EA201000756A1 - ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ - Google Patents
ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙInfo
- Publication number
- EA201000756A1 EA201000756A1 EA201000756A EA201000756A EA201000756A1 EA 201000756 A1 EA201000756 A1 EA 201000756A1 EA 201000756 A EA201000756 A EA 201000756A EA 201000756 A EA201000756 A EA 201000756A EA 201000756 A1 EA201000756 A1 EA 201000756A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- disclosed
- treatment
- hydroxybutanamide
- derivatives
- Prior art date
Links
- 208000012268 mitochondrial disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024412 Friedreich ataxia Diseases 0.000 abstract 2
- 208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 abstract 2
- 206010048804 Kearns-Sayre syndrome Diseases 0.000 abstract 2
- 201000000639 Leber hereditary optic neuropathy Diseases 0.000 abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 239000000090 biomarker Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 208000032274 Encephalopathy Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 201000002169 Mitochondrial myopathy Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 208000023692 inborn mitochondrial myopathy Diseases 0.000 abstract 1
- 208000006443 lactic acidosis Diseases 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
Classifications
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
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- A61K31/16—Amides, e.g. hydroxamic acids
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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Abstract
Раскрыты способы лечения или подавления митохондриальных заболеваний, таких как атаксия Фридрайха (FRDA), наследственная оптическая нейропатия Лебера (LHON), митохондриальная миопатия, энцефалопатия, лактацидоз и инсульт (MELAS), синдром Кернса-Сэйра (KSS); а также соединения, применимые в способах настоящего изобретения, например, производные 4-(п-хинолил)-2-гидроксибутанамида. Также раскрыты способы и соединения, применимые для лечения других нарушений, например бокового амиотрофического склероза (ALS), болезни Хантингтона, болезни Паркинсона и общего расстройства психологического развития, например аутизма. Также раскрыты энергетические биомаркеры, применимые для оценки метаболического состояния субъекта и эффективности лечения. Также раскрыты способы модулирования, нормализации или усиления энергетических биомаркеров, а также соединения, применимые для этих способов.
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US212607P | 2007-11-06 | 2007-11-06 | |
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PCT/US2008/082374 WO2009061744A2 (en) | 2007-11-06 | 2008-11-04 | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
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EA201791981A EA038941B1 (ru) | 2007-11-06 | 2008-11-04 | ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ |
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Cited By (2)
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RU2770091C2 (ru) * | 2014-12-16 | 2022-04-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Полиморфные и аморфные формы (r)-2-гидрокси-2-метил-4-(2,4,5-триметил-3,6-диоксоциклогекса-1,4-диенил)бутанамида |
RU2793330C2 (ru) * | 2017-11-22 | 2023-03-31 | Кондрион Ип Б.В. | НОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ mPGES-1 |
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