PE20080145A1 - Tetrahidro-pirimidoazepinas como moduladores de trpv1 - Google Patents
Tetrahidro-pirimidoazepinas como moduladores de trpv1Info
- Publication number
- PE20080145A1 PE20080145A1 PE2007000298A PE2007000298A PE20080145A1 PE 20080145 A1 PE20080145 A1 PE 20080145A1 PE 2007000298 A PE2007000298 A PE 2007000298A PE 2007000298 A PE2007000298 A PE 2007000298A PE 20080145 A1 PE20080145 A1 PE 20080145A1
- Authority
- PE
- Peru
- Prior art keywords
- tetrahydro
- phenyl
- alkyl
- pyrimidoazepine
- trpv1
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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Abstract
SE REFIERE A COMPUESTOS TETRAHIDRO-PIRIMIDOAZEPINA DE FORMULA (I), EN DONDE R1 ES H, -NRaRb, ALQUILO(C1-C6), -OALQUILO(C1-C6), -S-ALQUILO(C1-C6), CICLOALQUILO MONOCICLICO, ENTRE OTROS; R2 ES H, ALQUILO(C1-C6); R3 ES FENILO, BENCILO, PIRIDILO, PIRAZINILO, TIOFENILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON Rg; Ar ES FENILO, PIRIDILO, IMIDAZOLILO, PIRIMIDINILO O HETEROARILO FUSIONADO BICICLICO OPCIONALMENTE SUSTITUIDO CON Rk. SON SELECCIONADOS: (4-TER-BUTIL-FENIL)-[7-(3-TRIFLUOROMETIL-PIRIDIN-2-IL)-6,7,8,9-TETRAHIDRO-5H-PIRIMIDO[4,5-d]AZEPIN-4-IL]-AMINA, N-INDAN-2-IL-N,N-DIMETIL-7-(3-TRIFLUORMETIL-PIRIDIN-2-IL)-6,7,8,9-TETRAHIDRO-5H-PIRIMIDO[4,5-d]AZEPIN-2,4-DIAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES DE TRPV1 (PROTEINAS DE CANAL POTENCIAL RECEPTOR TRANSITORIO VAINILLOIDE) Y SON UTILES EN EL TRATAMIENTO DE DOLOR, PRURITO, TOS, ASMA Y ENFERMEDAD INFLAMATORIA DEL INTESTINO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78541506P | 2006-03-21 | 2006-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080145A1 true PE20080145A1 (es) | 2008-02-11 |
Family
ID=38353855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000298A PE20080145A1 (es) | 2006-03-21 | 2007-03-19 | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
Country Status (31)
Country | Link |
---|---|
US (3) | US8673895B2 (es) |
EP (1) | EP2024368B1 (es) |
JP (1) | JP5232768B2 (es) |
KR (1) | KR101461376B1 (es) |
CN (1) | CN101448835B (es) |
AR (1) | AR059985A1 (es) |
AU (1) | AU2007227203B2 (es) |
BR (1) | BRPI0709034B1 (es) |
CA (1) | CA2646977C (es) |
CR (1) | CR10387A (es) |
DK (1) | DK2024368T3 (es) |
EA (1) | EA017069B1 (es) |
EC (1) | ECSP088807A (es) |
ES (1) | ES2474152T3 (es) |
HK (1) | HK1129888A1 (es) |
HR (1) | HRP20140664T1 (es) |
MX (1) | MX2008012163A (es) |
NI (1) | NI200800253A (es) |
NO (1) | NO341676B1 (es) |
NZ (1) | NZ571343A (es) |
PE (1) | PE20080145A1 (es) |
PL (1) | PL2024368T3 (es) |
PT (1) | PT2024368E (es) |
RS (1) | RS53436B (es) |
SG (1) | SG177176A1 (es) |
SI (1) | SI2024368T1 (es) |
TW (1) | TWI440639B (es) |
UA (1) | UA92636C2 (es) |
UY (1) | UY30229A1 (es) |
WO (1) | WO2007109355A2 (es) |
ZA (1) | ZA200808975B (es) |
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WO1998010381A1 (en) * | 1996-09-04 | 1998-03-12 | Intertrust Technologies Corp. | Trusted infrastructure support systems, methods and techniques for secure electronic commerce, electronic transactions, commerce process control and automation, distributed computing, and rights management |
US20080153845A1 (en) * | 2006-10-27 | 2008-06-26 | Redpoint Bio Corporation | Trpv1 antagonists and uses thereof |
AU2008231543B2 (en) * | 2007-03-23 | 2011-07-28 | Pfizer Limited | Pyrimido [4, 5-D] azepine derivatives as 5-HT2C agonists |
WO2009079000A1 (en) * | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolopyrimidine modulators of trpv1 |
WO2009078999A1 (en) | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
TW201018681A (en) * | 2008-07-31 | 2010-05-16 | Genentech Inc | Pyrimidine compounds, compositions and methods of use |
CN102272133A (zh) * | 2008-11-06 | 2011-12-07 | 阿斯利康(瑞典)有限公司 | 淀粉样β的调节剂 |
US20100331305A1 (en) * | 2009-06-24 | 2010-12-30 | Genentech, Inc. | Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use |
US8828990B2 (en) * | 2009-11-12 | 2014-09-09 | Genentech, Inc. | N-7 substituted purine and pyrazolopyrimine compounds, compositions and methods of use |
US8288381B2 (en) * | 2009-11-12 | 2012-10-16 | Genentech, Inc. | N-9 substituted purine compounds, compositions and methods of use |
US10167305B2 (en) | 2010-06-23 | 2019-01-01 | Johnson Matthey Public Limited Company | Allyl complexes for use in coupling reactions |
CN102154494B (zh) * | 2011-03-14 | 2013-01-02 | 中国人民解放军军事医学科学院基础医学研究所 | 一种用于儿童哮喘检测的标志物 |
TWI582073B (zh) | 2013-02-20 | 2017-05-11 | Lg生命科學股份有限公司 | 鞘胺醇-1-磷酸酯受體促效劑、其製造方法及包含該促效劑作爲活性劑之醫藥組成物 |
CN103641762A (zh) * | 2013-12-18 | 2014-03-19 | 中国药科大学 | 一类trpv1/cox-2双重抑制剂、其制备方法及其制备镇痛药物的用途 |
ES2964482T3 (es) | 2019-12-03 | 2024-04-08 | Lg Chem Ltd | Agonista del receptor de esfingosina-1-fosfato, método de preparación del mismo y composición farmacéutica que comprende el mismo como agente activo |
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