PE20070833A1 - Compuestos de pirimidinil benzotiofeno - Google Patents

Compuestos de pirimidinil benzotiofeno

Info

Publication number
PE20070833A1
PE20070833A1 PE2006001456A PE2006001456A PE20070833A1 PE 20070833 A1 PE20070833 A1 PE 20070833A1 PE 2006001456 A PE2006001456 A PE 2006001456A PE 2006001456 A PE2006001456 A PE 2006001456A PE 20070833 A1 PE20070833 A1 PE 20070833A1
Authority
PE
Peru
Prior art keywords
halo
hydroxy
pyrimidinyl
alkyl
compounds
Prior art date
Application number
PE2006001456A
Other languages
English (en)
Inventor
Karl Robert Dahnke
Ho-Shen Lin
Chuan Shih
Q May Wang
Bo Zhang
Michael Enrico Richett
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20070833A1 publication Critical patent/PE20070833A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H, HIDROXI, HALO, METILTIO, ENTRE OTROS; R2 ES H, HIDROXI, HALO, CIANO, ENTRE OTROS; R3 ES H, HALO, METILO; R4 ES -NR6R7, AMINOMETILOCICLOHEXILO, PIPERIDINILO, ENTRE OTROS; R5 ES H CUANDO n ES 1-7, HIDROXI CUANDO n ES 2-7; R6 ES H, ALQUILO C1-C4; R7 ES H, ALQUILO C1-C4, PIPERIDIN-4-ILO, ENTRE OTROS; n ES 1-7. UN COMPUESTO PREFERIDO ES: CICLOPROPILAMIDA DEL ACIDO 2-{5-CLORO-2-[3-(4-METILPIPERAZIN-1-IL)-PROPILAMINO]-PIRIMIDIN-4-IL}BENZO[b]TIOFEN-4-CARBOXILICO. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA IKKBETA Y SON UTILES EN EL TRATAMIENTO DE CANCER Y ENFERMEDADES INFLAMATORIAS
PE2006001456A 2005-11-18 2006-11-15 Compuestos de pirimidinil benzotiofeno PE20070833A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73809705P 2005-11-18 2005-11-18

Publications (1)

Publication Number Publication Date
PE20070833A1 true PE20070833A1 (es) 2007-08-27

Family

ID=38345605

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001456A PE20070833A1 (es) 2005-11-18 2006-11-15 Compuestos de pirimidinil benzotiofeno

Country Status (27)

Country Link
US (1) US7547691B2 (es)
EP (1) EP1989200B1 (es)
JP (1) JP2009516697A (es)
KR (1) KR100990771B1 (es)
CN (1) CN101309918B (es)
AR (1) AR057911A1 (es)
AT (1) ATE437873T1 (es)
AU (1) AU2006337626B2 (es)
BR (1) BRPI0618245A2 (es)
CA (1) CA2629336A1 (es)
CR (1) CR9947A (es)
DE (1) DE602006008187D1 (es)
DK (1) DK1989200T3 (es)
EA (1) EA014426B1 (es)
EC (1) ECSP088456A (es)
ES (1) ES2329085T3 (es)
IL (1) IL190489A0 (es)
MA (1) MA30053B1 (es)
NO (1) NO20082594L (es)
PE (1) PE20070833A1 (es)
PL (1) PL1989200T3 (es)
PT (1) PT1989200E (es)
SI (1) SI1989200T1 (es)
TN (1) TNSN08227A1 (es)
TW (1) TW200800201A (es)
WO (1) WO2007092095A2 (es)
ZA (1) ZA200803940B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117399A2 (en) 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
US20080021217A1 (en) * 2006-07-20 2008-01-24 Allen Borchardt Heterocyclic inhibitors of rho kinase
PL2125794T3 (pl) * 2006-12-21 2011-04-29 Lilly Co Eli Imidazolidynonylo aminopirymidynowe związki do leczenia raka
JP5166441B2 (ja) 2006-12-21 2013-03-21 イーライ リリー アンド カンパニー 癌治療用イミダゾリジノニルアミノピリミジン化合物
WO2008144223A2 (en) 2007-05-16 2008-11-27 Eli Lilly And Company Triazolyl aminopyrimidine compounds
WO2008144222A2 (en) 2007-05-16 2008-11-27 Eli Lilly And Company Triazolyl aminopyrimidine compounds
EP2769721A3 (en) 2008-06-30 2015-04-01 Janssen Pharmaceutica N.V. Process for the preparation of substituted pyrimidine derivatives
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
BR112012003661A2 (pt) 2009-08-19 2017-04-25 Ambit Biosciences Corp "compostos de biarila e métodos de uso dos mesmos."
MX2012012502A (es) 2010-04-27 2013-01-18 Hutchison Medipharma Ltd Compuestos pirimidinil indol.
JP2014512364A (ja) 2011-04-07 2014-05-22 コーネル ユニバーシティー 水溶液中で二量体化できる単量体、およびその使用法
US9245773B2 (en) 2011-09-02 2016-01-26 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device packaging methods and structures thereof
CN103159742B (zh) * 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
AU2013216935C1 (en) * 2012-02-08 2017-12-14 John Emmerson Campbell Heteroaryl compounds and methods of use thereof
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
CN105085434B (zh) * 2014-05-09 2018-02-09 上海特化医药科技有限公司 硫乙拉嗪或其中间体的制备方法
WO2017076888A1 (en) * 2015-11-03 2017-05-11 Janssen Pharmaceutica Nv 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same
EP3490607A4 (en) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
EP3494119A4 (en) 2016-07-29 2020-03-25 Sunovion Pharmaceuticals Inc. CONNECTIONS AND COMPOSITIONS AND USES THEREOF
WO2018140512A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
EP3573971A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
US11358959B2 (en) * 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
CN110831933A (zh) 2017-05-25 2020-02-21 亚瑞克西斯制药公司 喹唑啉衍生物作为突变kras、hras或nras的调节剂
SG10202113146UA (en) 2017-05-25 2021-12-30 Araxes Pharma Llc Covalent inhibitors of kras
EP3661929B1 (en) 2017-08-02 2021-07-14 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
CA3130849A1 (en) 2019-03-14 2020-09-17 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3752589A (en) * 1988-05-16 1989-12-12 Georgia State University Research Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
CA2590939C (en) * 2004-12-17 2011-10-18 Amgen Inc. Aminopyrimidine compounds and methods of use

Also Published As

Publication number Publication date
US7547691B2 (en) 2009-06-16
DE602006008187D1 (de) 2009-09-10
NO20082594L (no) 2008-06-10
IL190489A0 (en) 2008-11-03
JP2009516697A (ja) 2009-04-23
AU2006337626A8 (en) 2008-06-19
CR9947A (es) 2008-11-28
ATE437873T1 (de) 2009-08-15
ES2329085T3 (es) 2009-11-20
SI1989200T1 (sl) 2009-12-31
EP1989200B1 (en) 2009-07-29
KR20080059451A (ko) 2008-06-27
WO2007092095A2 (en) 2007-08-16
US20080306082A1 (en) 2008-12-11
AR057911A1 (es) 2007-12-26
WO2007092095A3 (en) 2007-11-08
TNSN08227A1 (en) 2009-10-30
CN101309918B (zh) 2010-12-29
EP1989200A2 (en) 2008-11-12
CN101309918A (zh) 2008-11-19
PL1989200T3 (pl) 2009-12-31
AU2006337626B2 (en) 2012-03-22
KR100990771B1 (ko) 2010-10-29
ZA200803940B (en) 2009-09-30
EA014426B1 (ru) 2010-12-30
TW200800201A (en) 2008-01-01
BRPI0618245A2 (pt) 2011-08-23
ECSP088456A (es) 2008-06-30
PT1989200E (pt) 2009-10-12
DK1989200T3 (da) 2009-11-09
MA30053B1 (fr) 2008-12-01
EA200801362A1 (ru) 2009-02-27
AU2006337626A1 (en) 2007-08-16
CA2629336A1 (en) 2007-08-16

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