EA201591805A1 - Оксабицикло [2.2.2] кислоты - модуляторы gpr120 - Google Patents

Оксабицикло [2.2.2] кислоты - модуляторы gpr120

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Publication number
EA201591805A1
EA201591805A1 EA201591805A EA201591805A EA201591805A1 EA 201591805 A1 EA201591805 A1 EA 201591805A1 EA 201591805 A EA201591805 A EA 201591805A EA 201591805 A EA201591805 A EA 201591805A EA 201591805 A1 EA201591805 A1 EA 201591805A1
Authority
EA
Eurasian Patent Office
Prior art keywords
modulators
gpr120
oxabiciclo
acids
compounds
Prior art date
Application number
EA201591805A
Other languages
English (en)
Inventor
Хао Чзан
Питер Т.В. Чэн
Шон Чэнь
Шинвэй Тао
Шун С. У
Лидет А. Негаш
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201591805A1 publication Critical patent/EA201591805A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

В изобретении предусмотрены соединения формулы (I)или их стереоизомер или фармацевтически приемлемая соль, где все переменные являются такими, которые определены в описании изобретения. Указанные соединения представляют собой модуляторы сопряженного с G-белком рецептора GPR120, которые можно применять в качестве лекарственных средств.
EA201591805A 2013-03-14 2014-03-13 Оксабицикло [2.2.2] кислоты - модуляторы gpr120 EA201591805A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361782339P 2013-03-14 2013-03-14
US14/205,421 US8962660B2 (en) 2013-03-14 2014-03-12 Oxabicyclo [2.2.2] acid GPR120 modulators
PCT/US2014/025287 WO2014151247A1 (en) 2013-03-14 2014-03-13 Oxabicyclo [2.2.2] acid gpr120 modulators

Publications (1)

Publication Number Publication Date
EA201591805A1 true EA201591805A1 (ru) 2016-01-29

Family

ID=51529985

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591805A EA201591805A1 (ru) 2013-03-14 2014-03-13 Оксабицикло [2.2.2] кислоты - модуляторы gpr120

Country Status (13)

Country Link
US (1) US8962660B2 (ru)
EP (1) EP2970327B1 (ru)
JP (1) JP2016512556A (ru)
KR (1) KR20150128860A (ru)
CN (1) CN105189516B (ru)
AU (1) AU2014235172B2 (ru)
BR (1) BR112015021596A2 (ru)
CA (1) CA2905448A1 (ru)
EA (1) EA201591805A1 (ru)
IL (1) IL241323B (ru)
MX (1) MX362383B (ru)
SG (1) SG11201506799RA (ru)
WO (1) WO2014151247A1 (ru)

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US9598390B2 (en) 2013-03-14 2017-03-21 Bristol-Myers Squibb Company Bicyclo[2.2.2]acid GPR120 modulators
BR112015021990A2 (pt) 2013-03-14 2017-07-18 Bristol Myers Squibb Co moduladores de gpr120 de ácido biciclo [2.2.1]
EP2860177A3 (en) * 2013-09-20 2015-06-10 Bayer Intellectual Property GmbH Synthesis of functionalized arenes
US10023519B2 (en) 2014-09-09 2018-07-17 Bristol-Myers Squibb Company Cyclobutane containing carboxylic acid GPR120 modulators
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ES2705773T3 (es) 2014-09-09 2019-03-26 Bristol Myers Squibb Co Moduladores de GPR120 de ácido ciclopropanocarboxílico
KR20170031400A (ko) 2015-09-11 2017-03-21 주식회사 만도 전자식 브레이크 시스템
US11008317B2 (en) 2016-03-18 2021-05-18 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase and/or EPX
CA3041033A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Monocyclic compounds useful as gpr120 modulators
CN108456213B (zh) * 2017-02-22 2021-01-15 浙江九洲药业股份有限公司 一种3-氟-4-羟基环己烷羧酸酯的制备方法
CN111868035A (zh) 2018-03-15 2020-10-30 阿克萨姆股份公司 取代的吡唑ffa4/gpr120受体激动剂
ES2941774T3 (es) 2018-09-18 2023-05-25 Bristol Myers Squibb Co Acidos oxabiciclo como antagonistas de LPA
CN111233889B (zh) * 2020-03-02 2021-09-14 北方民族大学 一种噻吩并[3,4-b]-1,4-二噁英-2-甲醇衍生物的制备方法
CN113912619B (zh) * 2021-11-26 2022-12-06 沈阳药科大学 五味子中提取分离的倍半萜化合物及其方法和应用

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Also Published As

Publication number Publication date
MX362383B (es) 2019-01-15
IL241323A0 (en) 2015-11-30
CA2905448A1 (en) 2014-09-25
MX2015011913A (es) 2015-12-09
CN105189516B (zh) 2017-08-15
AU2014235172B2 (en) 2018-04-26
KR20150128860A (ko) 2015-11-18
WO2014151247A1 (en) 2014-09-25
EP2970327A1 (en) 2016-01-20
SG11201506799RA (en) 2015-09-29
US20140275173A1 (en) 2014-09-18
JP2016512556A (ja) 2016-04-28
AU2014235172A1 (en) 2015-11-05
CN105189516A (zh) 2015-12-23
US8962660B2 (en) 2015-02-24
IL241323B (en) 2018-10-31
BR112015021596A2 (pt) 2017-07-18
EP2970327B1 (en) 2017-05-03

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