EA201170137A1 - Бензимидазолы и родственные аналоги в качестве модуляторов сиртуина - Google Patents

Бензимидазолы и родственные аналоги в качестве модуляторов сиртуина

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Publication number
EA201170137A1
EA201170137A1 EA201170137A EA201170137A EA201170137A1 EA 201170137 A1 EA201170137 A1 EA 201170137A1 EA 201170137 A EA201170137 A EA 201170137A EA 201170137 A EA201170137 A EA 201170137A EA 201170137 A1 EA201170137 A1 EA 201170137A1
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EA
Eurasian Patent Office
Prior art keywords
sirtuin
disorders
diseases
benzimidazles
related analogues
Prior art date
Application number
EA201170137A
Other languages
English (en)
Other versions
EA020578B1 (ru
Inventor
Чи Б. Ву
Джереми С. Диш
Пуи Йи Нг
Чарльз А. Блум
Роберт Б. Перни
Original Assignee
Сертрис Фармасьютикалз, Инк.
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Publication date
Application filed by Сертрис Фармасьютикалз, Инк. filed Critical Сертрис Фармасьютикалз, Инк.
Publication of EA201170137A1 publication Critical patent/EA201170137A1/ru
Publication of EA020578B1 publication Critical patent/EA020578B1/ru

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

В настоящей заявке представлены сиртуин-модулирующие соединения формулы (II). Сиртуин-модулирующие соединения можно использовать для увеличения продолжительности жизни клетки и для лечения и/или профилактики множества различных заболеваний и расстройств, включая, например, заболевания или расстройства, связанные со старением или стрессом, диабет, ожирение, нейродегенеративные заболевания, сердечно-сосудистое заболевание, нарушения свертываемости крови, воспаление, рак и/или приливы, а также заболевания или расстройства, для которых будет полезным повышение митохондриальной активности. Также представлены композиции, включающие сиртуин-модулирующее соединение в сочетании с другим терапевтическим средством.
EA201170137A 2008-07-03 2009-07-02 Бензимидазолы и родственные аналоги в качестве модуляторов сиртуина EA020578B1 (ru)

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IL210206A (en) 2016-06-30
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CN104193740A (zh) 2014-12-10
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JP2015051987A (ja) 2015-03-19
CA2729128C (en) 2016-05-31
KR20110036602A (ko) 2011-04-07
CN102143957A (zh) 2011-08-03
US20150057272A1 (en) 2015-02-26
CA2729128A1 (en) 2010-01-07
EP2315763B1 (en) 2016-06-01
EA020578B1 (ru) 2014-12-30
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BRPI0914006A2 (pt) 2015-10-27
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