AR105845A1 - Compuestos de heteroarilo bicíclicos fusionados como moduladores de la función irak4 - Google Patents
Compuestos de heteroarilo bicíclicos fusionados como moduladores de la función irak4Info
- Publication number
- AR105845A1 AR105845A1 ARP160102625A ARP160102625A AR105845A1 AR 105845 A1 AR105845 A1 AR 105845A1 AR P160102625 A ARP160102625 A AR P160102625A AR P160102625 A ARP160102625 A AR P160102625A AR 105845 A1 AR105845 A1 AR 105845A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- optionally substituted
- 6alkyl
- deuterium
- alkyl
- Prior art date
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C07D491/18—Bridged systems
Abstract
También composiciones farmacéuticas y uso en tratamiento de enfermedades inflamatorias. Reivindicación 1: Un compuesto caracterizado por la fórmula (1), en donde X, X, Y e Y son, cada uno independientemente, CH o N; Z es C o N; siempre que no más de tres de X, X, Z, Y e Y sean N; R¹ es C₁₋₆alquilo o -(C₁₋₆alquil)ₙ(C₁₋₆cicloalquilo), en donde el alquilo o cicloalquilo se sustituyen opcionalmente con deuterio, halógeno, CN, OH o C₁₋₆alcoxi; R² es hidrógeno o metilo; R³ es hidrógeno, deuterio, halógeno, nitrilo, -(CH₂)ₜNR⁸ᵃR⁸ᵇ, -(CH₂)ₜ(arilo de 6 a 10 miembros) o un -(CH₂)ₜ(heteroarilo de 5 a 10 miembros), que tiene 1 a 3 heteroátomos seleccionados de N, O ó S, en donde el arilo o heteroarilo se sustituyen opcionalmente con 1 a 3 C₁₋₆alquilo, deuterio, halógeno, CN, OH, hidroxi-C₁₋₆alquilo o C₁₋₆alcoxi; en donde el alquilo se sustituye opcionalmente con hidroxilo, halógeno, CN o C₁₋₃alcoxi; R⁴ᵃ y R⁴ᵇ son, cada uno independientemente, hidrógeno, flúor, OH, C₁₋₃alcoxi o CH₂OR⁷, en donde R⁷, junto con R¹, es un C₁₋₄alquileno, opcionalmente sustituido con halógeno o alquilo; R⁵ᵃ y R⁵ᵇ son, cada uno independientemente, hidrógeno, C₁₋₃alquilo o C₁₋₃alcoxi, en donde el alquilo o alcoxi se sustituyen opcionalmente con 1 a 3 deuterio, halógeno, OH o CN; o R⁵ᵃ y R⁵ᵇ, junto con el átomo al que están unidos, forman un C₃₋₇cicloalquilo o C₃₋₇heterocicloalquilo, en donde el cicloalquilo o heterocicloalquilo se sustituyen opcionalmente con 1 a 3 deuterio, halógeno, OH, CN o C₁₋₃alquilo; R⁶ es hidrógeno o C₁₋₃alquilo; o R⁵ᵇ y R⁶, junto con el átomo al que están unidos, forman un C₃₋₇cicloalquilo o C₃₋₇heterocicloalquilo, en donde el cicloalquilo o heterocicloalquilo se sustituyen opcionalmente con 1 a 3 deuterio, halógeno, OH, CN o C₁₋₃alquilo; R⁸ᵃ y R⁸ᵇ son, cada uno independientemente, hidrógeno, -S(O)₂R⁹ o -C(O)R⁹; R⁹ es C₁₋₆alquilo, C₁₋₆cicloalquilo, arilo de 6 a 10 miembros o un heteroarilo de 5 a 10 miembros, que tiene de 1 a 3 heteroátomos, en donde el alquilo, cicloalquilo, arilo o heteroarilo se sustituyen opcionalmente con 1 a 3 C₁₋₆alquilo, halógeno, CN, OH, C₁₋₆alcoxi o C₁₋₆hidroxi; n es 0 ó 1; t es 0, 1, 2 ó 3; o una sal aceptable desde el punto de vista farmacéutico del compuesto o un tautómero del compuesto o de la sal.
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US201562210573P | 2015-08-27 | 2015-08-27 |
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AR105845A1 true AR105845A1 (es) | 2017-11-15 |
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ARP160102625A AR105845A1 (es) | 2015-08-27 | 2016-08-26 | Compuestos de heteroarilo bicíclicos fusionados como moduladores de la función irak4 |
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EP (2) | EP3858825A1 (es) |
JP (1) | JP6804524B2 (es) |
KR (1) | KR102029124B1 (es) |
CN (1) | CN107949559B (es) |
AR (1) | AR105845A1 (es) |
AU (1) | AU2016311376B2 (es) |
BR (1) | BR112018001650A2 (es) |
CA (1) | CA2996389C (es) |
CY (1) | CY1123994T1 (es) |
DK (1) | DK3341367T3 (es) |
ES (1) | ES2865199T3 (es) |
HK (1) | HK1254323A1 (es) |
HR (1) | HRP20210472T1 (es) |
HU (1) | HUE053705T2 (es) |
IL (2) | IL257731B (es) |
LT (1) | LT3341367T (es) |
MX (1) | MX2018002402A (es) |
PL (1) | PL3341367T3 (es) |
PT (1) | PT3341367T (es) |
RS (1) | RS61719B1 (es) |
RU (1) | RU2684324C1 (es) |
SI (1) | SI3341367T1 (es) |
TW (1) | TWI647214B (es) |
WO (1) | WO2017033093A1 (es) |
ZA (1) | ZA201800388B (es) |
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