PE20091486A1 - Derivado de pirrolopirimidina como inhibidor de la enzima pi3k - Google Patents
Derivado de pirrolopirimidina como inhibidor de la enzima pi3kInfo
- Publication number
- PE20091486A1 PE20091486A1 PE2009000176A PE2009000176A PE20091486A1 PE 20091486 A1 PE20091486 A1 PE 20091486A1 PE 2009000176 A PE2009000176 A PE 2009000176A PE 2009000176 A PE2009000176 A PE 2009000176A PE 20091486 A1 PE20091486 A1 PE 20091486A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrimidin
- pirrolo
- pi3k
- inhibitor
- morfolin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
REFERIDA A UN DERIVADO DE PIRROLOPIRIMIDINA DE FORMULA (I), DONDE Q ES UN GRUPO LIGADOR -X-Y-; X ES UN ENLACE SIMPLE, CO, CONH, CSNH, ENTRE OTROS; Y ES UN ENLACE SIMPLE, ARILENO, HETEROARILENO, ENTRE OTROS; R1 ES ALQUILENO C0-C6-(A)m-ALQUILO C1-C6 O ALQUILO C0-C6-(A)m-ALQUILENO C0-C6-(HETEROCICLO); A ES CO, CS, CONH, CSNH, ENTRE OTROS; m ES 0 O 1. SON COMPUESTOS PREFERIDOS: 5-{7-[2-(4-ETIL-PIPERAZIN-1-IL)-PIRIDIN-4-IL]-2-MORFOLIN-4-IL-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-PIRIMIDIN-2-ILAMINA, {3-[4-(2-AMINO-PIRIMIDIN-5-IL)-2-MORFOLIN-4-IL-PIRROLO[2,3-d]PIRIMIDIN-7-IL]-4-METIL-FENIL}-MORFOLIN-4-IL-METANONA, 5-(7-METANOSULFONIL-2-MORFOLIN-4-IL-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-PIRIMIDIN-2-ILAMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN METODO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA PI3K Y SON UTILES EN EL TRATAMIENTO DEL CANCER, ENFERMEDADES PROLIFERATIVAS, ENTRE OTRAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008027423 | 2008-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091486A1 true PE20091486A1 (es) | 2009-10-14 |
Family
ID=40952235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000176A PE20091486A1 (es) | 2008-02-07 | 2009-02-05 | Derivado de pirrolopirimidina como inhibidor de la enzima pi3k |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100324284A1 (es) |
EP (1) | EP2239261A4 (es) |
JP (1) | JP5350277B2 (es) |
KR (1) | KR20100120680A (es) |
CN (1) | CN101932584A (es) |
AR (1) | AR070352A1 (es) |
AU (1) | AU2009211622A1 (es) |
BR (1) | BRPI0907931A2 (es) |
CA (1) | CA2711778A1 (es) |
CL (1) | CL2009000241A1 (es) |
IL (1) | IL207452A0 (es) |
MX (1) | MX2010008686A (es) |
PE (1) | PE20091486A1 (es) |
TW (1) | TW200938201A (es) |
WO (1) | WO2009099163A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2209786T3 (da) | 2007-10-05 | 2013-06-03 | Verastem Inc | Pyrimidinsubstituerede purinderivater |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
BRPI0921156A2 (pt) * | 2008-11-11 | 2016-02-23 | Xcovery Holding Co Llc | inibidores de pi3k/mtor quinase |
NZ595372A (en) | 2009-03-27 | 2013-11-29 | Vetdc Inc | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
CN102428085B (zh) | 2009-04-03 | 2015-07-15 | 维拉斯通股份有限公司 | 作为激酶抑制剂的嘧啶取代的嘌呤化合物 |
EP2451802A1 (en) | 2009-07-07 | 2012-05-16 | Pathway Therapeutics, Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
WO2012135160A1 (en) | 2011-03-28 | 2012-10-04 | Pathway Therapeutics Inc. | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
WO2013083810A1 (en) | 2011-12-09 | 2013-06-13 | F. Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
CN103450204B (zh) * | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | 吡咯[2,1-f][1,2,4]并三嗪类化合物,其制备方法及用途 |
MX2015011899A (es) | 2013-03-15 | 2016-05-05 | Genentech Inc | Metodos para el tratamiento de cáncer y prevención de resistencia a los fármacos para el cáncer. |
JP6139789B2 (ja) | 2013-10-16 | 2017-05-31 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合複素環化合物、その調製方法、医薬組成物及びその使用 |
CN111808957A (zh) | 2014-04-04 | 2020-10-23 | 中美冠科生物技术(太仓)有限公司 | 用于确定对mek/erk抑制剂的应答性的方法 |
CN106928232B (zh) * | 2015-12-31 | 2019-07-09 | 上海医药集团股份有限公司 | 喹啉类化合物及其盐的晶型、制备方法、组合物与应用 |
EP3521290A4 (en) * | 2016-09-29 | 2020-04-22 | Daiichi Sankyo Company, Limited | CRYSTALS OF [2- (1-METHYL-1H-PYRAZOL-4-YL) -6- (MORPHOLIN-4-YL) -9H-PURIN-8-YL] [4- (MORPHOLIN-4-YL) PIPERIDIN-1 -YL] METHANONE AND PHARMACEUTICAL SAFE SALT THEREOF |
MX2019013862A (es) | 2017-05-23 | 2020-01-20 | Mei Pharma Inc | Terapia de combinacion. |
MX2020001727A (es) | 2017-08-14 | 2020-03-20 | Mei Pharma Inc | Terapia de combinacion. |
IT201800004082A1 (it) * | 2018-03-29 | 2019-09-29 | Berlin Chemie Ag | Composizioni farmaceutiche antitumorali per terapia combinata |
CN113200969B (zh) * | 2021-05-19 | 2022-11-25 | 中国药科大学 | 一种PI3Kα选择性抑制剂及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU645504B2 (en) | 1989-10-11 | 1994-01-20 | Teijin Limited | Bicyclic pyrimidine derivative, method of producing the same, and pharmaceutical preparation containing the same as active ingredient |
PL175327B1 (pl) * | 1992-04-03 | 1998-12-31 | Upjohn Co | Dwupierścieniowe heterocykliczne aminy |
US5502187A (en) * | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
CN100345830C (zh) * | 2000-04-27 | 2007-10-31 | 安斯泰来制药有限公司 | 稠合杂芳基衍生物 |
GB0100622D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
UY29177A1 (es) * | 2004-10-25 | 2006-05-31 | Astex Therapeutics Ltd | Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos |
KR20090007319A (ko) * | 2006-03-11 | 2009-01-16 | 베르날리스 (알 앤드 디) 리미티드 | Hsp90 억제제로서 사용되는 피롤로피리미딘 유도체 |
AU2007282535B9 (en) * | 2006-08-08 | 2013-06-20 | Chugai Seiyaku Kabushiki Kaisha | Pyrimidine derivative as PI3K inhibitor and use thereof |
-
2009
- 2009-02-04 CL CL2009000241A patent/CL2009000241A1/es unknown
- 2009-02-04 TW TW098103461A patent/TW200938201A/zh unknown
- 2009-02-05 PE PE2009000176A patent/PE20091486A1/es not_active Application Discontinuation
- 2009-02-06 US US12/735,656 patent/US20100324284A1/en not_active Abandoned
- 2009-02-06 JP JP2009552523A patent/JP5350277B2/ja not_active Expired - Fee Related
- 2009-02-06 WO PCT/JP2009/052017 patent/WO2009099163A1/ja active Application Filing
- 2009-02-06 KR KR1020107019767A patent/KR20100120680A/ko not_active Application Discontinuation
- 2009-02-06 AU AU2009211622A patent/AU2009211622A1/en not_active Abandoned
- 2009-02-06 MX MX2010008686A patent/MX2010008686A/es active IP Right Grant
- 2009-02-06 CA CA2711778A patent/CA2711778A1/en not_active Abandoned
- 2009-02-06 BR BRPI0907931-9A patent/BRPI0907931A2/pt not_active IP Right Cessation
- 2009-02-06 EP EP09707958A patent/EP2239261A4/en not_active Withdrawn
- 2009-02-06 AR ARP090100424A patent/AR070352A1/es not_active Application Discontinuation
- 2009-02-06 CN CN2009801039716A patent/CN101932584A/zh active Pending
-
2010
- 2010-08-05 IL IL207452A patent/IL207452A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2239261A1 (en) | 2010-10-13 |
JP5350277B2 (ja) | 2013-11-27 |
TW200938201A (en) | 2009-09-16 |
BRPI0907931A2 (pt) | 2015-07-28 |
CL2009000241A1 (es) | 2010-09-03 |
AU2009211622A1 (en) | 2009-08-13 |
CA2711778A1 (en) | 2009-08-13 |
CN101932584A (zh) | 2010-12-29 |
KR20100120680A (ko) | 2010-11-16 |
US20100324284A1 (en) | 2010-12-23 |
WO2009099163A1 (ja) | 2009-08-13 |
MX2010008686A (es) | 2010-08-30 |
JPWO2009099163A1 (ja) | 2011-05-26 |
AR070352A1 (es) | 2010-03-31 |
EP2239261A4 (en) | 2011-06-08 |
IL207452A0 (en) | 2010-12-30 |
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