UA95247C2 - Пиримидиновые соединения как модуляторы рецептора серотонина - Google Patents
Пиримидиновые соединения как модуляторы рецептора серотонинаInfo
- Publication number
- UA95247C2 UA95247C2 UAA200801682A UAA200801682A UA95247C2 UA 95247 C2 UA95247 C2 UA 95247C2 UA A200801682 A UAA200801682 A UA A200801682A UA A200801682 A UAA200801682 A UA A200801682A UA 95247 C2 UA95247 C2 UA 95247C2
- Authority
- UA
- Ukraine
- Prior art keywords
- receptor modulators
- serotonin receptor
- pyrimidine compounds
- serotonin
- pyrimidine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
Abstract
В заявке описаны определенные пиримидиновые соединения, которые являются модуляторами рецептора серотонина, пригодные при лечении расстройств, опосредованных серотонином.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70571905P | 2005-08-04 | 2005-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA95247C2 true UA95247C2 (ru) | 2011-07-25 |
Family
ID=37400981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200801682A UA95247C2 (ru) | 2005-08-04 | 2006-07-27 | Пиримидиновые соединения как модуляторы рецептора серотонина |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1928461B1 (ru) |
JP (1) | JP5066088B2 (ru) |
KR (1) | KR101353268B1 (ru) |
CN (1) | CN101277700B (ru) |
AT (1) | ATE539753T1 (ru) |
AU (1) | AU2006278759B2 (ru) |
BR (1) | BRPI0614397A2 (ru) |
CA (1) | CA2617760C (ru) |
CR (1) | CR9791A (ru) |
EA (1) | EA014495B1 (ru) |
HK (1) | HK1118469A1 (ru) |
IL (2) | IL189164A (ru) |
NO (1) | NO340744B1 (ru) |
NZ (1) | NZ565334A (ru) |
UA (1) | UA95247C2 (ru) |
WO (1) | WO2007019083A1 (ru) |
ZA (1) | ZA200802010B (ru) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103788089A (zh) | 2003-09-17 | 2014-05-14 | 詹森药业有限公司 | 作为血清素受体调节剂的稠合杂环化合物 |
US7598255B2 (en) | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
JP2010522156A (ja) * | 2007-03-23 | 2010-07-01 | ファイザー・リミテッド | 5−HT2c作動薬としてのピリミド[4,5−d]アゼピン誘導体 |
JP5562865B2 (ja) | 2007-12-17 | 2014-07-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Trpv1のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター |
KR101770979B1 (ko) * | 2010-05-21 | 2017-08-24 | 애브비 인코포레이티드 | 5ht 수용체의 조절제 및 이의 사용방법 |
RU2636310C1 (ru) | 2014-05-29 | 2017-11-22 | Тайхо Фармасьютикал Ко., Лтд. | Новое тетерагидропиримидиновое соединение или его соль |
CN107365314A (zh) * | 2016-05-11 | 2017-11-21 | 国药集团国瑞药业有限公司 | 一种吡唑类化合物、其晶型及其制备方法 |
CN110177776A (zh) * | 2016-11-15 | 2019-08-27 | 英联邦高等教育系统坦普尔大学 | 5-羟色胺受体7的新型调节剂及其使用方法 |
MA48803A (fr) | 2017-05-31 | 2020-04-08 | Chemocentryx Inc | Cycles 6-5 fusionnés utilisés en tant qu'inhibiteurs de c5a |
KR20200109316A (ko) * | 2017-12-22 | 2020-09-22 | 케모센트릭스, 인크. | C5aR 억제제로서의 디아릴 치환된 6,5-융합 고리 화합물 |
CN111989325A (zh) | 2018-04-18 | 2020-11-24 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
KR102282569B1 (ko) * | 2019-02-08 | 2021-07-29 | (주)퓨쳐켐 | 새로운 18F-표지된 친디엔체와 테트라진 화합물과의 IeDDA 반응을 이용한 18F-표지 방법 |
KR102483492B1 (ko) * | 2019-09-02 | 2023-01-02 | 한양대학교 에리카산학협력단 | 2,5-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물 |
CN114945575A (zh) * | 2019-11-13 | 2022-08-26 | 英联邦高等教育系统坦普尔大学 | 作为5-羟色胺受体7调节剂的新型官能化内酯及其使用方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3969355A (en) * | 1974-11-01 | 1976-07-13 | Morton-Norwich Products, Inc. | 5-Aminoethyl-2,4-diphenylpyrimidine dihydrobromide |
JPH03148265A (ja) * | 1989-11-01 | 1991-06-25 | Sumitomo Chem Co Ltd | 5,7―ジフェニル―4,6―ジアザインダン誘導体、その製造法およびそれを有効成分とする除草剤 |
US5137890A (en) * | 1990-02-14 | 1992-08-11 | Ortho Pharmaceutical Corporation | 4-phenyl tetrahydropyrido(4,3-d)pyrimidines |
PT757685E (pt) * | 1994-04-29 | 2004-10-29 | Pfizer | Novas amidas ciclicas como incrementadores de libertacao de neurotransmissores |
JP3531169B2 (ja) * | 1996-06-11 | 2004-05-24 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
MXPA01009871A (es) * | 1999-04-01 | 2002-04-24 | Pfizer Prod Inc | Aminopiridinas como inhibidores de la sorbitol deshidrogenasa. |
US6806230B1 (en) * | 1999-09-09 | 2004-10-19 | Kumiai Chemical Industry Co., Ltd. | Pyrimidine derivatives and herbicides containing them |
US20040087798A1 (en) * | 2000-03-14 | 2004-05-06 | Akira Yamada | Novel amide compounds |
DE10111842A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Antithrombotische Carbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
CN103788089A (zh) * | 2003-09-17 | 2014-05-14 | 詹森药业有限公司 | 作为血清素受体调节剂的稠合杂环化合物 |
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2006
- 2006-07-27 UA UAA200801682A patent/UA95247C2/ru unknown
- 2006-07-27 KR KR1020087005335A patent/KR101353268B1/ko active IP Right Grant
- 2006-07-27 CN CN2006800364302A patent/CN101277700B/zh not_active Expired - Fee Related
- 2006-07-27 EA EA200800525A patent/EA014495B1/ru unknown
- 2006-07-27 AU AU2006278759A patent/AU2006278759B2/en not_active Ceased
- 2006-07-27 EP EP06788808A patent/EP1928461B1/en active Active
- 2006-07-27 CA CA2617760A patent/CA2617760C/en not_active Expired - Fee Related
- 2006-07-27 NZ NZ565334A patent/NZ565334A/en not_active IP Right Cessation
- 2006-07-27 AT AT06788808T patent/ATE539753T1/de active
- 2006-07-27 JP JP2008525054A patent/JP5066088B2/ja not_active Expired - Fee Related
- 2006-07-27 WO PCT/US2006/029437 patent/WO2007019083A1/en active Application Filing
- 2006-07-27 BR BRPI0614397-0A patent/BRPI0614397A2/pt not_active Application Discontinuation
-
2008
- 2008-01-31 IL IL189164A patent/IL189164A/en active IP Right Grant
- 2008-02-27 NO NO20081034A patent/NO340744B1/no not_active IP Right Cessation
- 2008-03-03 ZA ZA200802010A patent/ZA200802010B/xx unknown
- 2008-03-04 CR CR9791A patent/CR9791A/es not_active Application Discontinuation
- 2008-09-10 HK HK08110066.0A patent/HK1118469A1/xx not_active IP Right Cessation
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2011
- 2011-06-21 IL IL213679A patent/IL213679A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA200800525A1 (ru) | 2008-06-30 |
CA2617760A1 (en) | 2007-02-15 |
IL189164A (en) | 2013-08-29 |
EP1928461B1 (en) | 2012-01-04 |
AU2006278759B2 (en) | 2012-08-16 |
EP1928461A1 (en) | 2008-06-11 |
IL189164A0 (en) | 2008-08-07 |
CN101277700A (zh) | 2008-10-01 |
IL213679A0 (en) | 2011-07-31 |
JP2009503076A (ja) | 2009-01-29 |
EA014495B1 (ru) | 2010-12-30 |
ZA200802010B (en) | 2009-09-30 |
JP5066088B2 (ja) | 2012-11-07 |
KR101353268B1 (ko) | 2014-02-06 |
NZ565334A (en) | 2010-12-24 |
CN101277700B (zh) | 2013-02-20 |
AU2006278759A1 (en) | 2007-02-15 |
ATE539753T1 (de) | 2012-01-15 |
WO2007019083A1 (en) | 2007-02-15 |
BRPI0614397A2 (pt) | 2011-03-29 |
CA2617760C (en) | 2015-02-17 |
HK1118469A1 (en) | 2009-02-13 |
CR9791A (es) | 2010-05-27 |
NO340744B1 (no) | 2017-06-12 |
KR20080033502A (ko) | 2008-04-16 |
NO20081034L (no) | 2008-02-28 |
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