AR114793A1 - Moduladores de enzimas modificadoras de metilo, composiciones y usos de los mismos - Google Patents

Moduladores de enzimas modificadoras de metilo, composiciones y usos de los mismos

Info

Publication number
AR114793A1
AR114793A1 ARP190101038A ARP190101038A AR114793A1 AR 114793 A1 AR114793 A1 AR 114793A1 AR P190101038 A ARP190101038 A AR P190101038A AR P190101038 A ARP190101038 A AR P190101038A AR 114793 A1 AR114793 A1 AR 114793A1
Authority
AR
Argentina
Prior art keywords
alkyl
halo
alkoxy
modulators
compositions
Prior art date
Application number
ARP190101038A
Other languages
English (en)
Inventor
Jacob I Stuckey
Ludivine Moine
Avinash Khanna
Victor S Gehling
Alexandre Ct
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of AR114793A1 publication Critical patent/AR114793A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reivindicación 1: Un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo, caracterizado porque: R¹ es halo, -SC₁₋₄ alquilo, -SC₃₋₇ cicloalquilo, o -S[halo-C₁₋₄ alquilo]; X es CH o N; R² es hidrógeno, halo, C₁₋₄ alquilo, o halo-C₁₋₄ alquilo; R³ es halo, C₁₋₄ alquilo, o halo-C₁₋₄ alquilo; R⁴ es C₃₋₇ cicloalquilo o heterociclilo de 4 - 7 miembros, cada uno de los cuales es opcionalmente sustituido con 1 a 3 grupos seleccionados de halo, C₁₋₄ alquilo, halo-C₁₋₄ alquilo, C₁₋₄ alcoxi, halo-C₁₋₄ alcoxi y -NRᵃRᵇ; Rᵃ es hidrógeno, C₁₋₄ alquilo, o halo-C₁₋₄ alquilo; Rᵇ es C₁₋₄ alquilo, halo-C₁₋₄ alquilo, o heterociclilo de 4 - 7 miembros, en donde el heterociclilo es opcionalmente sustituido con 1 a 3 grupos seleccionados de halo, C₁₋₄ alquilo, halo-C₁₋₄ alquilo, C₁₋₄ alcoxi y halo-C₁₋₄ alcoxi; o Rᵃ y Rᵇ junto con el átomo de nitrógeno al cual se unen forman un heterociclilo de 4 - 7 miembros opcionalmente sustituido con 1 a 3 grupos seleccionados de halo, C₁₋₄ alquilo, halo-C₁₋₄ alquilo y -ORᶜ; Rᶜ es C₁₋₄ alquilo, halo-C₁₋₄ alquilo, o C₃₋₇ cicloalquilo; y R⁵ es halo, C₁₋₄ alquilo, o halo-C₁₋₄ alquilo.
ARP190101038A 2018-04-18 2019-04-17 Moduladores de enzimas modificadoras de metilo, composiciones y usos de los mismos AR114793A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862659408P 2018-04-18 2018-04-18

Publications (1)

Publication Number Publication Date
AR114793A1 true AR114793A1 (es) 2020-10-14

Family

ID=66429588

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101038A AR114793A1 (es) 2018-04-18 2019-04-17 Moduladores de enzimas modificadoras de metilo, composiciones y usos de los mismos

Country Status (31)

Country Link
US (3) US10689371B2 (es)
EP (2) EP3781561B1 (es)
JP (2) JP7256823B2 (es)
KR (1) KR20210003160A (es)
CN (1) CN111989325A (es)
AR (1) AR114793A1 (es)
AU (1) AU2019255310B2 (es)
BR (1) BR112020021194A2 (es)
CA (1) CA3098428A1 (es)
CL (1) CL2020002698A1 (es)
CO (1) CO2020014217A2 (es)
CR (1) CR20200553A (es)
DK (1) DK3781561T3 (es)
EA (1) EA202092490A1 (es)
FI (1) FI3781561T3 (es)
HR (1) HRP20240793T1 (es)
HU (1) HUE066783T2 (es)
IL (1) IL278013B2 (es)
LT (1) LT3781561T (es)
MA (1) MA52288A (es)
MX (1) MX2020010999A (es)
PE (1) PE20201448A1 (es)
PH (1) PH12020551578A1 (es)
PL (1) PL3781561T3 (es)
PT (1) PT3781561T (es)
RS (1) RS65621B1 (es)
SG (1) SG11202009438UA (es)
SI (1) SI3781561T1 (es)
TW (1) TWI828677B (es)
UA (1) UA127357C2 (es)
WO (1) WO2019204490A1 (es)

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US11919912B2 (en) 2018-05-21 2024-03-05 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
CN114450279B (zh) * 2019-07-24 2024-07-09 星座制药公司 结晶形式
US20220257577A1 (en) 2019-07-24 2022-08-18 Constellation Pharmaceuticals, Inc. Ezh2 inhibition in combination therapies for the treatment of cancers
CN115175905A (zh) * 2020-03-13 2022-10-11 四川海思科制药有限公司 Zeste增强子同源物2抑制剂及其用途
JPWO2022009911A1 (es) * 2020-07-08 2022-01-13
JP2023549564A (ja) * 2020-11-18 2023-11-27 コンステレーション・ファーマシューティカルズ・インコーポレイテッド アンドロゲン受容体変異型前立腺がんの治療のためのｅｚｈ２阻害療法
KR20220101295A (ko) 2021-01-11 2022-07-19 주식회사 엘지에너지솔루션 전극 슬러리의 유량 제어가 가능한 전극 슬러리 코팅 시스템 및 이를 이용한 전극 슬러리 코팅 방법
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