EA201171098A1 - 8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина - Google Patents

8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина

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EA201171098A1
EA201171098A1 EA201171098A EA201171098A EA201171098A1 EA 201171098 A1 EA201171098 A1 EA 201171098A1 EA 201171098 A EA201171098 A EA 201171098A EA 201171098 A EA201171098 A EA 201171098A EA 201171098 A1 EA201171098 A1 EA 201171098A1
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Prior art keywords
diseases
disorders
quinolines
substitute
sirtuinmodulating
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EA201171098A
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English (en)
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Чи Б. Ву
Ребекка Л. Касаубон
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Сертрис Фармасьютикалз, Инк.
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Publication of EA201171098A1 publication Critical patent/EA201171098A1/ru

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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/47Quinolines; Isoquinolines
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    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Quinoline Compounds (AREA)
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Abstract

Изобретение относится к 8-замещенным хинолинам и родственным аналогам в качестве сиртуинмодулирующих соединений структурной формулы (I) и способам их применения. Сиртуинмодулирующие соединения можно применять для увеличения продолжительности жизни клетки и лечения и/или предотвращения широкого спектра заболеваний и расстройств, включая, например, заболевания или расстройства, связанные со старением или стрессом, диабет, ожирение, нейродегенеративные заболевания, сердечно-сосудистое заболевание, коагулопатию, воспаление, рак и/или гиперемию, а также заболевания или расстройства, при которых будет полезна повышенная митохондриальная активность. Также настоящее изобретение относится к композициям, содержащим сиртуинмодулирующее соединение в комбинации с другим терапевтическим агентом.
EA201171098A 2009-03-02 2010-03-02 8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина EA201171098A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15674909P 2009-03-02 2009-03-02
PCT/US2010/025963 WO2010101949A1 (en) 2009-03-02 2010-03-02 8-substituted quinolines and related analogs as sirtuin modulators

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EA201171098A1 true EA201171098A1 (ru) 2012-04-30

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EP (1) EP2403833A4 (ru)
JP (1) JP2012519211A (ru)
KR (1) KR20110128908A (ru)
CN (1) CN102414180A (ru)
AU (1) AU2010221417A1 (ru)
BR (1) BRPI1011477A2 (ru)
CA (1) CA2754058A1 (ru)
EA (1) EA201171098A1 (ru)
IL (1) IL214943A0 (ru)
MX (1) MX2011009213A (ru)
WO (1) WO2010101949A1 (ru)

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EP2403833A4 (en) 2012-08-29
BRPI1011477A2 (pt) 2016-03-22
WO2010101949A1 (en) 2010-09-10
CN102414180A (zh) 2012-04-11
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CA2754058A1 (en) 2010-09-10
AU2010221417A1 (en) 2011-09-22

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