ZA200803940B - [4-(Benzo[B]thiophen-2-yl) pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases - Google Patents

[4-(Benzo[B]thiophen-2-yl) pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases

Info

Publication number
ZA200803940B
ZA200803940B ZA200803940A ZA200803940A ZA200803940B ZA 200803940 B ZA200803940 B ZA 200803940B ZA 200803940 A ZA200803940 A ZA 200803940A ZA 200803940 A ZA200803940 A ZA 200803940A ZA 200803940 B ZA200803940 B ZA 200803940B
Authority
ZA
South Africa
Prior art keywords
ikk
thiophen
pyrimidin
benzo
cancer
Prior art date
Application number
ZA200803940A
Other languages
English (en)
Inventor
Dahnke Karl Robert
Shih Chuan
Zhang Bo
Lin Ho-Shen
Wang Q May
Richett Michael Enrico
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA200803940B publication Critical patent/ZA200803940B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200803940A 2005-11-18 2008-05-08 [4-(Benzo[B]thiophen-2-yl) pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases ZA200803940B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73809705P 2005-11-18 2005-11-18

Publications (1)

Publication Number Publication Date
ZA200803940B true ZA200803940B (en) 2009-09-30

Family

ID=38345605

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200803940A ZA200803940B (en) 2005-11-18 2008-05-08 [4-(Benzo[B]thiophen-2-yl) pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases

Country Status (27)

Country Link
US (1) US7547691B2 (xx)
EP (1) EP1989200B1 (xx)
JP (1) JP2009516697A (xx)
KR (1) KR100990771B1 (xx)
CN (1) CN101309918B (xx)
AR (1) AR057911A1 (xx)
AT (1) ATE437873T1 (xx)
AU (1) AU2006337626B2 (xx)
BR (1) BRPI0618245A2 (xx)
CA (1) CA2629336A1 (xx)
CR (1) CR9947A (xx)
DE (1) DE602006008187D1 (xx)
DK (1) DK1989200T3 (xx)
EA (1) EA014426B1 (xx)
EC (1) ECSP088456A (xx)
ES (1) ES2329085T3 (xx)
IL (1) IL190489A0 (xx)
MA (1) MA30053B1 (xx)
NO (1) NO20082594L (xx)
PE (1) PE20070833A1 (xx)
PL (1) PL1989200T3 (xx)
PT (1) PT1989200E (xx)
SI (1) SI1989200T1 (xx)
TN (1) TNSN08227A1 (xx)
TW (1) TW200800201A (xx)
WO (1) WO2007092095A2 (xx)
ZA (1) ZA200803940B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20080130A1 (es) 2006-03-31 2008-02-25 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinas y pirazinas como moduladores del receptor h4 de histamina
CA2658764A1 (en) * 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
EA016177B1 (ru) * 2006-12-21 2012-02-28 Эли Лилли Энд Компани Соединения имидазолидинониламинопиримидина для лечения рака
US8063212B2 (en) * 2006-12-21 2011-11-22 Eli Lilly And Company Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer
PE20090803A1 (es) 2007-05-16 2009-07-11 Lilly Co Eli Compuestos triazolil aminopirimidin como inhibidores de plk1
PE20090216A1 (es) 2007-05-16 2009-02-28 Lilly Co Eli Compuestos triazolil aminopirimidina
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
WO2010002774A1 (en) 2008-06-30 2010-01-07 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
CA2770454A1 (en) 2009-08-19 2011-02-24 Ambit Biosciences Corporation Biaryl compounds and methods of use thereof
BR112012027542A2 (pt) 2010-04-27 2019-09-24 Hutchison Medipharma Ltd compostos de indol de pirimidinil indol
US20140194383A1 (en) 2011-04-07 2014-07-10 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
US9245773B2 (en) 2011-09-02 2016-01-26 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device packaging methods and structures thereof
CN103159742B (zh) * 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
CA2864085C (en) 2012-02-08 2021-11-23 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
CN105085434B (zh) * 2014-05-09 2018-02-09 上海特化医药科技有限公司 硫乙拉嗪或其中间体的制备方法
US9796699B2 (en) 2015-11-03 2017-10-24 Janssen Pharmaceutica Nv Substituted 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same
CN110087687A (zh) 2016-07-29 2019-08-02 赛诺维信制药公司 化合物、组合物及其用途
AU2017301769B2 (en) 2016-07-29 2022-07-28 Pgi Drug Discovery Llc Compounds and compositions and uses thereof
EP3573954A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
EP3573964A1 (en) * 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophene and benzothiazole compounds and methods of use thereof
BR112019024674A2 (pt) 2017-05-25 2020-06-16 Araxes Pharma Llc Inibidores covalentes da kras
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
AU2020236225A1 (en) 2019-03-14 2021-09-16 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3752589A (en) * 1988-05-16 1989-12-12 Georgia State University Research Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
EP1831207B1 (en) * 2004-12-17 2012-11-14 Amgen Inc. Aminopyrimidine compounds as plk inhibitors

Also Published As

Publication number Publication date
BRPI0618245A2 (pt) 2011-08-23
WO2007092095A3 (en) 2007-11-08
DK1989200T3 (da) 2009-11-09
SI1989200T1 (sl) 2009-12-31
AU2006337626A1 (en) 2007-08-16
CA2629336A1 (en) 2007-08-16
CN101309918B (zh) 2010-12-29
KR100990771B1 (ko) 2010-10-29
AR057911A1 (es) 2007-12-26
TW200800201A (en) 2008-01-01
MA30053B1 (fr) 2008-12-01
ECSP088456A (es) 2008-06-30
NO20082594L (no) 2008-06-10
EP1989200B1 (en) 2009-07-29
KR20080059451A (ko) 2008-06-27
DE602006008187D1 (de) 2009-09-10
JP2009516697A (ja) 2009-04-23
AU2006337626A8 (en) 2008-06-19
EA014426B1 (ru) 2010-12-30
PT1989200E (pt) 2009-10-12
PL1989200T3 (pl) 2009-12-31
ATE437873T1 (de) 2009-08-15
EA200801362A1 (ru) 2009-02-27
US20080306082A1 (en) 2008-12-11
CR9947A (es) 2008-11-28
TNSN08227A1 (en) 2009-10-30
WO2007092095A2 (en) 2007-08-16
US7547691B2 (en) 2009-06-16
ES2329085T3 (es) 2009-11-20
PE20070833A1 (es) 2007-08-27
EP1989200A2 (en) 2008-11-12
IL190489A0 (en) 2008-11-03
CN101309918A (zh) 2008-11-19
AU2006337626B2 (en) 2012-03-22

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