BR112015009600A2 - piridina-2-amidas úteis como agonistas cb2 - Google Patents

piridina-2-amidas úteis como agonistas cb2

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Publication number
BR112015009600A2
BR112015009600A2 BR112015009600A BR112015009600A BR112015009600A2 BR 112015009600 A2 BR112015009600 A2 BR 112015009600A2 BR 112015009600 A BR112015009600 A BR 112015009600A BR 112015009600 A BR112015009600 A BR 112015009600A BR 112015009600 A2 BR112015009600 A2 BR 112015009600A2
Authority
BR
Brazil
Prior art keywords
agonists
pyridine
amides useful
amides
useful
Prior art date
Application number
BR112015009600A
Other languages
English (en)
Inventor
Kimbara Atsushi
Schaffter Ernst
Rogers Evans Mark
Nettekoven Matthias
Bendels Stefanie
Roever Stephan
Schulz Gasch Tanja
Grether Uwe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015009600A2 publication Critical patent/BR112015009600A2/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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Abstract

1/1 resumo piridina-2-amidas úteis como agonistas cb2 a invenção refere-se a agonistas cb2 de fórmula (i) em que r1 a r4 são definidos como na descrição e nas reivindicações. o composto de fórmula (i) pode ser usado como um medicamento.
BR112015009600A 2012-12-07 2013-12-04 piridina-2-amidas úteis como agonistas cb2 BR112015009600A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12196032 2012-12-07
PCT/EP2013/075443 WO2014086806A1 (en) 2012-12-07 2013-12-04 Pyridine-2-amides useful as cb2 agonists

Publications (1)

Publication Number Publication Date
BR112015009600A2 true BR112015009600A2 (pt) 2017-07-04

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BR112015009600A BR112015009600A2 (pt) 2012-12-07 2013-12-04 piridina-2-amidas úteis como agonistas cb2

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US (1) US9303012B2 (pt)
EP (1) EP2928868B1 (pt)
JP (1) JP6426619B2 (pt)
KR (1) KR20150091080A (pt)
CN (1) CN104854092B (pt)
AR (1) AR093806A1 (pt)
AU (1) AU2013354114B2 (pt)
BR (1) BR112015009600A2 (pt)
CA (1) CA2885987A1 (pt)
CL (1) CL2015001538A1 (pt)
CR (1) CR20150204A (pt)
DK (1) DK2928868T3 (pt)
EA (1) EA025841B1 (pt)
ES (1) ES2643058T3 (pt)
HK (1) HK1208033A1 (pt)
HR (1) HRP20171445T1 (pt)
IL (1) IL237988A (pt)
LT (1) LT2928868T (pt)
MA (2) MA40308A1 (pt)
MX (1) MX2015007033A (pt)
MY (1) MY182328A (pt)
PE (1) PE20151089A1 (pt)
PH (1) PH12015501073A1 (pt)
PL (1) PL2928868T3 (pt)
PT (1) PT2928868T (pt)
RS (1) RS56423B1 (pt)
SG (1) SG11201504122YA (pt)
SI (1) SI2928868T1 (pt)
TW (1) TWI617551B (pt)
UA (1) UA114655C2 (pt)
WO (1) WO2014086806A1 (pt)
ZA (1) ZA201502872B (pt)

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PE20151539A1 (es) 2013-03-07 2015-10-28 Hoffmann La Roche Nuevos derivados de pirazol
PE20151559A1 (es) 2013-03-26 2015-11-05 Hoffmann La Roche Nuevos derivados de piridina
EP2991988B1 (en) 2013-05-02 2017-05-31 F. Hoffmann-La Roche AG Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists
KR102330794B1 (ko) 2013-05-02 2021-11-26 에프. 호프만-라 로슈 아게 Cb2 수용체 작용제로서의 퓨린 유도체
EP3483163B1 (en) 2013-09-06 2021-06-23 F. Hoffmann-La Roche AG Triazolo[4,5-d]pyrimidine derivatives as cb2 receptor antagonists
CN106132958A (zh) * 2014-04-04 2016-11-16 豪夫迈·罗氏有限公司 作为cb2激动剂的吡啶‑2‑酰胺类化合物
EA030032B1 (ru) * 2014-04-04 2018-06-29 Ф. Хоффманн-Ля Рош Аг 5,6-дизамещенные пиридин-2-карбоксамиды в качестве агонистов каннабиноидных рецепторов
JP6243065B2 (ja) * 2015-01-30 2017-12-06 富士フイルム株式会社 イソインドリン化合物またはその塩の製造方法および新規イソインドリン化合物またはその塩
BR112018011562B1 (pt) * 2015-12-09 2023-05-02 F. Hoffmann-La Roche Ag Novos derivados de fenil
CN106187910A (zh) * 2016-07-07 2016-12-07 浙江大学 哒嗪类衍生物及其制备方法和用途
JP7300398B2 (ja) 2017-06-20 2023-06-29 エフ． ホフマン－ラ ロシュ アーゲー ピリジン誘導体
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