EA201171098A1 - 8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина - Google Patents

8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина

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Publication number
EA201171098A1
EA201171098A1 EA201171098A EA201171098A EA201171098A1 EA 201171098 A1 EA201171098 A1 EA 201171098A1 EA 201171098 A EA201171098 A EA 201171098A EA 201171098 A EA201171098 A EA 201171098A EA 201171098 A1 EA201171098 A1 EA 201171098A1
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Eurasian Patent Office
Prior art keywords
diseases
disorders
quinolines
substitute
sirtuinmodulating
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Application number
EA201171098A
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English (en)
Inventor
Чи Б. Ву
Ребекка Л. Касаубон
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Сертрис Фармасьютикалз, Инк.
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Publication of EA201171098A1 publication Critical patent/EA201171098A1/ru

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A—HUMAN NECESSITIES
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Изобретение относится к 8-замещенным хинолинам и родственным аналогам в качестве сиртуинмодулирующих соединений структурной формулы (I) и способам их применения. Сиртуинмодулирующие соединения можно применять для увеличения продолжительности жизни клетки и лечения и/или предотвращения широкого спектра заболеваний и расстройств, включая, например, заболевания или расстройства, связанные со старением или стрессом, диабет, ожирение, нейродегенеративные заболевания, сердечно-сосудистое заболевание, коагулопатию, воспаление, рак и/или гиперемию, а также заболевания или расстройства, при которых будет полезна повышенная митохондриальная активность. Также настоящее изобретение относится к композициям, содержащим сиртуинмодулирующее соединение в комбинации с другим терапевтическим агентом.
EA201171098A 2009-03-02 2010-03-02 8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина EA201171098A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15674909P 2009-03-02 2009-03-02
PCT/US2010/025963 WO2010101949A1 (en) 2009-03-02 2010-03-02 8-substituted quinolines and related analogs as sirtuin modulators

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EA201171098A1 true EA201171098A1 (ru) 2012-04-30

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EP (1) EP2403833A4 (ru)
JP (1) JP2012519211A (ru)
KR (1) KR20110128908A (ru)
CN (1) CN102414180A (ru)
AU (1) AU2010221417A1 (ru)
BR (1) BRPI1011477A2 (ru)
CA (1) CA2754058A1 (ru)
EA (1) EA201171098A1 (ru)
IL (1) IL214943A0 (ru)
MX (1) MX2011009213A (ru)
WO (1) WO2010101949A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2669943C2 (ru) * 2013-07-29 2018-10-17 Ф. Хоффманн-Ля Рош Аг Производные 1,7-нафтиридин-3-карбоксамида, полезные в качестве нейрогенных агентов

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685970B2 (en) 2008-05-01 2014-04-01 GlaxoSmithKline, LLC Quinolines and related analogs as sirtuin modulators
WO2010003048A1 (en) 2008-07-03 2010-01-07 Sirtris Pharmaceuticals, Inc. Benzimidazoles and related analogs as sirtuin modulators
WO2010037127A1 (en) 2008-09-29 2010-04-01 Sirtris Pharmaceuticals, Inc. Chromenone analogs as sirtuin modulators
CA2779303A1 (en) 2009-10-29 2011-05-19 Sirtris Pharmaceuticals, Inc. Bicyclic pyridines and analogs as sirtuin modulators
EP2571357B1 (en) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
DK2686303T3 (en) 2011-03-18 2016-03-29 Bayer Ip Gmbh N- (3-carbamoylphenyl) -1 H -pyrazole-5-carboxamide derivatives and their use for controlling animal pests
CN102250151B (zh) * 2011-05-17 2013-11-06 中国科学院化学研究所 2-芳亚胺-8-苯并咪唑喹啉过渡金属配合物及其制备方法与应用
SG11201400310WA (en) 2011-08-29 2014-06-27 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
CA2852936A1 (en) 2011-10-20 2013-04-25 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
KR20140077964A (ko) * 2011-10-20 2014-06-24 글락소스미스클라인 엘엘씨 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체
CA2865043A1 (en) 2012-03-13 2013-09-19 Basf Se Fungicidal pyrimidine compounds
KR20150085538A (ko) 2012-11-20 2015-07-23 에프. 호프만-라 로슈 아게 치환된 1,6-나프티리딘
DK2970272T3 (en) * 2013-03-14 2019-04-23 Merck Patent Gmbh glycosidase
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2014195333A1 (de) 2013-06-04 2014-12-11 Bayer Pharma Aktiengesellschaft 3-aryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
US20160221964A1 (en) 2013-09-16 2016-08-04 Basf Se Fungicidal pyrimidine compounds
US10172915B2 (en) 2013-10-20 2019-01-08 Duke University Methods and compositions for activation of sirtuins with Annexin A1 peptides
JP6112724B2 (ja) * 2013-10-31 2017-04-12 日本化薬株式会社 １，５−ナフチリジン誘導体およびそれを有効成分として含んでなる殺虫剤
CN105764901B (zh) 2013-11-12 2018-06-22 豪夫迈·罗氏有限公司 作为用于治疗神经变性疾病的神经源性药的吡啶并[4，3-b]吡嗪-2-甲酰胺
WO2015107133A1 (de) 2014-01-20 2015-07-23 Bayer Cropscience Ag Chinolinderivate als insektizide und akarizide
CA2939793A1 (en) 2014-02-19 2015-08-27 Bayer Pharma Aktiengesellschaft 3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines
JP6580074B2 (ja) 2014-05-23 2019-09-25 アクティブ バイオテック エイビー Ｓ１００阻害薬として有用な新規化合物
CN106817900A (zh) * 2014-07-17 2017-06-09 默克专利有限公司 新颖的萘啶和异喹啉及其作为cdk8/19抑制剂的用途
AU2015295405B2 (en) 2014-08-01 2020-04-09 Nuevolution A/S Compounds active towards bromodomains
MA40532A (fr) 2014-08-28 2021-04-28 Asceneuron Sa Inhibiteurs de glycosidases
CN107001361A (zh) 2014-12-02 2017-08-01 拜耳医药股份有限公司 杂芳基取代的咪唑并[1，2‑a]吡啶及其用途
CN104592109A (zh) * 2015-01-19 2015-05-06 湖南华腾制药有限公司 一种8-溴喹啉衍生物的制备方法
BR112017017032A2 (pt) * 2015-02-11 2018-04-10 Basilea Pharmaceutica International AG derivados de mono e poliazanaftaleno substituídos e uso dos mesmos
SG11201807012QA (en) 2016-02-25 2018-09-27 Asceneuron S A Acid addition salts of piperazine derivatives
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
AU2017222964B2 (en) 2016-02-25 2020-01-02 Asceneuron S. A. Glycosidase inhibitors
EP3419971B1 (en) 2016-02-25 2022-04-20 Asceneuron SA Glycosidase inhibitors
WO2019037860A1 (en) 2017-08-24 2019-02-28 Asceneuron S.A. LINEAR INHIBITORS OF GLYCOSIDASE
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors
WO2020039028A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Tetrahydro-benzoazepine glycosidase inhibitors
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
BR112021017049A2 (pt) * 2019-02-28 2022-02-08 Kezar Life Sciences Derivados de tiazol como inibidores de secreção de proteínas
CN110964011B (zh) * 2019-12-16 2022-06-21 诚达药业股份有限公司 一种8-氯-1,7-萘啶-3-甲醛的合成方法
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
CR20230057A (es) 2020-07-02 2023-08-15 Incyte Corp Compuestos tríciclicos de urea como inhibidores de jak2 v617f
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
CA3211748A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
WO2024059216A2 (en) * 2022-09-15 2024-03-21 Vanderbilt University 6,6 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same
WO2024059212A2 (en) * 2022-09-15 2024-03-21 Vanderbilt University 6,6 western core compounds as mglu5 negative allosteric modulators and methods of making and using the same
CN117362286B (zh) * 2023-12-08 2024-03-12 清华大学 具有sirt6激动活性的化合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029318A1 (en) * 1997-12-11 1999-06-17 Biochem Pharma Inc. Antiviral compounds
FR2827599A1 (fr) * 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
SE0103649D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinoline compounds
EP1601357A4 (en) * 2003-03-10 2007-10-03 Schering Corp HETEROCYCLIC KINASE INHIBITORS: METHOD OF USE AND SYNTHESIS
EP1773834A2 (en) * 2004-08-03 2007-04-18 Serenex, Inc. 2, 8-disubstituted naphthyridine derivatives
WO2006094237A2 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Acridine and quinoline dervatives as sirtuin modulators
EP2250152A1 (en) * 2008-02-28 2010-11-17 Novartis AG Quinolines as inhibitors of farnesyl pyrophosphate synthase
US8685970B2 (en) * 2008-05-01 2014-04-01 GlaxoSmithKline, LLC Quinolines and related analogs as sirtuin modulators
WO2010037127A1 (en) * 2008-09-29 2010-04-01 Sirtris Pharmaceuticals, Inc. Chromenone analogs as sirtuin modulators

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2669943C2 (ru) * 2013-07-29 2018-10-17 Ф. Хоффманн-Ля Рош Аг Производные 1,7-нафтиридин-3-карбоксамида, полезные в качестве нейрогенных агентов

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EP2403833A4 (en) 2012-08-29
BRPI1011477A2 (pt) 2016-03-22
WO2010101949A1 (en) 2010-09-10
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