AR093806A1 - Derivados de piridina agonistas de receptores cb2 - Google Patents

Derivados de piridina agonistas de receptores cb2

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Publication number
AR093806A1
AR093806A1 ARP130104506A ARP130104506A AR093806A1 AR 093806 A1 AR093806 A1 AR 093806A1 AR P130104506 A ARP130104506 A AR P130104506A AR P130104506 A ARP130104506 A AR P130104506A AR 093806 A1 AR093806 A1 AR 093806A1
Authority
AR
Argentina
Prior art keywords
phenylalkyl
heptyl
alkyl
azabicyclo
oxa
Prior art date
Application number
ARP130104506A
Other languages
English (en)
Inventor
Nettekoven Matthias
Schulz-Gasch Tanja
Rogers-Evans Mark
Schaffter Ernst
Grether Uwe
Roever Stephan
Bendels Stefanie
Kimbara Atsushi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR093806A1 publication Critical patent/AR093806A1/es

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Reivindicación 1: Un compuesto de la fórmula (1), en la que: R¹ es cicloalquilalcoxi, halofenilo, tetrahidrofuranilalcoxi, halofenilalquilo, haloalquiloxi, alquilsulfonilo, tetrahidropiranilalcoxi o halógeno; R² es alquilo, pirrolidinilo, cicloalquilo, haloazetidinilo, haloalquilo, cicloalquilalcoxi, haloalquiloxi, halocicloalquilo, hidroxicicloalquilo o halooxetanilo; uno de R³ y R⁴ es alquilo, cicloalquilo, haloalquilo o hidroxialquilo y el otro es alquilo, alquiloxialquilo, (haloazetidinil)(cicloalquiloxi)piridinilcarboniloxialquilo haloalquilcicloalquilo, hidroxialquilo, fenilalquilo, alcoxicarbonilalquilo, carboxialquilo, alquilaminocarbonilalquilo, (alquiloxadiazolil)(cicloalquilalquil)alquilo, (alquiloxadiazolil)(cicloalquil)alquilo, piridazinilalquilo, aminocarbonilalquilo, alquiloxadiazolilalquilo, alquiltetrazolilalquilo, formilo, fenilo, dialquilpirazolilo, alquilcarbonilpiperidinilo o cicloalquilalquilo; o R³ y R⁴ junto con el átomo de nitrógeno, al que están unidos, forman un heterociclilo o heterociclilo sustituido; dicho heterociclilo es el 6-oxa-1-aza-espiro[3.3]heptilo, oxazolidinilo, morfolinilo, pirrolidinilo, piperazinilo, 2-oxa-5-aza-espiro[3.4]octilo piperidinilo, 6-azabiciclo-[3.2.1]octilo, imidazolidinilo, 4-azaespiro[2.4]heptilo, 2-azabiciclo[2.2.1]heptilo, 2-tia-5-azabiciclo[2.2.1]heptilo, 2,5-diazabiciclo[2.2.1]heptilo, 2-oxa-5-azabiciclo[2.2.1]-heptilo, hexahidrofuro[2,3-c]pirrolilo, 2-tia-6-azaespiro-[3.3]heptilo, 1,8-diaza-espiro[4.5]decilo, 1-oxa-7-azaespiro-[4.4]nonilo, 5-oxa-2-aza-espiro[3.4]octilo, 8-oxa-3-azabiciclo[3.2.1]octilo, 3-oxa-8-azabiciclo[3.2.1]octilo, tiomorfolinilo, tiazolidinilo, 5-azaespiro[3.4]octilo, azetidinilo, 5-aza-espiro[2.4]heptilo, 3-azabiciclo[3.1.0]-hexilo o 5-aza-espiro[2.4]heptilo, 1,3,3a,4,6,6a-hexahidrofuro[3,4-c]-pirrolilo; y dicho heterociclilo sustituido es un heterociclilo sustituido de una a cuatro veces por sustituyentes elegidos con independencia entre alquilo, oxo, hidroxilo, carboxilo, alquilcarbonilamino, alquiloxialquilo, hidroxialquilo, aminocarbonilo, halógeno, fenilalquilo, fenilo, alcoxicarbonilo, cicloalquilalquilo, fenilalcoxicarbonilo, cicloalquilo, halohidroxialquilo y haloalquilo; con la condición de que R³ y R⁴ junto con el átomo de nitrógeno, al que están unidos, no formen un piperidinilo sin sustituir, un tiomorfolinilo sin sustituir ni un hidroxialquilpirrolidinilo; o una sal o un éster farmacéuticamente aceptable del mismo.
ARP130104506A 2012-12-07 2013-12-05 Derivados de piridina agonistas de receptores cb2 AR093806A1 (es)

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US (1) US9303012B2 (es)
EP (1) EP2928868B1 (es)
JP (1) JP6426619B2 (es)
KR (1) KR20150091080A (es)
CN (1) CN104854092B (es)
AR (1) AR093806A1 (es)
AU (1) AU2013354114B2 (es)
BR (1) BR112015009600A2 (es)
CA (1) CA2885987A1 (es)
CL (1) CL2015001538A1 (es)
CR (1) CR20150204A (es)
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PE20151977A1 (es) 2013-05-02 2016-01-07 Hoffmann La Roche Nuevos derivados de purina
HUE035333T2 (en) 2013-05-02 2018-05-02 Hoffmann La Roche Pyrrolo [2,3-d] pyrimidine derivatives as CB2 receptor agonists
RS58390B1 (sr) 2013-09-06 2019-04-30 Hoffmann La Roche Derivati triazolo[4,5-d]pirimidina kao antagonisti cb2 receptora
EA030032B1 (ru) * 2014-04-04 2018-06-29 Ф. Хоффманн-Ля Рош Аг 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов
AR099933A1 (es) * 2014-04-04 2016-08-31 Hoffmann La Roche Derivados heterocíclicos de piridina agonistas de cb2
WO2016121959A1 (ja) * 2015-01-30 2016-08-04 富士フイルム株式会社 イソインドリン化合物またはその塩の製造方法および新規イソインドリン化合物またはその塩
SI3386951T1 (sl) 2015-12-09 2020-07-31 F. Hoffmann-La Roche Ag Fenilni derivati kot agonisti kanabinoidnega receptorja 2
CN106187910A (zh) * 2016-07-07 2016-12-07 浙江大学 哒嗪类衍生物及其制备方法和用途
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