HK1143804A1 - 用於治療線粒體疾病的 -醌基 -羥基丁酰胺衍生物 - Google Patents

用於治療線粒體疾病的 -醌基 -羥基丁酰胺衍生物

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Publication number
HK1143804A1
HK1143804A1 HK10110222.7A HK10110222A HK1143804A1 HK 1143804 A1 HK1143804 A1 HK 1143804A1 HK 10110222 A HK10110222 A HK 10110222A HK 1143804 A1 HK1143804 A1 HK 1143804A1
Authority
HK
Hong Kong
Prior art keywords
quinonyl
treatment
mitochondrial diseases
hydroxybutanamide
derivatives
Prior art date
Application number
HK10110222.7A
Other languages
English (en)
Inventor
Orion D Jankowski
Kieron E Wesson
Paul Mollard
William D Shrader
Original Assignee
Edison Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edison Pharmaceuticals Inc filed Critical Edison Pharmaceuticals Inc
Publication of HK1143804A1 publication Critical patent/HK1143804A1/zh

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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