MA38218A1 - Pyridine-2-amides utiles comme agonistes de cb2 - Google Patents

Pyridine-2-amides utiles comme agonistes de cb2

Info

Publication number
MA38218A1
MA38218A1 MA38218A MA38218A MA38218A1 MA 38218 A1 MA38218 A1 MA 38218A1 MA 38218 A MA38218 A MA 38218A MA 38218 A MA38218 A MA 38218A MA 38218 A1 MA38218 A1 MA 38218A1
Authority
MA
Morocco
Prior art keywords
agonists
pyridine
amides useful
amides
useful
Prior art date
Application number
MA38218A
Other languages
English (en)
Inventor
Uwe Grether
Atsushi Kimbara
Matthias Nettekoven
Stephan Roever
Mark Rogers-Evans
Tanja Schulz-Gasch
Stefanie Bendels
Ernst Schaffter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA38218A1 publication Critical patent/MA38218A1/fr

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract

La présente invention concerne des agonistes de cb2 de formule (i) où r1 à r4 sont tels que définis dans la description et les revendications. Le composé de formule (i) peut être utilisé comme médicament.
MA38218A 2012-12-07 2013-12-04 Pyridine-2-amides utiles comme agonistes de cb2 MA38218A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12196032 2012-12-07
PCT/EP2013/075443 WO2014086806A1 (fr) 2012-12-07 2013-12-04 Pyridine-2-amides utiles comme agonistes de cb2

Publications (1)

Publication Number Publication Date
MA38218A1 true MA38218A1 (fr) 2016-04-29

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
MA38218A MA38218A1 (fr) 2012-12-07 2013-12-04 Pyridine-2-amides utiles comme agonistes de cb2
MA40308A MA40308A1 (fr) 2012-12-07 2013-12-04 Pyridine-2- amides utiles comme agonistes de cb2

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA40308A MA40308A1 (fr) 2012-12-07 2013-12-04 Pyridine-2- amides utiles comme agonistes de cb2

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US (1) US9303012B2 (fr)
EP (1) EP2928868B1 (fr)
JP (1) JP6426619B2 (fr)
KR (1) KR20150091080A (fr)
CN (1) CN104854092B (fr)
AR (1) AR093806A1 (fr)
AU (1) AU2013354114B2 (fr)
BR (1) BR112015009600A2 (fr)
CA (1) CA2885987A1 (fr)
CL (1) CL2015001538A1 (fr)
CR (1) CR20150204A (fr)
DK (1) DK2928868T3 (fr)
EA (1) EA025841B1 (fr)
ES (1) ES2643058T3 (fr)
HK (1) HK1208033A1 (fr)
HR (1) HRP20171445T1 (fr)
IL (1) IL237988A (fr)
LT (1) LT2928868T (fr)
MA (2) MA38218A1 (fr)
MX (1) MX2015007033A (fr)
MY (1) MY182328A (fr)
PE (1) PE20151089A1 (fr)
PH (1) PH12015501073B1 (fr)
PL (1) PL2928868T3 (fr)
PT (1) PT2928868T (fr)
RS (1) RS56423B1 (fr)
SG (1) SG11201504122YA (fr)
SI (1) SI2928868T1 (fr)
TW (1) TWI617551B (fr)
UA (1) UA114655C2 (fr)
WO (1) WO2014086806A1 (fr)
ZA (1) ZA201502872B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2629751T3 (es) 2013-03-07 2017-08-14 F. Hoffmann-La Roche Ag Derivados de pirazol novedosos
EA027569B1 (ru) 2013-03-26 2017-08-31 Ф.Хоффманн-Ля Рош Аг Производные пиридина
UA116801C2 (uk) 2013-05-02 2018-05-10 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ ЯК АГОНІСТИ РЕЦЕПТОРА CB2
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PE20161407A1 (es) * 2014-04-04 2016-12-28 Hoffmann La Roche Piridina 5,6 disustituida -2-carboxamidas como agonistas del receptor canabinoide
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