CL2020002698A1 - Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos - Google Patents

Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos

Info

Publication number
CL2020002698A1
CL2020002698A1 CL2020002698A CL2020002698A CL2020002698A1 CL 2020002698 A1 CL2020002698 A1 CL 2020002698A1 CL 2020002698 A CL2020002698 A CL 2020002698A CL 2020002698 A CL2020002698 A CL 2020002698A CL 2020002698 A1 CL2020002698 A1 CL 2020002698A1
Authority
CL
Chile
Prior art keywords
compositions
methyl modifying
modifying enzyme
enzyme modulators
methyl
Prior art date
Application number
CL2020002698A
Other languages
English (en)
Inventor
Alexandre Cöte
Victor S Gehling
Avinash Khanna
Ludivine Moine
Jacob I Stuckey
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of CL2020002698A1 publication Critical patent/CL2020002698A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se proporcionan nuevos compuestos de Fórmula (I): y sales farmacéuticamente aceptables de estos, que son útiles para tratar una variedad de enfermedades, trastornos o afecciones asociadas con enzimas modificadoras de metilo. También se proporcionan composiciones farmacéuticas que comprenden los nuevos compuestos de Fórmula (I), sales farmacéuticamente aceptables de estos y métodos para su uso en el tratamiento de una o más enfermedades, trastornos o afecciones, asociados con enzimas modificadoras de metilo.
CL2020002698A 2018-04-18 2020-10-16 Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos CL2020002698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862659408P 2018-04-18 2018-04-18

Publications (1)

Publication Number Publication Date
CL2020002698A1 true CL2020002698A1 (es) 2021-01-15

Family

ID=66429588

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002698A CL2020002698A1 (es) 2018-04-18 2020-10-16 Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos

Country Status (22)

Country Link
US (3) US10689371B2 (es)
EP (1) EP3781561B1 (es)
JP (2) JP7256823B2 (es)
KR (1) KR20210003160A (es)
CN (1) CN111989325A (es)
AR (1) AR114793A1 (es)
AU (1) AU2019255310B2 (es)
BR (1) BR112020021194A2 (es)
CA (1) CA3098428A1 (es)
CL (1) CL2020002698A1 (es)
CO (1) CO2020014217A2 (es)
CR (1) CR20200553A (es)
EA (1) EA202092490A1 (es)
IL (1) IL278013B2 (es)
MA (1) MA52288A (es)
MX (1) MX2020010999A (es)
PE (1) PE20201448A1 (es)
PH (1) PH12020551578A1 (es)
SG (1) SG11202009438UA (es)
TW (1) TWI828677B (es)
UA (1) UA127357C2 (es)
WO (1) WO2019204490A1 (es)

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CA3100977A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
CN114423426B (zh) * 2019-07-24 2024-04-05 星座制药公司 用于治疗癌症的ezh2抑制联合疗法
CN114450279A (zh) * 2019-07-24 2022-05-06 星座制药公司 7-氯-2-(4-(3-甲氧基氮杂环丁烷-1-基)环己基)-2,4-二甲基-n-((6-甲基-4-(甲硫基)-2-氧代-1,2-二氢吡啶-3-基)甲基)苯并[d][1,3]间二氧杂环戊烯-5-甲酰胺的结晶形式
TW202144341A (zh) * 2020-03-13 2021-12-01 大陸商四川海思科製藥有限公司 Zeste同源基因增強子2抑制劑及其用途
CA3185274A1 (en) * 2020-07-08 2022-01-13 Tsuyoshi Ueda Method for producing 1,3-benzodioxole derivative
IL303025A (en) * 2020-11-18 2023-07-01 Constellation Pharmaceuticals Inc EZH2 inhibition therapies for prostate cancer with androgen receptor mutation
KR20220101295A (ko) 2021-01-11 2022-07-19 주식회사 엘지에너지솔루션 전극 슬러리의 유량 제어가 가능한 전극 슬러리 코팅 시스템 및 이를 이용한 전극 슬러리 코팅 방법
WO2023135564A1 (ko) * 2022-01-14 2023-07-20 동화약품주식회사 1,3-벤조다이옥솔 유도체 화합물 및 이를 포함하는 약학적 조성물
CN116496263A (zh) * 2022-01-27 2023-07-28 江苏天士力帝益药业有限公司 Ezh1/2抑制剂及其制备和抗肿瘤治疗中的应用
WO2023217018A1 (zh) * 2022-05-07 2023-11-16 贝达药业股份有限公司 Ezh2抑制剂及其在医药上的应用
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WO2023244918A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. Quinolone bcl6 bifunctional degraders
WO2024038115A1 (en) 2022-08-17 2024-02-22 Morphosys Ag Therapy comprising anti-cd19 antibody and ezh2 modulators

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