A1 true EA201691982A1 (ru) 2017-01-30
EA030032B1 EA030032B1 (ru) 2018-06-29

Family

ID=50424142

Family Applications (1)

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EA201691982A EA030032B1 (ru) 2014-04-04 2015-04-01 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов

Country Status (18)

Country Link
US (2) US20160376237A1 (ru)
EP (1) EP3126349B1 (ru)
JP (1) JP6353072B2 (ru)
KR (2) KR20160132495A (ru)
CN (2) CN106458984A (ru)
AR (1) AR099932A1 (ru)
AU (1) AU2015239537B2 (ru)
CA (1) CA2944256A1 (ru)
CL (1) CL2016002389A1 (ru)
CR (1) CR20160459A (ru)
EA (1) EA030032B1 (ru)
IL (1) IL247773A0 (ru)
MX (1) MX2016012690A (ru)
PE (1) PE20161407A1 (ru)
PH (1) PH12016501849A1 (ru)
SG (1) SG11201608246VA (ru)
TW (1) TW201625538A (ru)
WO (1) WO2015150438A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2899168A1 (en) 2013-03-26 2014-10-02 F. Hoffmann-La Roche Ag Novel pyridine derivatives
LT3126354T (lt) 2014-04-04 2020-03-25 H. Lundbeck A/S Halogeninti kvinazolin-thf-aminai kaip pde1 inhibitoriai
AU2016368475B2 (en) 2015-12-09 2021-03-04 F. Hoffmann-La Roche Ag Phenyl derivatives as cannabinoid receptor 2 agonists
GB201703282D0 (en) * 2017-03-01 2017-04-12 Glaxosmithkline Intellectual Property (No 2) Ltd Compounds
EP3642200B1 (en) 2017-06-20 2023-05-03 F. Hoffmann-La Roche AG Pyridine derivatives
KR20210028202A (ko) * 2018-06-27 2021-03-11 에프. 호프만-라 로슈 아게 칸나비노이드 수용체 2의 억제제로서 신규한 피리딘 및 피라진 화합물
JP7454512B2 (ja) 2018-06-27 2024-03-22 エフ． ホフマン－ラ ロシュ アーゲー 優先的カンナビノイド２アゴニストとしてのピリジン及びピラジン誘導体
WO2020002280A1 (en) * 2018-06-27 2020-01-02 F. Hoffmann-La Roche Ag Novel azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
WO2023145372A1 (ja) * 2022-01-28 2023-08-03 日本曹達株式会社 アミド化合物の製造方法
CN115160306B (zh) * 2022-08-04 2024-03-26 上海皓鸿生物医药科技有限公司 一种特力利汀中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2664621A1 (en) * 2006-10-04 2008-04-10 F. Hoffmann-La Roche Ag Pyrazine-2-carboxamide derivatives
WO2012031817A1 (en) * 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Determination of abca1 protein levels in cells
US9321727B2 (en) * 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
US9403808B2 (en) * 2011-10-28 2016-08-02 Hoffmann-La Roche Inc. Pyrazine derivatives
EP3357918A1 (en) * 2012-12-07 2018-08-08 F. Hoffmann-La Roche AG Novel pyridine derivatives
US9303012B2 (en) * 2012-12-07 2016-04-05 Hoffman-La Roche Inc. Pyridine-2-amides useful as CB2 agonists

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Publication number Publication date
KR20180072827A (ko) 2018-06-29
EA030032B1 (ru) 2018-06-29
MX2016012690A (es) 2017-04-27
CL2016002389A1 (es) 2017-03-17
AU2015239537A1 (en) 2016-11-17
SG11201608246VA (en) 2016-10-28
IL247773A0 (en) 2016-11-30
EP3126349A1 (en) 2017-02-08
US20180327360A1 (en) 2018-11-15
CN106458984A (zh) 2017-02-22
AR099932A1 (es) 2016-08-31
EP3126349B1 (en) 2019-06-26
TW201625538A (zh) 2016-07-16
CR20160459A (es) 2016-12-02
KR20160132495A (ko) 2016-11-18
JP2017509688A (ja) 2017-04-06
WO2015150438A1 (en) 2015-10-08
CA2944256A1 (en) 2015-10-08
AU2015239537B2 (en) 2019-04-04
US20160376237A1 (en) 2016-12-29
JP6353072B2 (ja) 2018-07-04
PH12016501849A1 (en) 2016-12-19
CN111170938A (zh) 2020-05-19
PE20161407A1 (es) 2016-12-28

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