EA201590854A1 - Пиридин-2-амиды, пригодные в качестве агонистов каннабиноидного рецептора 2 - Google Patents
Пиридин-2-амиды, пригодные в качестве агонистов каннабиноидного рецептора 2Info
- Publication number
- EA201590854A1 EA201590854A1 EA201590854A EA201590854A EA201590854A1 EA 201590854 A1 EA201590854 A1 EA 201590854A1 EA 201590854 A EA201590854 A EA 201590854A EA 201590854 A EA201590854 A EA 201590854A EA 201590854 A1 EA201590854 A1 EA 201590854A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- agonists
- amides
- pyridine
- cannabinoid receptor
- formula
- Prior art date
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Изобретение относится к агонистам СВ2 формулы (I), где R-Rопределены, как в описании и в формуле изобретения. Соединение формулы (I) можно использовать в качестве лекарства.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12196032 | 2012-12-07 | ||
PCT/EP2013/075443 WO2014086806A1 (en) | 2012-12-07 | 2013-12-04 | Pyridine-2-amides useful as cb2 agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201590854A1 true EA201590854A1 (ru) | 2015-09-30 |
EA025841B1 EA025841B1 (ru) | 2017-02-28 |
Family
ID=47290808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590854A EA025841B1 (ru) | 2012-12-07 | 2013-12-04 | Пиридин-2-амиды, пригодные в качестве агонистов каннабиноидного рецептора 2 |
Country Status (32)
Country | Link |
---|---|
US (1) | US9303012B2 (ru) |
EP (1) | EP2928868B1 (ru) |
JP (1) | JP6426619B2 (ru) |
KR (1) | KR20150091080A (ru) |
CN (1) | CN104854092B (ru) |
AR (1) | AR093806A1 (ru) |
AU (1) | AU2013354114B2 (ru) |
BR (1) | BR112015009600A2 (ru) |
CA (1) | CA2885987A1 (ru) |
CL (1) | CL2015001538A1 (ru) |
CR (1) | CR20150204A (ru) |
DK (1) | DK2928868T3 (ru) |
EA (1) | EA025841B1 (ru) |
ES (1) | ES2643058T3 (ru) |
HK (1) | HK1208033A1 (ru) |
HR (1) | HRP20171445T1 (ru) |
IL (1) | IL237988A (ru) |
LT (1) | LT2928868T (ru) |
MA (2) | MA40308A1 (ru) |
MX (1) | MX2015007033A (ru) |
MY (1) | MY182328A (ru) |
PE (1) | PE20151089A1 (ru) |
PH (1) | PH12015501073B1 (ru) |
PL (1) | PL2928868T3 (ru) |
PT (1) | PT2928868T (ru) |
RS (1) | RS56423B1 (ru) |
SG (1) | SG11201504122YA (ru) |
SI (1) | SI2928868T1 (ru) |
TW (1) | TWI617551B (ru) |
UA (1) | UA114655C2 (ru) |
WO (1) | WO2014086806A1 (ru) |
ZA (1) | ZA201502872B (ru) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102369407B1 (ko) | 2013-03-07 | 2022-03-02 | 에프. 호프만-라 로슈 아게 | 신규 피라졸 유도체 |
RS56927B1 (sr) | 2013-03-26 | 2018-05-31 | Hoffmann La Roche | Novi derivati piridina |
AU2014261585B2 (en) | 2013-05-02 | 2018-03-08 | F. Hoffmann-La Roche Ag | Purine derivatives as CB2 receptor agonists |
AU2014261546B2 (en) | 2013-05-02 | 2018-01-18 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-d]pyrimidine derivatives as CB2 receptor agonists |
WO2015032769A1 (en) | 2013-09-06 | 2015-03-12 | F. Hoffmann-La Roche Ag | Novel triazolo[4,5-d]pyrimidine derivatives |
MA39843A (fr) * | 2014-04-04 | 2017-02-08 | Hoffmann La Roche | Pyridine-2-amides utiles comme agonistes de cb2 |
EA030032B1 (ru) * | 2014-04-04 | 2018-06-29 | Ф. Хоффманн-Ля Рош Аг | 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов |
WO2016121959A1 (ja) * | 2015-01-30 | 2016-08-04 | 富士フイルム株式会社 | イソインドリン化合物またはその塩の製造方法および新規イソインドリン化合物またはその塩 |
EP3386951B1 (en) * | 2015-12-09 | 2020-02-26 | H. Hoffnabb-La Roche Ag | Phenyl derivatives as cannabinoid receptor 2 agonists |
CN106187910A (zh) * | 2016-07-07 | 2016-12-07 | 浙江大学 | 哒嗪类衍生物及其制备方法和用途 |
EP3642200B1 (en) | 2017-06-20 | 2023-05-03 | F. Hoffmann-La Roche AG | Pyridine derivatives |
CN112074513B (zh) | 2018-06-27 | 2024-06-14 | 豪夫迈·罗氏有限公司 | 作为优先大麻素2激动剂的吡啶和吡嗪衍生物 |
AU2019294256B2 (en) | 2018-06-27 | 2024-06-20 | Eth Zuerich | Novel pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 |
WO2020002314A1 (en) | 2018-06-27 | 2020-01-02 | F. Hoffmann-La Roche Ag | Radiolabeled cannabinoid receptor 2 ligand |
WO2022128050A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammation and pain |
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MX2009003316A (es) * | 2006-10-04 | 2009-04-09 | Hoffmann La Roche | Derivados de pirazina-2-carboxamida como moduladores receptores de cb2. |
WO2012031817A1 (en) | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
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